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Abstract:

Perinatal development represents a critical period in the life of an individual. A common cause of poor development is that which comes from undernutrition or malnutrition. In particular, protein deprivation during development has been shown to have deep deleterious effects on brain's growth and plasticity. Early-life stress has also been linked with an increased risk to develop different psychopathologies later in life. We have previously shown that perinatal protein malnutrition in mice leads to the appearance of anxiety-related behaviors in the adulthood. We also found evidence that the female offspring was more susceptible to the development of depression-related behaviors. In the present work, we further investigated this behavior together with its molecular bases. We focused our study on the hippocampus, as it is a structure involved in coping with stressful situations. We found an increase in immobility time in the forced swimming test in perinatally malnourished females, and an alteration in the expression of genes related with neuroplasticity, early growth response 1, calcineurin and c-fos. We also found that perinatal malnutrition causes a reduction in the number of neurons in the hippocampus. This reduction, together with altered gene expression, could be related to the increment in immobility time observed in the forced swimming test. © 2016 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society

Registro:

Documento: Artículo
Título:Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition
Autor:Belluscio, L.M.; Alberca, C.D.; Pregi, N.; Cánepa, E.T.
Filiación:Laboratorio de Neuroepigenética, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad de Buenos Aires, Argentina
Palabras clave:c-fos; Calcineurin; depressive-like behavior; early-life stress; Egr1; forced swimming test; hippocampus; malnutrition; mice; perinatal period; calcineurin; early growth response factor 1; protein c fos; adult; animal experiment; animal model; Article; behavior; controlled study; coping behavior; depression; female; forced swim test; gene expression; hippocampus; kwashiorkor; malnutrition; mouse; nerve cell plasticity; nonhuman; priority journal; animal; animal behavior; anxiety; depression; disease model; gene expression; genetics; hippocampus; male; mental stress; metabolism; pathophysiology; physiology; pregnancy; protein calorie malnutrition; psychology; Adaptation, Psychological; Animals; Anxiety; Behavior, Animal; Depression; Depressive Disorder; Disease Models, Animal; Female; Gene Expression; Hippocampus; Male; Mice; Neuronal Plasticity; Pregnancy; Protein-Energy Malnutrition; Stress, Psychological
Año:2016
Volumen:15
Número:8
Página de inicio:741
Página de fin:749
DOI: http://dx.doi.org/10.1111/gbb.12322
Título revista:Genes, Brain and Behavior
Título revista abreviado:Genes Brain Behav.
ISSN:16011848
CODEN:GBBEA
CAS:calcineurin, 137951-12-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16011848_v15_n8_p741_Belluscio

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Citas:

---------- APA ----------
Belluscio, L.M., Alberca, C.D., Pregi, N. & Cánepa, E.T. (2016) . Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition. Genes, Brain and Behavior, 15(8), 741-749.
http://dx.doi.org/10.1111/gbb.12322
---------- CHICAGO ----------
Belluscio, L.M., Alberca, C.D., Pregi, N., Cánepa, E.T. "Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition" . Genes, Brain and Behavior 15, no. 8 (2016) : 741-749.
http://dx.doi.org/10.1111/gbb.12322
---------- MLA ----------
Belluscio, L.M., Alberca, C.D., Pregi, N., Cánepa, E.T. "Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition" . Genes, Brain and Behavior, vol. 15, no. 8, 2016, pp. 741-749.
http://dx.doi.org/10.1111/gbb.12322
---------- VANCOUVER ----------
Belluscio, L.M., Alberca, C.D., Pregi, N., Cánepa, E.T. Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition. Genes Brain Behav. 2016;15(8):741-749.
http://dx.doi.org/10.1111/gbb.12322