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Abstract:

Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we review earlier evidence and describe recent developments of ERK1/2 signaling in memory processing focusing the attention on the role of ERK1/2 in memory retrieval and reconsolidation, and in the maintenance of the memory trace including mechanisms involving the protection of labile memories. In addition, relearning requires ERK1/2 activity in selected brain regions. Its involvement in distinct memory stages points at ERK1/2 as a core element in memory processing and as one likely target to treat memory impairments associated with neurological disorders. © 2018 Medina and Viola.

Registro:

Documento: Artículo
Título:ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
Autor:Medina, J.H.; Viola, H.
Filiación:Instituto de Biología Celular y Neurociencias (IBCN) “Dr Eduardo De Robertis”, CONICET—Universidad de Buenos Aires, Buenos Aires, Argentina
Departamento de Fisiología, Biología Molecular y Celular “Dr. Hector Maldonado” (FBMC), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Durability; ERK1/2; Extinction; Long-term memory; Reconsolidation; Retrieval
Año:2018
Volumen:11
DOI: http://dx.doi.org/10.3389/fnmol.2018.00361
Título revista:Frontiers in Molecular Neuroscience
Título revista abreviado:Front. Mol. Neurosci.
ISSN:16625099
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16625099_v11_n_p_Medina

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Citas:

---------- APA ----------
Medina, J.H. & Viola, H. (2018) . ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory. Frontiers in Molecular Neuroscience, 11.
http://dx.doi.org/10.3389/fnmol.2018.00361
---------- CHICAGO ----------
Medina, J.H., Viola, H. "ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory" . Frontiers in Molecular Neuroscience 11 (2018).
http://dx.doi.org/10.3389/fnmol.2018.00361
---------- MLA ----------
Medina, J.H., Viola, H. "ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory" . Frontiers in Molecular Neuroscience, vol. 11, 2018.
http://dx.doi.org/10.3389/fnmol.2018.00361
---------- VANCOUVER ----------
Medina, J.H., Viola, H. ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory. Front. Mol. Neurosci. 2018;11.
http://dx.doi.org/10.3389/fnmol.2018.00361