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Abstract:

Mean field models are often useful approximations to biological systems, but sometimes, they can yield misleading results. In this work, we compare mean field approaches with stochastic models of intracellular calcium release. In particular, we concentrate on calcium signals generated by the concerted opening of several clustered channels (calcium puffs). To this end we simulate calcium puffs numerically and then try to reproduce features of the resulting calcium distribution using mean field models were all the channels open and close simultaneously. We show that an unrealistic non-linear relationship between the current and the number of open channels is needed to reproduce the simulated puffs. Furthermore, a single channel current which is five times smaller than the one of the stochastic simulations is also needed. Our study sheds light on the importance of the stochastic kinetics of the calcium release channel activity to estimate the release fluxes. © 2011 Solovey, Fraiman and Dawson.

Registro:

Documento: Artículo
Título:Mean field strategies induce unrealistic non-linearities in calcium puffs
Autor:Solovey, G.; Fraiman, D.; Dawson, S.P.
Filiación:Laboratory of Mathematical Physics, The Rockefeller University, New York, NY, United States
Departamento de Matematica y Ciencias, Universidad de San Andres, Buenos Aires, Argentina
Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
Palabras clave:Calcium signals; Mean field model; Puffs; Stochastic model
Año:2011
Volumen:2 AUG
DOI: http://dx.doi.org/10.3389/fphys.2011.00046
Título revista:Frontiers in Physiology
Título revista abreviado:Front. Physiol.
ISSN:1664042X
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_1664042X_v2AUG_n_p_Solovey.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1664042X_v2AUG_n_p_Solovey

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Citas:

---------- APA ----------
Solovey, G., Fraiman, D. & Dawson, S.P. (2011) . Mean field strategies induce unrealistic non-linearities in calcium puffs. Frontiers in Physiology, 2 AUG.
http://dx.doi.org/10.3389/fphys.2011.00046
---------- CHICAGO ----------
Solovey, G., Fraiman, D., Dawson, S.P. "Mean field strategies induce unrealistic non-linearities in calcium puffs" . Frontiers in Physiology 2 AUG (2011).
http://dx.doi.org/10.3389/fphys.2011.00046
---------- MLA ----------
Solovey, G., Fraiman, D., Dawson, S.P. "Mean field strategies induce unrealistic non-linearities in calcium puffs" . Frontiers in Physiology, vol. 2 AUG, 2011.
http://dx.doi.org/10.3389/fphys.2011.00046
---------- VANCOUVER ----------
Solovey, G., Fraiman, D., Dawson, S.P. Mean field strategies induce unrealistic non-linearities in calcium puffs. Front. Physiol. 2011;2 AUG.
http://dx.doi.org/10.3389/fphys.2011.00046