Abstract:
Interleukin (IL)-23 is a member of the IL-12 family of cytokines that, as the other members of this family, is secreted by monocytes, macrophages, and dendritic cells (DC) upon recognition of bacterial, viral, and fungal components. IL-23 is critical during immunity against acute infections, and it is also involved in the development of autoimmune diseases. Although immunoregulatory effects of IL-23 on mouse natural killer (NK) cells have been described, the effect of IL-23 on human NK cells remains ill-defined. In this study, we observed that monocytes stimulated with LPS secreted IL-23 and that blockade of this cytokine during monocyte and NK cell coculture led to a diminished production of IFN-γ by NK cells. Accordingly, rIL-23-induced NK cell activation and stimulated IFN-γ production by CD56bright NK cells. This effect involved MEK1/MEK2, JNK, PI3K, mammalian target of rapamycin, and NF-κB, but not STAT-1, STAT-3, nor p38 MAPK pathways. Moreover, while NK cell-mediated cytotoxicity remained unaltered, antibody-dependent cellular cytotoxicity (ADCC) was enhanced after IL-23 stimulation. In addition, IL-23 displayed a synergistic effect with IL-18 for IFN-γ production by both CD56bright and CD56dim NK cells, and this effect was due to a priming effect of IL-23 for IL-18 responsiveness. Furthermore, NK cells pre-stimulated with IL-18 promoted an increase in CD86 expression and IL-12 secretion by DC treated with LPS, and IL-23 potentiated these effects. Moreover, IL-23-driven enhancement of NK cell "helper" function was dependent on NK cell-derived IFN-γ. Therefore, our results suggest that IL-23 may trigger NK cell-mediated "helper" effects on adaptive immunity, shaping T cell responses during different pathological situations through the regulation of DC maturation. © 2018 Ziblat, Nuñez, Raffo Iraolagoitia, Spallanzani, Torres, Sierra, Secchiari, Domaica, Fuertes and Zwirner.
Registro:
Documento: |
Artículo
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Título: | Interleukin (IL)-23 stimulates IFN-γ secretion by CD56bright natural killer cells and enhances IL-18-driven dendritic cells activation |
Autor: | Ziblat, A.; Nuñez, S.Y.; Iraolagoitia, X.L.R.; Spallanzani, R.G.; Torres, N.I.; Sierra, J.M.; Secchiari, F.; Domaica, C.I.; Fuertes, M.B.; Zwirner, N.W. |
Filiación: | Instituto de Biología y Medicina Experimental (IBYME-CONICET), Laboratorio de Fisiopatología de la Inmunidad Innata, Buenos Aires, Argentina Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina Cancer Research UK Beatson Institute, Bearsden, Glasgow, United Kingdom Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, United States
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Palabras clave: | Dendritic cells; IFN-γ; Interleukin-18; Interleukin-23; Natural killer cells; CD56 antigen; gamma interferon; interleukin 18; interleukin 23; mitogen activated protein kinase kinase 1; mitogen activated protein kinase kinase 2; stress activated protein kinase; adaptive immunity; antibody dependent cellular cytotoxicity; Article; cell activation; cell death; cell proliferation; cell selection; controlled study; cytokine release; dendritic cell; enzyme linked immunosorbent assay; flow cytometry; human; human cell; monocyte; natural killer cell; natural killer cell mediated cytotoxicity; normal human; protein expression |
Año: | 2018
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Volumen: | 8
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Número: | JAN
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DOI: |
http://dx.doi.org/10.3389/fimmu.2017.01959 |
Título revista: | Frontiers in Immunology
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Título revista abreviado: | Front. Immunol.
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ISSN: | 16643224
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CAS: | gamma interferon, 82115-62-6; interleukin 18, 189304-55-0; stress activated protein kinase, 155215-87-5
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16643224_v8_nJAN_p_Ziblat |
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Citas:
---------- APA ----------
Ziblat, A., Nuñez, S.Y., Iraolagoitia, X.L.R., Spallanzani, R.G., Torres, N.I., Sierra, J.M., Secchiari, F.,..., Zwirner, N.W.
(2018)
. Interleukin (IL)-23 stimulates IFN-γ secretion by CD56bright natural killer cells and enhances IL-18-driven dendritic cells activation. Frontiers in Immunology, 8(JAN).
http://dx.doi.org/10.3389/fimmu.2017.01959---------- CHICAGO ----------
Ziblat, A., Nuñez, S.Y., Iraolagoitia, X.L.R., Spallanzani, R.G., Torres, N.I., Sierra, J.M., et al.
"Interleukin (IL)-23 stimulates IFN-γ secretion by CD56bright natural killer cells and enhances IL-18-driven dendritic cells activation"
. Frontiers in Immunology 8, no. JAN
(2018).
http://dx.doi.org/10.3389/fimmu.2017.01959---------- MLA ----------
Ziblat, A., Nuñez, S.Y., Iraolagoitia, X.L.R., Spallanzani, R.G., Torres, N.I., Sierra, J.M., et al.
"Interleukin (IL)-23 stimulates IFN-γ secretion by CD56bright natural killer cells and enhances IL-18-driven dendritic cells activation"
. Frontiers in Immunology, vol. 8, no. JAN, 2018.
http://dx.doi.org/10.3389/fimmu.2017.01959---------- VANCOUVER ----------
Ziblat, A., Nuñez, S.Y., Iraolagoitia, X.L.R., Spallanzani, R.G., Torres, N.I., Sierra, J.M., et al. Interleukin (IL)-23 stimulates IFN-γ secretion by CD56bright natural killer cells and enhances IL-18-driven dendritic cells activation. Front. Immunol. 2018;8(JAN).
http://dx.doi.org/10.3389/fimmu.2017.01959