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Abstract:

Scope: Maternal diabetes can program metabolic and cardiovascular diseases in the offspring. The aim of this work was to address whether an olive oil supplemented diet during pregnancy can prevent lipid metabolic alterations in the heart of the offspring of mild diabetic rats. Methods and results: Control and diabetic Wistar rats were fed during pregnancy with either a standard diet or a 6% olive oil supplemented diet. The heart of adult offspring from diabetic rats showed increases in lipid concentrations (triglycerides in males and phospholipids, cholesterol, and free fatty acids in females), which were prevented with the maternal diets enriched in olive oil. Maternal olive oil supplementation increased the content of unsaturated fatty acids in the hearts of both female and male offspring from diabetic rats (possibly due to a reduction in lipoperoxidation), increased the expression of Δ6 desaturase in the heart of male offspring from diabetic rats, and increased the expression of peroxisome proliferator activated receptor α in the hearts of both female and male offspring from diabetic rats. Conclusion: Relevant alterations in cardiac lipid metabolism were evident in the adult offspring of a mild diabetic rat model, and regulated by maternal diets enriched in olive oil. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Registro:

Documento: Artículo
Título:Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil
Autor:Capobianco, E.; Pelesson, M.; Careaga, V.; Fornes, D.; Canosa, I.; Higa, R.; Maier, M.; Jawerbaum, A.
Filiación:Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
UMYMFOR (CONICET-UBA), Department of Organic Chemistry, School of Exact and Natural Sciences, University of Buenos Aires, Buenos Aires, Argentina
Palabras clave:Diabetes in pregnancy; Intrauterine programming; Lipid metabolism; Offspring's heart; Olive oil supplementation; fatty acid; linoleoyl coenzyme A desaturase; nitric oxide; olive oil; peroxisome proliferator activated receptor alpha; animal; body weight; cardiac muscle; diet therapy; dietary supplement; drug effects; experimental diabetes mellitus; female; heart; lipid metabolism; lipid peroxidation; male; metabolism; pregnancy; pregnancy diabetes mellitus; Wistar rat; Animals; Body Weight; Diabetes Mellitus, Experimental; Dietary Supplements; Fatty Acids; Female; Heart; Linoleoyl-CoA Desaturase; Lipid Metabolism; Lipid Peroxidation; Male; Myocardium; Nitric Oxide; Olive Oil; PPAR alpha; Pregnancy; Pregnancy in Diabetics; Rats, Wistar
Año:2015
Volumen:59
Número:10
Página de inicio:1997
Página de fin:2007
DOI: http://dx.doi.org/10.1002/mnfr.201500334
Título revista:Molecular Nutrition and Food Research
Título revista abreviado:Mol. Nutr. Food Res.
ISSN:16134125
CAS:linoleoyl coenzyme A desaturase, 9082-66-0; nitric oxide, 10102-43-9; olive oil, 8001-25-0; peroxisome proliferator activated receptor alpha, 147258-70-6; Fatty Acids; Linoleoyl-CoA Desaturase; Nitric Oxide; Olive Oil; PPAR alpha
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16134125_v59_n10_p1997_Capobianco

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Citas:

---------- APA ----------
Capobianco, E., Pelesson, M., Careaga, V., Fornes, D., Canosa, I., Higa, R., Maier, M.,..., Jawerbaum, A. (2015) . Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil. Molecular Nutrition and Food Research, 59(10), 1997-2007.
http://dx.doi.org/10.1002/mnfr.201500334
---------- CHICAGO ----------
Capobianco, E., Pelesson, M., Careaga, V., Fornes, D., Canosa, I., Higa, R., et al. "Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil" . Molecular Nutrition and Food Research 59, no. 10 (2015) : 1997-2007.
http://dx.doi.org/10.1002/mnfr.201500334
---------- MLA ----------
Capobianco, E., Pelesson, M., Careaga, V., Fornes, D., Canosa, I., Higa, R., et al. "Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil" . Molecular Nutrition and Food Research, vol. 59, no. 10, 2015, pp. 1997-2007.
http://dx.doi.org/10.1002/mnfr.201500334
---------- VANCOUVER ----------
Capobianco, E., Pelesson, M., Careaga, V., Fornes, D., Canosa, I., Higa, R., et al. Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil. Mol. Nutr. Food Res. 2015;59(10):1997-2007.
http://dx.doi.org/10.1002/mnfr.201500334