Conferencia

Menéndez, G.; Roberti, M.J.; Sigot, V.; Etchehon, M.; Jovin, T.M.; Erijman, J.E.A. "Interplay of multivalency and optical properties of quantum dots: Implications for sensing and actuation in living cells" (2009) Colloidal Quantum Dots for Biomedical Applications IV. 7189
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Abstract:

Quantum dots (QDs) are unique probes due to their special properties (brightness, photostability, narrowband emission and broadband absorption), and excellent bio(chemical)compatibility for imaging structures and functions of living cells. When functionalized with ligands, they enable the recognition of specific targets and the tracking of dynamic processes for extended periods of time, detecting biomolecules with a sensitivity extending to the single molecule level. Thus, devices and probes based on such nanoparticles are very powerful tools for studying essential processes underlying the functions and regulation of living cells. Here we present nanosensors and nanoactuators based on QDs in which the multivalency of these particles plays an essential role in the functionality and sensing characteristics of the nanodevices. Two examples are discussed, the first being pH nanosensors based on the interplay of the multivalency and energy transfer between the nanoparticles and small molecules on their surface, and the second nanoactuators in which a controlled number of molecules of the amyloid protein α-synuclein (AS) specifically regulate the aggregation of fluorescently labeled bulk AS protein both in vitro and in live cells.©; 2009 SPIE.

Registro:

Documento: Conferencia
Título:Interplay of multivalency and optical properties of quantum dots: Implications for sensing and actuation in living cells
Autor:Menéndez, G.; Roberti, M.J.; Sigot, V.; Etchehon, M.; Jovin, T.M.; Erijman, J.E.A.
Ciudad:San Jose, CA
Filiación:Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), 1428 Buenos Aires, Argentina
Laboratory of Cellular Dynamics, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany
Laboratorio Max Planck de Dinámica Celular, FCEyN, UBA, Buenos Aires, Argentina
Palabras clave:α-synuclein; Amyloid protein aggregation; Confocal microscopy.; Imaging; Nanoeffectors; Parkinson's disease; pH nanosensors; Amyloid protein aggregation; Amyloid proteins; Broadband absorption; Dynamic process; Functionalized; Imaging; Imaging structure; In-vitro; Live cell; Living cell; Multivalency; Nano-devices; Nanoactuators; Nanoeffectors; Narrow-band emission; Parkinson's disease; Photo-stability; Quantum Dot; Quantum dots; Sensing characteristics; Single molecule level; Small molecules; Special properties; Synuclein; Cell membranes; Confocal microscopy; Energy transfer; Glycoproteins; Molecules; Nanoparticles; Nanosensors; Optical properties; Probes; Semiconductor quantum dots; Agglomeration
Año:2009
Volumen:7189
DOI: http://dx.doi.org/10.1117/12.816896
Título revista:Colloidal Quantum Dots for Biomedical Applications IV
Título revista abreviado:Progr. Biomed. Opt. Imaging Proc. SPIE
ISSN:16057422
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16057422_v7189_n_p_Menendez

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Citas:

---------- APA ----------
Menéndez, G., Roberti, M.J., Sigot, V., Etchehon, M., Jovin, T.M. & Erijman, J.E.A. (2009) . Interplay of multivalency and optical properties of quantum dots: Implications for sensing and actuation in living cells. Colloidal Quantum Dots for Biomedical Applications IV, 7189.
http://dx.doi.org/10.1117/12.816896
---------- CHICAGO ----------
Menéndez, G., Roberti, M.J., Sigot, V., Etchehon, M., Jovin, T.M., Erijman, J.E.A. "Interplay of multivalency and optical properties of quantum dots: Implications for sensing and actuation in living cells" . Colloidal Quantum Dots for Biomedical Applications IV 7189 (2009).
http://dx.doi.org/10.1117/12.816896
---------- MLA ----------
Menéndez, G., Roberti, M.J., Sigot, V., Etchehon, M., Jovin, T.M., Erijman, J.E.A. "Interplay of multivalency and optical properties of quantum dots: Implications for sensing and actuation in living cells" . Colloidal Quantum Dots for Biomedical Applications IV, vol. 7189, 2009.
http://dx.doi.org/10.1117/12.816896
---------- VANCOUVER ----------
Menéndez, G., Roberti, M.J., Sigot, V., Etchehon, M., Jovin, T.M., Erijman, J.E.A. Interplay of multivalency and optical properties of quantum dots: Implications for sensing and actuation in living cells. Progr. Biomed. Opt. Imaging Proc. SPIE. 2009;7189.
http://dx.doi.org/10.1117/12.816896