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Abstract:

A series of cationic drug-like substances with distinct basicity, hydrogen-bonding ability, and hydrophobicity, including three catecholamines, two beta-agonists, and thirteen beta-blockers, was successfully detected in a capillary electrophoresis system using an end-capillary coupled potentiometric sensor consisting of a PVC-based liquid membrane deposited directly on a 100 μm diameter copper rod. The electrophoretic separation was performed on a 72 cm × 75 μm id uncoated fused-silica capillary with an acidic background electrolyte containing phosphoric acid in a water-acetonitrile mixture, pH* 2.8. Samples were injected electrokinetically at 5.0 kV for 10 s and a running voltage of 19.5 kV was applied. Excluding the bufuralol/ practolol pair, baseline separation of all substances was achieved in the developed CE system within 9 minutes. A linear relationship (R2 0.8752) between the sensitivity of the applied potentiometric detector and the parameter log P characterising the hydrophobicity of the analytes was demonstrated. The best observable limits of detection (LODs) were obtained for the highly hydrophobic substances, i.e. bufuralol (8.10 × 10-8 M injected concentration, S/N = 3), propranolol, alprenolol, and clenbuterol (ca. 1.10 × 1017 M). In the case of hydrophilic catecholamines and carbuterol their LODs with potentiometric detection were lowered by a factor of almost one thousand, reaching a value of 6.6 × 10-5 M. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Registro:

Documento: Artículo
Título:Hydrophobicity-aided potentiometric detection of catecholamines, beta-agonists, and beta-blockers in a mixed-solvent capillary electrophoresis system
Autor:Bazylak, G.; Monge, M.E.; Everaert, J.; Negels, L.J.
Filiación:Department of Pharmaco-Bromatology and Molecular Nutrition, Faculty of Pharmacy, Nicolaus Copernicus University, Jagiellonska 13, PL 85-067 Bydgoszcz, Poland
Instituto de Quimica Fisica de Materiales, Ambiente y Energia (INQUIMAE), Departamento de Quimica Inorganica, Analytica y Quimica Fisica, Universidad de Buenos Aires, Buenos Aires, Argentina
Department of Chemistry, Faculty of Science, University of Antwerp, Antwerp, Belgium
Palabras clave:Aqueous-organic buffers; Basic drugs; Capillary electrophoresis; Potentiometry Neurotransmitters; Acetonitrile; Alkalinity; Amines; Brain; Capillary electrophoresis; Electrochemistry; Fused silica; Hormones; Hydrogen; Hydrophobicity; Liquid membranes; Phosphoric acid; Sensors; Silica; Alprenolol; Analytes; Aqueous-organic buffers; Back ground electrolytes; Baseline separations; Basic drugs; Beta-agonists; Beta-blockers; Cationic drugs; Ce systems; Clenbuterol; Copper rods; Electrophoretic separations; Fused-silica capillaries; Hydrogen bondings; Limits of detections; Linear relationships; Potentiometric detections; Potentiometric detectors; Potentiometry Neurotransmitters; Water-acetonitrile mixtures; Potentiometers (electric measuring instruments); alprenolol; beta adrenergic receptor blocking agent; beta adrenergic receptor stimulating agent; bisoprolol; bufuralol; carazolol; carbuterol; catecholamine; celiprolol; clenbuterol; dopamine; nadolol; oxprenolol; phosphoric acid; practolol; propranolol; tertatolol; tolamolol; carbuterol; ethanolamine derivative; solvent; analytic method; article; capillary electrophoresis; drug determination; drug structure; electric potential; hydrophobicity; potentiometry; priority journal; sensitivity analysis; separation technique; solvent effect; chemical structure; chemistry; methodology; potentiometry; reproducibility; sensitivity and specificity; time; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Catecholamines; Electrophoresis, Capillary; Ethanolamines; Hydrophobicity; Molecular Structure; Potentiometry; Reproducibility of Results; Sensitivity and Specificity; Solvents; Time Factors
Año:2009
Volumen:32
Número:1
Página de inicio:135
Página de fin:146
DOI: http://dx.doi.org/10.1002/jssc.200800450
Título revista:Journal of Separation Science
Título revista abreviado:J. Sep. Sci.
ISSN:16159306
CODEN:JSSCC
CAS:alprenolol, 13655-52-2, 13707-88-5, 39405-98-6, 58615-82-0; bisoprolol, 66722-44-9; bufuralol, 54340-62-4; carazolol, 57775-29-8; carbuterol, 34866-46-1, 34866-47-2; celiprolol, 56980-93-9, 57470-78-7; clenbuterol, 21898-19-1, 37148-27-9; dopamine, 51-61-6, 62-31-7; nadolol, 42200-33-9; oxprenolol, 22972-97-0, 6452-71-7, 6452-73-9; phosphoric acid, 7664-38-2; practolol, 6673-35-4; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; tertatolol, 33580-30-2, 34784-64-0; tolamolol, 38103-61-6; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; carbuterol, 34866-47-2; Catecholamines; Ethanolamines; Solvents
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16159306_v32_n1_p135_Bazylak

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Citas:

---------- APA ----------
Bazylak, G., Monge, M.E., Everaert, J. & Negels, L.J. (2009) . Hydrophobicity-aided potentiometric detection of catecholamines, beta-agonists, and beta-blockers in a mixed-solvent capillary electrophoresis system. Journal of Separation Science, 32(1), 135-146.
http://dx.doi.org/10.1002/jssc.200800450
---------- CHICAGO ----------
Bazylak, G., Monge, M.E., Everaert, J., Negels, L.J. "Hydrophobicity-aided potentiometric detection of catecholamines, beta-agonists, and beta-blockers in a mixed-solvent capillary electrophoresis system" . Journal of Separation Science 32, no. 1 (2009) : 135-146.
http://dx.doi.org/10.1002/jssc.200800450
---------- MLA ----------
Bazylak, G., Monge, M.E., Everaert, J., Negels, L.J. "Hydrophobicity-aided potentiometric detection of catecholamines, beta-agonists, and beta-blockers in a mixed-solvent capillary electrophoresis system" . Journal of Separation Science, vol. 32, no. 1, 2009, pp. 135-146.
http://dx.doi.org/10.1002/jssc.200800450
---------- VANCOUVER ----------
Bazylak, G., Monge, M.E., Everaert, J., Negels, L.J. Hydrophobicity-aided potentiometric detection of catecholamines, beta-agonists, and beta-blockers in a mixed-solvent capillary electrophoresis system. J. Sep. Sci. 2009;32(1):135-146.
http://dx.doi.org/10.1002/jssc.200800450