Artículo

Moritz, M.I.G.; Marostica, L.L.; Bianco, É.M.; Almeida, M.T.R.; Carraro, J.L.; Cabrera, G.M.; Palermo, J.A.; Simões, C.M.O.; Schenkel, E.P. "Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity" (2014) Marine Drugs. 12(12):5864-5880
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Abstract:

Five new polyoxygenated marine steroids-punicinols A-E (1-5)-were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC50 values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel. © 2014 by the authors licensee MDPI Basel Switzerland.

Registro:

Documento: Artículo
Título:Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity
Autor:Moritz, M.I.G.; Marostica, L.L.; Bianco, É.M.; Almeida, M.T.R.; Carraro, J.L.; Cabrera, G.M.; Palermo, J.A.; Simões, C.M.O.; Schenkel, E.P.
Filiación:Post-Graduation Program in Pharmacy, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil
Invertebrates Department National Museum, Federal University of Rio de Janeiro, Rio de Janeiro RJ, 20940-040, Brazil
MYMFOR-Department of Organic Chemistry, FCEN, University of Buenos Aires, Buenos Aires, C1428EGA, Argentina
Palabras clave:A549 cells; Cytotoxic effects; Leptogorgia punicea; Lung cancer cells; Octocoral; Polyoxygenated steroids; cytotoxic agent; paclitaxel; punicinol A; punicinol B; punicinol C; punicinol D; punicinol E; unclassified drug; paclitaxel; steroid; A549 cell line; antiproliferative activity; Article; biological activity; carbon nuclear magnetic resonance; clonogenic assay; controlled study; coral; drug cytotoxicity; drug effect; drug isolation; drug potentiation; drug structure; IC50; in vitro study; infrared spectroscopy; Leptogorgia punicea; mass spectrometry; nonhuman; physical chemistry; proton nuclear magnetic resonance; animal; Anthozoa; cell cycle; chemistry; drug effects; human; Lung Neoplasms; nuclear magnetic resonance spectroscopy; procedures; tumor cell line; Gorgonia; Leptogorgia punicea; Animals; Anthozoa; Cell Cycle; Cell Line, Tumor; Drug Synergism; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Paclitaxel; Steroids
Año:2014
Volumen:12
Número:12
Página de inicio:5864
Página de fin:5880
DOI: http://dx.doi.org/10.3390/md12125864
Título revista:Marine Drugs
Título revista abreviado:Mar. Drugs
ISSN:16603397
CODEN:MDARE
CAS:paclitaxel, 33069-62-4; Paclitaxel; Steroids
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16603397_v12_n12_p5864_Moritz

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Citas:

---------- APA ----------
Moritz, M.I.G., Marostica, L.L., Bianco, É.M., Almeida, M.T.R., Carraro, J.L., Cabrera, G.M., Palermo, J.A.,..., Schenkel, E.P. (2014) . Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity. Marine Drugs, 12(12), 5864-5880.
http://dx.doi.org/10.3390/md12125864
---------- CHICAGO ----------
Moritz, M.I.G., Marostica, L.L., Bianco, É.M., Almeida, M.T.R., Carraro, J.L., Cabrera, G.M., et al. "Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity" . Marine Drugs 12, no. 12 (2014) : 5864-5880.
http://dx.doi.org/10.3390/md12125864
---------- MLA ----------
Moritz, M.I.G., Marostica, L.L., Bianco, É.M., Almeida, M.T.R., Carraro, J.L., Cabrera, G.M., et al. "Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity" . Marine Drugs, vol. 12, no. 12, 2014, pp. 5864-5880.
http://dx.doi.org/10.3390/md12125864
---------- VANCOUVER ----------
Moritz, M.I.G., Marostica, L.L., Bianco, É.M., Almeida, M.T.R., Carraro, J.L., Cabrera, G.M., et al. Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity. Mar. Drugs. 2014;12(12):5864-5880.
http://dx.doi.org/10.3390/md12125864