Artículo

Pérez-Pérez, A.; Toro, A.; Vilariño-García, T.; Maymó, J.; Guadix, P.; Dueñas, J.L.; Fernández-Sánchez, M.; Varone, C.; Sánchez-Margalet, V. "Leptin action in normal and pathological pregnancies" (2018) Journal of Cellular and Molecular Medicine. 22(2):716-727
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Abstract:

Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin-producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre-eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy. © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Registro:

Documento: Artículo
Título:Leptin action in normal and pathological pregnancies
Autor:Pérez-Pérez, A.; Toro, A.; Vilariño-García, T.; Maymó, J.; Guadix, P.; Dueñas, J.L.; Fernández-Sánchez, M.; Varone, C.; Sánchez-Margalet, V.
Filiación:Department of Medical Biochemistry and Molecular Biology, Virgen Macarena University Hospital, University of Seville, Seville, Spain
Laboratory of Placental Molecular Physiology, Department of Biological Chemistry, School of Sciences, University of Buenos Aires, IQUIBICEN-CONICET, Buenos Aires, Argentina
Department of Obstetrics and Gynecology, Virgen Macarena University Hospital, University of Seville, Seville, Spain
Valencian Infertility Institute (IVI), Seville, Spain
Palabras clave:gestational diabetes; growth restriction; leptin; placenta; polycystic ovary syndrome; pre-eclampsia; recurrent miscarriage; reproduction; chorionic gonadotropin; gamma interferon; immunoglobulin enhancer binding protein; interleukin 1alpha; interleukin 1beta; interleukin 6; leptin; leptin receptor; protein bcl 2; tumor necrosis factor; apoptosis; blastocyst; cell proliferation; cytotoxicity; cytotrophoblast; female; gene expression; human; hyperleptinemia; immunomodulation; insulin resistance; intrauterine growth retardation; JAK-STAT signaling; MAPK signaling; nidation; nutritional status; ovary polycystic disease; preeclampsia; pregnancy diabetes mellitus; pregnancy disorder; priority journal; protein expression; protein phosphorylation; protein synthesis; Review; RNA metabolism; signal transduction; single nucleotide polymorphism; spontaneous abortion; syncytiotrophoblast; x-ray computed tomography
Año:2018
Volumen:22
Número:2
Página de inicio:716
Página de fin:727
DOI: http://dx.doi.org/10.1111/jcmm.13369
Título revista:Journal of Cellular and Molecular Medicine
Título revista abreviado:J. Cell. Mol. Med.
ISSN:15821838
CAS:chorionic gonadotropin, 9002-61-3; gamma interferon, 82115-62-6; protein bcl 2, 219306-68-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15821838_v22_n2_p716_PerezPerez

Referencias:

  • El Husseny, M.W., Mamdouh, M., Shaban, S., Adipokines: potential therapeutic targets for vascular dysfunction in type II diabetes mellitus and obesity (2017) J Diabetes Res, pp. 1-11. , https://doi.org/10.1155/2017/8095926
  • Münzberg, H., Morrison, C.D., Structure, production and signaling of leptin (2015) Metabolism, 64, pp. 13-23
  • Pérez-Pérez, A., Sánchez-Jiménez, F., Maymó, J., Role of leptin in female reproduction (2015) Clin Chem Lab Med, 53, pp. 15-28
  • Behnes, M., Brueckmann, M., Lang, S., Alterations of leptin in the course of inflammation and severe sepsis (2012) BMC Infect Dis, 12, p. 217
  • Lekva, T., Roland, M.C.P., Michelsen, A.E., Large reduction in adiponectin during pregnancy is associated with large for gestational age newborns (2017) J Clin Endocrinol Metab, 102, pp. 2552-2559
  • Bao, W., Baecker, A., Song, Y., Adipokine levels during the first or early second trimester of pregnancy and subsequent risk of gestational diabetes mellitus: a systematic review (2015) Metabolism, 64, pp. 756-764
