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Abstract:

Functional magnetic resonance imaging (fMRI) techniques have contributed significantly to our understanding of brain function. Current methods are based on the analysis of gradual and continuous changes in the brain blood oxygenated level dependent (BOLD) signal. Departing from that approach, recent work has shown that equivalent results can be obtained by inspecting only the relatively large amplitude BOLD signal peaks, suggesting that relevant information can be condensed in discrete events. This idea is further explored here to demonstrate how brain dynamics at resting state can be captured just by the timing and location of such events, i.e., in terms of a spatiotemporal point process. The method allows, for the first time, to define a theoretical framework in terms of an order and control parameter derived from fMRI data, where the dynamical regime can be interpreted as one corresponding to a system close to the critical point of a second order phase transition. The analysis demonstrates that the resting brain spends most of the time near the critical point of such transition and exhibits avalanches of activity ruled by the same dynamical and statistical properties described previously for neuronal events at smaller scales. Given the demonstrated functional relevance of the resting state brain dynamics, its representation as a discrete process might facilitate large-scale analysis of brain function both in health and disease. © 2012 Tagliazucchi, Balen-zuela, Fraiman and Chialvo.

Registro:

Documento: Artículo
Título:Criticality in large-scale brain fmri dynamics unveiled by a novel point process analysis
Autor:Tagliazucchi, E.; Balenzuela, P.; Fraiman, D.; Chialvo, D.R.
Filiación:Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Department of Neurology and Brain Imaging Center, Goethe-University Frankfurt, Frankfurt am Main, Germany
Consejo Nacional de Investigaciones Científicas yTecnológicas, Buenos Aires, Argentina
Departamento de Matemática y Ciencias, Universidad de San Andrés, Buenos Aires, Argentina
Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States
Palabras clave:Brain dynamics; Criticality; Fmri; Point processes
Año:2012
Volumen:3 FEB
DOI: http://dx.doi.org/10.3389/fphys.2012.00015
Título revista:Frontiers in Physiology
Título revista abreviado:Front. Physiol.
ISSN:1664042X
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1664042X_v3FEB_n_p_Tagliazucchi

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Citas:

---------- APA ----------
Tagliazucchi, E., Balenzuela, P., Fraiman, D. & Chialvo, D.R. (2012) . Criticality in large-scale brain fmri dynamics unveiled by a novel point process analysis. Frontiers in Physiology, 3 FEB.
http://dx.doi.org/10.3389/fphys.2012.00015
---------- CHICAGO ----------
Tagliazucchi, E., Balenzuela, P., Fraiman, D., Chialvo, D.R. "Criticality in large-scale brain fmri dynamics unveiled by a novel point process analysis" . Frontiers in Physiology 3 FEB (2012).
http://dx.doi.org/10.3389/fphys.2012.00015
---------- MLA ----------
Tagliazucchi, E., Balenzuela, P., Fraiman, D., Chialvo, D.R. "Criticality in large-scale brain fmri dynamics unveiled by a novel point process analysis" . Frontiers in Physiology, vol. 3 FEB, 2012.
http://dx.doi.org/10.3389/fphys.2012.00015
---------- VANCOUVER ----------
Tagliazucchi, E., Balenzuela, P., Fraiman, D., Chialvo, D.R. Criticality in large-scale brain fmri dynamics unveiled by a novel point process analysis. Front. Physiol. 2012;3 FEB.
http://dx.doi.org/10.3389/fphys.2012.00015