Artículo
Cabrerizo, F.M.; Dantola, M.L.; Thomas, A.H.; Lorente, C.; Braun, A.M.; Oliveros, E.; Capparelli, A.L. "Photooxidation of pterin in aqueous solutions: Biological and biomedical implications" (2004) Chemistry and Biodiversity. 1(11):1800-1811
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Abstract:
Studies of the photochemical reactivity of pterin (-2-aminopteridin-4(3H)- one; PT) in acidic (pH 5.0 -6.0) and alkaline (pH 10.2 - 10.8) aqueous solutions have been performed. The photochemical reactions were followed by UV/VIS spectrophotometry, thin layer chromatography (TLC), high-performance liquid chromatography (HPLC), and an enzymatic method for H2O2 determination. PT is not light-sensitive in the absence of molecular oxygen, but it undergoes photooxidation in the presence of O2 , yielding several nonpteridinic products. The quantum yields for PT disappearance were found to be 8.2 (-0.6)-10-4 and 1.2 (-0.2)-10-3 in acidic and alkaline media, respectively. H2O2 was detected and quantified in irradiated solutions of PT; and its importance from a biomedical point of view is discussed. The rate constant of the chemical reaction between singlet oxygen (1O2) and PT was determined to be 2.5 (-0.2)-105 l mol-1 s-1 in alkaline medium, and the role of 1O2 in the photooxidation of pterin was evaluated. © 2004 Verlag Helvetica Chimica Acta AG, Zürich.
Registro:
| Documento: | Artículo |
| Título: | Photooxidation of pterin in aqueous solutions: Biological and biomedical implications |
| Autor: | Cabrerizo, F.M.; Dantola, M.L.; Thomas, A.H.; Lorente, C.; Braun, A.M.; Oliveros, E.; Capparelli, A.L. |
| Filiación: | Instituto de Investigaciones Fisicoquímicas Teoricas y Aplicadas (INIFTA), Departamento de Química, Universidad Nacional de la Plata, CIC Casilla de Correo 16, Sucursal 4, 1900-La Plata, Argentina CHIDECAR - CONICET, Departamento de Química Organica, Universidad de Buenos Aires X, Pabellon 2, 3p, Ciudad Universitaria, 1428-Buenos Aires, Argentina Lehrstuhl fur Umweltmesstechnik, Engler-Bunte Institut, Universitat Karlsruhe, D-76128 Karlsruhe, Germany |
| Palabras clave: | pterin derivative; water; article; metabolism; oxidation reduction reaction; photochemistry; radiation exposure; solution and solubility; ultraviolet radiation; Oxidation-Reduction; Photochemistry; Pterins; Solutions; Ultraviolet Rays; Water |
| Año: | 2004 |
| Volumen: | 1 |
| Número: | 11 |
| Página de inicio: | 1800 |
| Página de fin: | 1811 |
| DOI: | http://dx.doi.org/10.1002/cbdv.200490135 |
| Título revista: | Chemistry and Biodiversity |
| Título revista abreviado: | Chem. Biodiversity |
| ISSN: | 16121872 |
| CODEN: | CBHIA |
| CAS: | pterin derivative, 948-60-7; water, 7732-18-5; Pterins; Solutions; Water, 7732-18-5 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16121872_v1_n11_p1800_Cabrerizo |
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Citas:
---------- APA ----------
Cabrerizo, F.M., Dantola, M.L., Thomas, A.H., Lorente, C., Braun, A.M., Oliveros, E. & Capparelli, A.L. (2004) . Photooxidation of pterin in aqueous solutions: Biological and biomedical implications. Chemistry and Biodiversity, 1(11), 1800-1811.http://dx.doi.org/10.1002/cbdv.200490135
---------- CHICAGO ----------
Cabrerizo, F.M., Dantola, M.L., Thomas, A.H., Lorente, C., Braun, A.M., Oliveros, E., et al. "Photooxidation of pterin in aqueous solutions: Biological and biomedical implications" . Chemistry and Biodiversity 1, no. 11 (2004) : 1800-1811.http://dx.doi.org/10.1002/cbdv.200490135
---------- MLA ----------
Cabrerizo, F.M., Dantola, M.L., Thomas, A.H., Lorente, C., Braun, A.M., Oliveros, E., et al. "Photooxidation of pterin in aqueous solutions: Biological and biomedical implications" . Chemistry and Biodiversity, vol. 1, no. 11, 2004, pp. 1800-1811.http://dx.doi.org/10.1002/cbdv.200490135
---------- VANCOUVER ----------
Cabrerizo, F.M., Dantola, M.L., Thomas, A.H., Lorente, C., Braun, A.M., Oliveros, E., et al. Photooxidation of pterin in aqueous solutions: Biological and biomedical implications. Chem. Biodiversity. 2004;1(11):1800-1811.http://dx.doi.org/10.1002/cbdv.200490135