  • Howell, K.R., Powell, T.L., Effects of maternal obesity on placental function and fetal development (2017) Reproduction, 153, pp. R97-108
  • Chehab, F.F., 20 YEARS OF LEPTIN: Leptin and reproduction: past milestones, present undertakings, and future endeavors (2014) J Endocrinol, 223, pp. T37-48
  • Friedman, J.M., Halaas, J.L., Leptin and the regulation of body weight in mammals (1998) Nature, 395, pp. 763-770
  • Park, H.-K., Ahima, R.S., Leptin signaling (2014) F1000prime Rep, 6, pp. 1-8
  • Hegyi, K., Fülöp, K., Kovács, K., Leptin-induced signal transduction pathways (2004) Cell Biol Int, 28, pp. 159-169
  • Wauman, J., Zabeau, L., Tavernier, J., The Leptin Receptor complex: heavier than expected? (2017) Front Endocrinol (Lausanne), 8, pp. 1-20
  • Turner, R.T., Philbrick, K.A., Kuah, A.F., Role of estrogen receptor signaling in skeletal response to leptin in female ob/ob mice (2017) J Endocrinol, 233, pp. 357-367
  • Herrid, M., Palanisamy, S.K., Ciller, U.A., An updated view of leptin on implantation and pregnancy: a review (2014) Physiol Res, 63, pp. 543-557
  • Martins, F.F., Aguila, M.B., Mandarim-de-Lacerda, C.A., Impaired steroidogenesis in the testis of leptin-deficient mice (ob/ob-/-) (2017) Acta Histochem, 119, pp. 508-515
  • Reitman, M.L., Bi, S., Marcus-Samuels, B., Leptin and its role in pregnancy and fetal development – an overview (2001) Biochem Soc Trans, 29, pp. 68-72
  • Pollheimer, J., Knofler, M., Signalling pathways regulating the invasive differentiation of human trophoblasts: a review (2005) Placenta, 26, pp. S21-30
  • Staun-Ram, E., Shalev, E., Human trophoblast function during the implantation process (2005) Reprod Biol Endocrinol, 3, p. 56
  • Carson, D.D., Bagchi, I., Dey, S.K., Embryo implantation (2000) Dev Biol, 223, pp. 217-237
  • E Davies, J., Pollheimer, J., Yong, H.E., Epithelial-mesenchymal transition during extravillous trophoblast differentiation (2016) Cell Adh Migr, 10, pp. 310-321
  • Weiss, G., Sundl, M., Glasner, A., The trophoblast plug during early pregnancy: a deeper insight (2016) Histochem Cell Biol, 146, pp. 749-756
  • Sheikh, A.M., Small, H.Y., Currie, G., Systematic review of micro-RNA expression in pre-eclampsia identifies a number of common pathways associated with the disease (2016) PLoS ONE, 11
  • Pérez-Pérez, A., Guadix, P., Maymó, J., Insulin and leptin signaling in placenta from gestational diabetic subjects (2016) Horm Metab Res, 48, pp. 62-69
  • King, J.C., Physiology of pregnancy and nutrient metabolism (2000) Am J Clin Nutr, 71, pp. 25-1218s
  • Elmquist, J.K., Anatomic basis of leptin action in the hypothalamus (2000) Front Horm Res, 26, pp. 21-41
  • Zhang, Y., Proenca, R., Maffei, M., Positional cloning of the mouse obese gene and its human homologue (1994) Nature, 372, pp. 425-432
  • Houseknecht, K.L., Portocarrero, C.P., Leptin and its receptors: regulators of whole-body energy homeostasis (1998) Domest Anim Endocrinol, 15, pp. 457-475
  • Hoggard, N., Haggarty, P., Thomas, L., Leptin expression in placental and fetal tissues: does leptin have a functional role? (2001) Biochem Soc Trans, 29, pp. 57-63
  • Masuzaki, H., Ogawa, Y., Sagawa, N., Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans (1997) Nat Med, 3, pp. 1029-1033
  • Acconcia, F., Kumar, R., Signaling regulation of genomic and nongenomic functions of estrogen receptors (2006) Cancer Lett, 238, pp. 1-14
  • González, R.R., Simón, C., Caballero-Campo, P., Leptin and reproduction (2000) Hum Reprod Update, 6, pp. 290-300
  • Sartori, C., Lazzeroni, P., Merli, S., From placenta to polycystic ovarian syndrome: the role of adipokines (2016) Mediators Inflamm, , https://doi.org/10.1155/2016/4981916, 14
