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Castro, M.A.; Olivares, M.C.A.; Putman, C.M.; Cebral, J.R. "Realistic comparison between aneurysmal wall shear stress vector and blood rheology in patient-specific computational hemodynamic models" (2013) Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging. 8672
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Abstract:

Wall shear stress plays an important role in the development of cerebrovascular pathologies. Its impact on aneurysm initiation, progress and rupture, was reported in previous works during the last years. However, there is still no wide agreement about what WSS characteristics are responsible for triggering those biomechanical processes. The accuracy of the simulations has been successfully validated in the past. Although the incorporation of the blood rheology in large arterial systems containing aneurysms resulted in similar hemodynamic characterizations for most aneurysms, large aneurysms, especially those containing blebs, are expected to have flow rates in the range where Newtonian and non- Newtonian models largely differ. However, there is no consent among authors about the impact of blood rheology on the intraaneurysmal WSS magnitude. In this work we used high resolution models reconstructed from rotational angiography images to perform unsteady finite element blood flow simulations to investigate the differences in WSS distribution and alignment for Newtonian and non-Newtonian rheologies. Unstructured finite element meshes were generated using an advancing front technique. Flow rate wave form was imposed at the inlets after scaling according to the Murray's Law for optimal arterial networks. The Casson model was incorporated as a velocity-dependent apparent viscosity and the results were compared to those using the Newtonian rheology. Associations between the localization of regions with large differences in wall shear stress magnitude and orientation, and the regions of differentiated wall shear stress magnitude were studied in a cohort of patients. © 2013 SPIE.

Registro:

Documento: Conferencia
Título:Realistic comparison between aneurysmal wall shear stress vector and blood rheology in patient-specific computational hemodynamic models
Autor:Castro, M.A.; Olivares, M.C.A.; Putman, C.M.; Cebral, J.R.
Ciudad:Lake Buena Vista, FL
Filiación:Grupo de Investigación Y Desarrollo en Bioingeniería, Facultad Regional Buenos Aire CONICET, Universidad Tecnológica Nacional, Medrano 951, Ciudad de Buenos Aires, CP 1179, Argentina
Ciencias Exactas y Naturales, Solís 453, Universidad Favaloro, Ciudad de Buenos Aires, CP 1078, Argentina
Inova Fairfax Hospital, Interventional Neuroradiology, 3300 Gallows Road, Falls Church, VA, United States
Center for Computational Fluid Dynamics, George Mason University, Fairfax, VA, United States
Palabras clave:Cerebral aneurysms; Computational fluid dynamics; Non-newtonian flow; Rotational angiography; Wall shear stress; Advancing front technique; Blood flow simulations; Cerebral Aneurysms; Computational hemodynamics; High-resolution models; Non-Newtonian rheology; Rotational angiography; Wall shear stress; Angiography; Biomechanics; Computational fluid dynamics; Elasticity; Flow rate; Hemodynamics; Medical applications; Molecular imaging; Non Newtonian flow; Rheology; Shear stress; Finite element method
Año:2013
Volumen:8672
DOI: http://dx.doi.org/10.1117/12.2005689
Título revista:Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging
Título revista abreviado:Progr. Biomed. Opt. Imaging Proc. SPIE
ISSN:16057422
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16057422_v8672_n_p_Castro

Referencias:

