Abstract:
Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune response and have been used since decades to treat various inflammatory and autoimmune disorders. Fine-tuning the glucocorticoid receptor (GR) activity is instrumental in the search for novel therapeutic strategies aimed to reduce pathological signaling and restoring homeostasis. Despite the primary anti-inflammatory actions of GCs, there are studies suggesting that under certain conditions GCs may also exert pro-inflammatory responses. For these reasons the understanding of the GR basic mechanisms of action on different immune cells in the periphery (e.g., macrophages, dendritic cells, neutrophils, and T cells) and in the brain (microglia) contexts, that we review in this chapter, is a continuous matter of interest and may reveal novel therapeutic targets for the treatment of immune and inflammatory response. © 2018 Liberman, Budziñski, Sokn, Gobbini, Steininger and Arzt.
Registro:
Documento: |
Artículo
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Título: | Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells |
Autor: | Liberman, A.C.; Budziñski, M.L.; Sokn, C.; Gobbini, R.P.; Steininger, A.; Arzt, E. |
Filiación: | Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET, Partner Institute of the Max Planck Society, Buenos Aires, Argentina Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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Palabras clave: | FKBP51; Glucocorticoids; Inflammation; Transactivation; Transrepression; glucocorticoid; glucocorticoid receptor; heat shock protein 90; histone acetyltransferase; interleukin 12; interleukin 6; lipocortin 1; matrix metalloproteinase; phospholipase A2; tumor necrosis factor; alternative RNA splicing; chronic stress; DNA binding; gene expression; immune response; inflammatory cell; nerve cell degeneration; phagocytosis; protein processing; Review; sensitivity and specificity; sumoylation; T lymphocyte; transactivation |
Año: | 2018
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Volumen: | 9
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Número: | MAY
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DOI: |
http://dx.doi.org/10.3389/fendo.2018.00235 |
Título revista: | Frontiers in Endocrinology
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Título revista abreviado: | Front. Endocrinol.
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ISSN: | 16642392
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CAS: | histone acetyltransferase, 9054-51-7; histone acetyltransferase KAT5; interleukin 12, 138415-13-1; phospholipase A2, 9001-84-7
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16642392_v9_nMAY_p_Liberman |
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Citas:
---------- APA ----------
Liberman, A.C., Budziñski, M.L., Sokn, C., Gobbini, R.P., Steininger, A. & Arzt, E.
(2018)
. Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells. Frontiers in Endocrinology, 9(MAY).
http://dx.doi.org/10.3389/fendo.2018.00235---------- CHICAGO ----------
Liberman, A.C., Budziñski, M.L., Sokn, C., Gobbini, R.P., Steininger, A., Arzt, E.
"Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells"
. Frontiers in Endocrinology 9, no. MAY
(2018).
http://dx.doi.org/10.3389/fendo.2018.00235---------- MLA ----------
Liberman, A.C., Budziñski, M.L., Sokn, C., Gobbini, R.P., Steininger, A., Arzt, E.
"Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells"
. Frontiers in Endocrinology, vol. 9, no. MAY, 2018.
http://dx.doi.org/10.3389/fendo.2018.00235---------- VANCOUVER ----------
Liberman, A.C., Budziñski, M.L., Sokn, C., Gobbini, R.P., Steininger, A., Arzt, E. Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells. Front. Endocrinol. 2018;9(MAY).
http://dx.doi.org/10.3389/fendo.2018.00235