  • Louis, G.W., Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis (2011) Endocrinology, 152, pp. 2302-2310
  • Jin, L., Zhang, S., Burguera, B.G., Leptin and leptin receptor expression in rat and mouse pituitary cells 1 (2000) Endocrinology, 141, pp. 333-339
  • Karlsson, C., Lindell, K., Svensson, E., Expression of functional leptin receptors in the human ovary 1 (1997) J Clin Endocrinol Metab, 82, pp. 4144-4148
  • Archanco, M., Muruzábal, F.J., Llopiz, D., Leptin expression in the rat ovary depends on estrous cycle (2003) J Histochem Cytochem, 51, pp. 1269-1277
  • Cioffi, J.A., Van Blerkom, J., Antczak, M., The expression of leptin and its receptors in pre-ovulatory human follicles (1997) Mol Hum Reprod, 3, pp. 467-472
  • Ricci, A.G., Di Yorio, M.P., Faletti, A.G., Inhibitory effect of leptin on the rat ovary during the ovulatory process (2006) Reproduction, 132, pp. 771-780
  • Farooqi, I.S., Jebb, S.A., Langmack, G., Effects of recombinant leptin therapy in a child with congenital leptin deficiency (1999) N Engl J Med, 341, pp. 879-884
  • Sir-Petermann, T., Recabarren, S.E., Lobos, A., Secretory pattern of leptin and LH during lactational amenorrhoea in breastfeeding normal and polycystic ovarian syndrome women (2001) Hum Reprod, 16, pp. 244-249
  • Cervero, A., Horcajadas, J.A., Domínguez, F., Leptin system in embryo development and implantation: a protein in search of a function (2005) Reprod Biomed Online, 10, pp. 217-223
  • Kawamura, K., Sato, N., Fukuda, J., Leptin promotes the development of mouse preimplantation embryos in vitro (2002) Endocrinology, 143, pp. 1922-1931
  • Bajoria, R., Sooranna, S.R., Ward, B.S., Prospective function of placental leptin at maternal-fetal interface (2002) Placenta, 23, pp. 103-115
  • Henson, M.C., Castracane, V.D., Leptin in pregnancy: an update (2006) Biol Reprod, 74, pp. 218-229
  • Lin, K.-C., Increase of maternal plasma leptin concentrations during pregnancy: comparison with nonpregnant women (1999) Kaohsiung J Med Sci, 15, pp. 640-645
  • Pérez-Pérez, A., Maymó, J., Dueñas, J.L., Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway (2008) Arch Biochem Biophys, 477, pp. 390-395
  • Pérez-Pérez, A., Maymó, J., Gambino, Y., Leptin stimulates protein synthesis-activating translation machinery in human trophoblastic cells (2009) Biol Reprod, 81, pp. 826-832
  • Toro, A.R., Maymó, J.L., Ibarbalz, F.M., Leptin is an anti-apoptotic effector in placental cells involving p53 downregulation (2014) PLoS ONE, 9. , doi.org/10.1371/journal.pone.0099187
  • Toro, A.R., Pérez-Pérez, A., Corrales Gutiérrez, I., Mechanisms involved in p53 downregulation by leptin in trophoblastic cells (2015) Placenta, 36, pp. 1266-1275
  • Pérez-Pérez, A., Toro, A.R., Vilarino-Garcia, T., Leptin reduces apoptosis triggered by high temperature in human placental villous explants: the role of the p53 pathway (2016) Placenta, 42, pp. 106-113
  • Magariños, M.P., Sánchez-Margalet, V., Kotler, M., Leptin promotes cell proliferation and survival of trophoblastic cells (2007) Biol Reprod, 76, pp. 203-210
  • Genbacev, O., Miller, R., Post-implantation differentiation and proliferation of cytotrophoblast cells: in vitro models—a review (2000) Placenta, 21, pp. S45-S49
  • Huppertz, B., Kadyrov, M., Kingdom, J.C., Apoptosis and its role in the trophoblast (2006) Am J Obstet Gynecol, 195, pp. 29-39
  • Martín-Romero, C., Santos-Alvarez, J., Goberna, R., Human leptin enhances activation and proliferation of human circulating T lymphocytes (2000) Cell Immunol, 199, pp. 15-24
  • Santos-Alvarez, J., Goberna, R., Sanchez-Margalet, V., Human leptin stimulates proliferation and activation of human circulating monocytes (1999) Cell Immunol, 194, pp. 6-11
