Andino-Pavlovsky, V.; Souza, A.C.; Scheffer-Teixeira, R.; Tort, A.B.L.; Etchenique, R.; Ribeiro, S."Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats" (2017) Frontiers in Neural Circuits. 11
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Dopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning. To causally investigate whether dopamine release affects phase-amplitude comodulation between different frequencies in local field potentials (LFP) recorded from the medial PFC (mPFC) of behaving rats, we used RuBiDopa, a light-sensitive caged compound that releases the neurotransmitter dopamine when irradiated with visible light. LFP power did not change in any frequency band after the application of light-uncaged dopamine, but significantly strengthened phase-amplitude comodulation between delta and gamma oscillations. Saline did not exert significant changes, while injections of dopamine and RuBiDopa produced a slow increase in comodulation for several minutes after the injection. The results show that dopamine release in the medial PFC shifts phase-amplitude comodulation from theta-gamma to delta-gamma. Although being preliminary results due to the limitation of the low number of animals present in this study, our findings suggest that dopamine-mediated modification of the frequencies involved in comodulation could be a mechanism by which this neurotransmitter regulates functioning in mPFC. © 2017 Andino-Pavlovsky, Souza, Scheffer-Teixeira, Tort, Etchenique and Ribeiro.


Documento: Artículo
Título:Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats
Autor:Andino-Pavlovsky, V.; Souza, A.C.; Scheffer-Teixeira, R.; Tort, A.B.L.; Etchenique, R.; Ribeiro, S.
Filiación:Departamento de Química Inorganica, Analítica y Química Física, Instituto de Química Física de los Materiales, Medio Ambiente y Energía (INQUIMAE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Instituto do Cérebro, Federal University of Rio Grande do Norte, Natal, Brazil
Palabras clave:Comodulation; Delta-gamma coupling; Dopamine; LFP oscillation; Uncaging; dopamine; rubidopa; unclassified drug; 2,2' bipyridine; dichlorobis(2,2'-bipyridine)ruthenium; dopamine; organometallic compound; action potential amplitude; amplitude modulation; animal behavior; animal experiment; animal tissue; Article; brain function; controlled study; delta oscillation; dopamine release; electric potential; gamma oscillation; light irradiance; local field potential; male; medial prefrontal cortex; nonhuman; oscillation; rat; analogs and derivatives; animal; delta rhythm; drug effects; electroencephalography; gamma rhythm; metabolism; photostimulation; physiology; prefrontal cortex; procedures; REM sleep; spectroscopy; time factor; ultraviolet radiation; wakefulness; Wistar rat; 2,2'-Dipyridyl; Animals; Delta Rhythm; Dopamine; Electroencephalography; Gamma Rhythm; Male; Organometallic Compounds; Photic Stimulation; Prefrontal Cortex; Rats; Rats, Wistar; Sleep, REM; Spectrum Analysis; Time Factors; Ultraviolet Rays; Wakefulness
Título revista:Frontiers in Neural Circuits
Título revista abreviado:Front. Neural Circuits
CAS:dopamine, 51-61-6, 62-31-7; 2,2' bipyridine, 366-18-7; 2,2'-Dipyridyl; dichlorobis(2,2'-bipyridine)ruthenium; Dopamine; Organometallic Compounds


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---------- APA ----------
Andino-Pavlovsky, V., Souza, A.C., Scheffer-Teixeira, R., Tort, A.B.L., Etchenique, R. & Ribeiro, S. (2017) . Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats. Frontiers in Neural Circuits, 11.
---------- CHICAGO ----------
Andino-Pavlovsky, V., Souza, A.C., Scheffer-Teixeira, R., Tort, A.B.L., Etchenique, R., Ribeiro, S. "Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats" . Frontiers in Neural Circuits 11 (2017).
---------- MLA ----------
Andino-Pavlovsky, V., Souza, A.C., Scheffer-Teixeira, R., Tort, A.B.L., Etchenique, R., Ribeiro, S. "Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats" . Frontiers in Neural Circuits, vol. 11, 2017.
---------- VANCOUVER ----------
Andino-Pavlovsky, V., Souza, A.C., Scheffer-Teixeira, R., Tort, A.B.L., Etchenique, R., Ribeiro, S. Dopamine modulates delta-gamma phase-amplitude coupling in the prefrontal cortex of behaving rats. Front. Neural Circuits. 2017;11.