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Urbano, F.J.; Kezunovic, N.; Hyde, J.; Simon, C.; Beck, P.; Garcia-Rill, E. "Gamma band activity in the reticular activating system" (2012) Frontiers in Neurology. JAN
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Abstract:

This review considers recent evidence showing that cells in three regions of the reticu-lar activating system (RAS) exhibit gamma b activity, describes the mechanisms behind such manifestation. Specifically, we discuss how cells in the mesopontine peduncu-lopontine nucleus (PPN), intralaminar parafascicular nucleus (Pf), pontine subcoeruleus nucleus dorsalis (SubCD) all fire in the beta/gamma b range when maximally activated, but no higher.The mechanisms behind this ceiling effect have been recently elucidated.We describe recent findings showing that every cell in the PPN have high-threshold, voltage-dependent P/Q-type calcium channels that are essential, while N-type calcium channels are permissive, to gamma b activity. Every cell in the Pf also showed that P/Q-type N-type calcium channels are responsible for this activity. On the other h, every SubCD cell exhibited sodium-dependent subthreshold oscillations. A novel mechanism for sleep-wake control based on well-known transmitter interactions, electrical coupling, gamma b activity is described. The data presented here on inherent gamma b activity demonstrates the global nature of sleep-wake oscillation that is orchestrated by brainstem-thalamic mechanism, questions the undue importance given to the hypo-thalamus for regulation of sleep-wakefulness.The discovery of gamma b activity in the RAS follows recent reports of such activity in other subcortical regions like the hippocam-pus cerebellum. We hypothesize that, rather than participating in the temporal binding of sensory events as seen in the cortex, gamma b activity manifested in the RAS may help stabilize coherence related to arousal, providing a stable activation state during wak-ing paradoxical sleep. Most of our thoughts actions are driven by pre-conscious processes. We speculate that continuous sensory input will induce gamma b activity in the RAS that could participate in the processes of pre-conscious awareness, provide the essential stream of information for the formulation of many of our actions.Copyright © 2012 Urbano, Kezunovic, Hyde, Simon, Beck Garcia-Rill.

Registro:

Documento: Artículo
Título:Gamma band activity in the reticular activating system
Autor:Urbano, F.J.; Kezunovic, N.; Hyde, J.; Simon, C.; Beck, P.; Garcia-Rill, E.
Filiación:Instituto de Fisiología, Biología Molecular y Neurociencias, Consejo Nacional de Investigaciones Científicas y Técnicas, University of Buenos Aires, Buenos Aires, Argentina
Department of Neurobiology Developmental Sciences, Center forTranslational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, United States
Palabras clave:Arousal; Calcium channels; Gamma b; Subthreshold oscillations
Año:2012
Volumen:JAN
DOI: http://dx.doi.org/10.3389/fneur.2012.00006
Título revista:Frontiers in Neurology
Título revista abreviado:Front. Neurol.
ISSN:16642295
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16642295_vJAN_n_p_Urbano

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Citas:

---------- APA ----------
Urbano, F.J., Kezunovic, N., Hyde, J., Simon, C., Beck, P. & Garcia-Rill, E. (2012) . Gamma band activity in the reticular activating system. Frontiers in Neurology, JAN.
http://dx.doi.org/10.3389/fneur.2012.00006
---------- CHICAGO ----------
Urbano, F.J., Kezunovic, N., Hyde, J., Simon, C., Beck, P., Garcia-Rill, E. "Gamma band activity in the reticular activating system" . Frontiers in Neurology JAN (2012).
http://dx.doi.org/10.3389/fneur.2012.00006
---------- MLA ----------
Urbano, F.J., Kezunovic, N., Hyde, J., Simon, C., Beck, P., Garcia-Rill, E. "Gamma band activity in the reticular activating system" . Frontiers in Neurology, vol. JAN, 2012.
http://dx.doi.org/10.3389/fneur.2012.00006
---------- VANCOUVER ----------
Urbano, F.J., Kezunovic, N., Hyde, J., Simon, C., Beck, P., Garcia-Rill, E. Gamma band activity in the reticular activating system. Front. Neurol. 2012;JAN.
http://dx.doi.org/10.3389/fneur.2012.00006