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Abstract:

The Lateral Habenula (LHb) is a small brain structure that codifies negative motivational value and has been related to major depression. It has been shown recently that LHb activation is sufficient to induce aversive associative learning; however the key question about whether LHb activation is required for an aversive memory to be formed has not been addressed. In this article we studied the function of the LHb in memory formation using the Inhibitory Avoidance task (IA). We found that LHb inactivation during IA training does not disrupt memory when assessed 24 h after, but abolishes it 7 days later, indicating that LHb activity during memory acquisition is not necessary for memory formation, but regulates its temporal stability. These effects suggest that LHb inactivation modifies subjective perception of the training experience. © 2014 Tomaiuolo, Gonzalez, Medina and Piriz.

Registro:

Documento: Artículo
Título:Lateral Habenula determines long-term storage of aversive memories
Autor:Tomaiuolo, M.; Gonzalez, C.; Medina, J.H.; Piriz, J.
Filiación:Instituto de Biología Celular y Neurociencias, Universidad de Buenos Aires, Buenos Aires, Argentina
Departamento de Fisiología, Universidad de Buenos Aires, Buenos Aires, Argentina
Grupo de Neurociencia de Sistemas, Instituto de Fisiología y Biofísica Houssay (CONICET-UBA), Universidad de Buenos Aires, Buenos Aires, Argentina
Instituto de Fisiología Biología Molecular y Neurociencias (IFIBYNE-CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Fear memory; Inhibitory avoidance learning; Lateral Habenula; Memory persistence; Rats; Wistar; animal experiment; animal tissue; article; controlled study; elevated plus maze test; fear; habenula; lateral habenula; long term memory; male; memory consolidation; nonhuman; open field test; passive avoidance test; rat; state dependent learning
Año:2014
Volumen:8
Número:MAY
DOI: http://dx.doi.org/10.3389/fnbeh.2014.00170
Título revista:Frontiers in Behavioral Neuroscience
Título revista abreviado:Front. Behav. Neurosci.
ISSN:16625153
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16625153_v8_nMAY_p_Tomaiuolo

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Citas:

---------- APA ----------
Tomaiuolo, M., Gonzalez, C., Medina, J.H. & Piriz, J. (2014) . Lateral Habenula determines long-term storage of aversive memories. Frontiers in Behavioral Neuroscience, 8(MAY).
http://dx.doi.org/10.3389/fnbeh.2014.00170
---------- CHICAGO ----------
Tomaiuolo, M., Gonzalez, C., Medina, J.H., Piriz, J. "Lateral Habenula determines long-term storage of aversive memories" . Frontiers in Behavioral Neuroscience 8, no. MAY (2014).
http://dx.doi.org/10.3389/fnbeh.2014.00170
---------- MLA ----------
Tomaiuolo, M., Gonzalez, C., Medina, J.H., Piriz, J. "Lateral Habenula determines long-term storage of aversive memories" . Frontiers in Behavioral Neuroscience, vol. 8, no. MAY, 2014.
http://dx.doi.org/10.3389/fnbeh.2014.00170
---------- VANCOUVER ----------
Tomaiuolo, M., Gonzalez, C., Medina, J.H., Piriz, J. Lateral Habenula determines long-term storage of aversive memories. Front. Behav. Neurosci. 2014;8(MAY).
http://dx.doi.org/10.3389/fnbeh.2014.00170