  • Taylor, C.A., Hughes, T.J.R., Zarins, C.K., Finite element modeling of blood flow in arteries (1998) Computational Methods in Applied Mechanical Engineering, 158, pp. 155-196
  • Steinman, D.A., Milner, J.S., Norley, C.J., Lownie, S.P., Holdsworth, D.W., Image-based computational simulation of flow dynamics in a giant intracranial aneurysm (2003) Am J Neurorad, 24 (4), pp. 553-554
  • Cebral, J.R., Castro, M.A., Appanaboyina, S., Putman, C.M., Millán, D., Frangi, A., Efficient pipeline for image-based patient-specific analysis of cerebral aneurysms hemodynamics: Technique and sensitivity (2005) IEEE - Transactions on Medical Imaging - Special Issue on Vascular Imaging, 24 (4), pp. 457-467
  • Castro, M.A., Putman, C.M., Cebral, J.R., Computational fluid dynamics modeling of intracranial aneurysms: Effects of parent artery segmentation on intraaneurysmal hemodynamics (2006) American Journal of Neuroradiology, 27, pp. 1703-1709
  • Nakatani, H., Hashimoto, N., Kang, H., Yamazoe, N., Kikuchi, H., Cerebral blood flow patterns at major vessel bifurcations and aneurysms in rats (1991) Journal of Neurosurgery, 74, pp. 258-262
  • Crompton, M., Mechanisms of growth and rupture in cerebral berry aneurysms (1966) British Journal of Medicine, 1, pp. 1138-1142
  • Castro, M.A., Putman, C.M., Cebral, J.R., Hemodynamic patterns of anterior communicating artery aneurysms: A possible association with rupture (2009) American Journal of Neuroradiology, 30 (2), pp. 297-302
  • Cebral, J.R., Mut, F., Weir, J., Putman, C.M., Quantitative characterization of the hemodynamic environment in ruptured and unruptured brain aneurysms (2011) American Journal of Neuroradiology, 32, pp. 145-151
  • Cebral, J.R., Sheridan, M., Putman, C.M., Hemodynamics and bleb formation in intracranial aneurysms (2010) American Journal of Neuroradiology, 31, pp. 304-310
  • Kulcsar, Z., Ugron, A., Marosfo, M., Berentei, Z., Paal, G., Szikora, I., Hemodynamics of cerebral aneurysm initiation: The role of wall shear stress and spatial wall shear stress gradient (2011) American Journal of Neuroradiology, 32 (3), pp. 587-594
  • Jou, L.D., Lee, D.H., Morsi, H., Mawad, M.E., Wall shear stress on ruptured and unruptured intracranial aneurysms at the internal carotid artery (2008) American Journal of Neuroradiology, 29, pp. 1761-1767
  • Shojima, M., Magnitude and role of wall shear stress on cerebral aneurysm: Computational fluid dynamic study of 20 middle cerebral aneurysms (2004) Stroke, 35, pp. 2500-2505
  • Shojima, M., Nemoto, S., Morita, A., Oshima, M., Watanabe, E., Saito, N., Role of shear stress in the blister formation of cerebral aneurysms (2010) Neurosurgery, 67 (5), pp. 1268-1275
  • Low, M., Perktold, K., Raunig, R., Hemodynamics in rigid and distensible saccular aneurysms: A numerical study of pulsatile flow characteristics (1993) Biorheology, 30, pp. 287-298
  • Khanafer, K.M., Gadhoke, P., Berguer, R., Bull, J.L., Modeling pulsatile flow in aortic aneurysms: Effect on non-Newtonian properties of blood (2006) Biorheology, 43, pp. 661-679
  • Fisher, C., Stroud Rossmann, J., Effects of non-newtonian behavior on hemodynamics of cerebral aneurysms (2009) Journal of Biomechanical Engineering, 31, pp. 1-9
  • Rayz, V.L., Boussel, L., Lawton, M.T., Acevedo-Bolton, G., Ge, L., Young, W.L., Higashida, R.T., Saloner, D., Numerical modeling of the flow in intracranial aneurysms: Prediction of regions prone to thrombus formation (2011) Annals of Biomedical Engineerings, 36, pp. 1793-1804
  • Xiang, J., Tremmel, M., Kolega, J., Levy, E., Natarajan, S., Meng, H., Newtonian viscosity model could overestimate wall shear stress in intracranial aneurysm domes and underestimated rupture risk (2011) J. Neurointerv Surg, 4 (5), pp. 351-357
  • Yim, P., Vasbinder, G.B., Ho, V.B., Choyke, P.L., Isosurfaces as deformable models for magnetic resonance angiography (2003) IEEE - Trans Med Imag, 22 (7), pp. 875-881
  • Löhner, R., Extensions and improvements of the advancing front grid generation technique (1996) Computational Methods in Applied Mechanical Engineering, 5, pp. 119-132
  • Löhner, R., Regridding surface triangulations (1996) Journal of Computational Physics, 126, pp. 1-10
  • Löhner, R., Automatic unstructured grid generators (1997) Finite Elements Analysis Design, 25, pp. 111-134
  • Pham, T.V., Mitsoulis, E., Entry and exit flows of Casson fluids (1994) Canadian Journal of Biomechanical Engineering, 72, pp. 1080-1084
  • Mazumdar, J.N., (1992) Biofluid Mechanics, , World Scientific, Singapore
  • Cebral, J.R., Castro, M.A., Putman, C.M., Alperin, N., Flow-area relationship in internal carotid and vertebral arteries (2008) Physiological Measurements, 29 (10), pp. 585-594
  • Sherman, T.F., On connecting large vessels to small, The meaning of Murray's law (1981) J Gen Physiol., 78, pp. 431-453
  • Womersley, J.R., Method for the calculation of velocity, rate of flow and viscous drag in arteries when the pressure gradient is known (1955) J Physiol, 127, pp. 553-563
  • Castro, M.A., Putman, C.M., Cebral, J.R., (2008) Computational Hemodynamics of Cerebral Aneurysms: Assessing the Risk of Rupture from Hemodynamic Patterns, , VDM Verlag, ISBN 9783639094411
  • Cebral, J.R., Castro, M.A., Soto, O., Löhner, R., Alperin, N., Blood flow models of the circle of Willis from magnetic resonance data (2003) J Eng Math, 47 (3-4), pp. 369-386
  • Cebral, J.R., Mut, F., Weir, J., Putman, C.M., Association of hemodynamic characteristics and cerebral aneurysm rupture (2011) Am J Neuroradiol, 32, pp. 264-270A4 - The Society of Photo-Optical Instrumentation Engineers (SPIE); Aeroflex Incorporated; CREOL - Univ. Central Florida, Coll. Opt. Photonics; DQE Instruments, Inc.; Medtronic, Inc.; PIXELTEQ, Multispectral Sensing and Imaging

Citas:

---------- APA ----------
Castro, M.A., Olivares, M.C.A., Putman, C.M. & Cebral, J.R. (2013) . Realistic comparison between aneurysmal wall shear stress vector and blood rheology in patient-specific computational hemodynamic models. Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, 8672.
http://dx.doi.org/10.1117/12.2005689
---------- CHICAGO ----------
Castro, M.A., Olivares, M.C.A., Putman, C.M., Cebral, J.R. "Realistic comparison between aneurysmal wall shear stress vector and blood rheology in patient-specific computational hemodynamic models" . Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging 8672 (2013).
http://dx.doi.org/10.1117/12.2005689
---------- MLA ----------
Castro, M.A., Olivares, M.C.A., Putman, C.M., Cebral, J.R. "Realistic comparison between aneurysmal wall shear stress vector and blood rheology in patient-specific computational hemodynamic models" . Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, vol. 8672, 2013.
http://dx.doi.org/10.1117/12.2005689
---------- VANCOUVER ----------
Castro, M.A., Olivares, M.C.A., Putman, C.M., Cebral, J.R. Realistic comparison between aneurysmal wall shear stress vector and blood rheology in patient-specific computational hemodynamic models. Progr. Biomed. Opt. Imaging Proc. SPIE. 2013;8672.
http://dx.doi.org/10.1117/12.2005689