  • Steppan, C.M., Crawford, D.T., Chidsey-Frink, K.L., Leptin is a potent stimulator of bone growth in ob/ob mice (2000) Regul Pept, 92, pp. 73-78
  • Najib, S., Sanchez-Margalet, V., Human leptin promotes survival of human circulating blood monocytes prone to apoptosis by activation of p42/44 MAPK pathway (2002) Cell Immunol, 220, pp. 143-149
  • Pérez-Pérez, A., Gambino, Y., Maymó, J., MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells (2010) Biochem Biophys Res Commun, 396, pp. 956-960
  • Ghilardi, N., Skoda, R.C., The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line (1997) Mol Endocrinol, 11, pp. 393-399
  • Kloek, C., Haq, A.K., Dunn, S.L., Regulation of Jak kinases by intracellular leptin receptor sequences (2002) J Biol Chem, 277, pp. 41547-41555
  • Corvinus, F.M., Fitzgerald, J.S., Friedrich, K., Evidence for a correlation between trophoblast invasiveness and STAT3 activity (2003) Am J Reprod Immunol, 50, pp. 316-321
  • Fumagalli, S., Totty, N.F., Hsuan, J.J., A target for Src in mitosis (1994) Nature, 368, pp. 871-874
  • Taylor, S.J., Shalloway, D., An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis (1994) Nature, 368, p. 867
  • Sánchez-Margalet, V., Martín-Romero, C., Santos-Alvarez, J., Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action (2003) Clin Exp Immunol, 133, pp. 11-19
  • Sánchez-Jiménez, F., Pérez-Pérez, A., González-Yanes, C., Leptin receptor activation increases Sam68 tyrosine phosphorylation and expression in human trophoblastic cells (2011) Mol Cell Endocrinol, 332, pp. 221-227
  • Sánchez-Jiménez, F., Pérez-Pérez, A., González-Yanes, C., Sam68 mediates leptin-stimulated growth by modulating leptin receptor signaling in human trophoblastic JEG-3 cells (2011) Hum Reprod, 26, pp. 2306-2315
  • Fitzgerald, J.S., Signal transduction in trophoblast invasion (2005) Immunology of gametes and embryo implantation, 88, pp. 181-199. , In, Karger Publishers
  • Hatano, N., Mori, Y., Oh-hora, M., Essential role for ERK2 mitogen-activated protein kinase in placental development (2003) Genes Cells, 8, pp. 847-856
  • Heazell, A.E., Lacey, H.A., Jones, C.J., Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast (2008) Placenta, 29, pp. 175-186
  • Sharp, A.N., Heazell, A.E., Crocker, I.P., Placental apoptosis in health and disease (2010) Am J Reprod Immunol, 64, pp. 159-169
  • Straszewski-Chavez, S.L., Abrahams, V.M., Alvero, A.B., The isolation and characterization of a novel telomerase immortalized first trimester trophoblast cell line, Swan 71 (2009) Placenta, 30, pp. 939-948
  • Maltepe, E., Bakardjiev, A.I., Fisher, S.J., The placenta: transcriptional, epigenetic, and physiological integration during development (2010) J Clin Investig, 120, pp. 1016-1025
  • Hutter, H., Hammer, A., Dohr, G., HLA expression at the maternal-fetal interface (1998) J Immunol Res, 6, pp. 197-204
  • Lappas, M., Rice, G., Phospholipase A 2 isozymes in pregnancy and parturition (2004) Prostaglandins Leukot Essent Fatty Acids, 70, pp. 87-100
  • Rice, G.E., Cytokines and the initiation of parturition (2001) The endocrinology of parturition, 27, pp. 113-146. , In, Karger Publishers
  • Lappas, M., Yee, K., Permezel, M., Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies (2005) J Endocrinol, 186, pp. 457-465
  • Lam, Q., Lu, L., Role of leptin in immunity (2007) Cell Mol Immunol, 4, pp. 1-13
  • Fernández-Riejos, P., Najib, S., Santos-Alvarez, J., Role of leptin in the activation of immune cells (2010) Mediator Inflamm, , https://doi.org/10.1155/2010/568343, 8
  • Fontana, V.A., Sanchez, M., Cebral, E., Interleukin-1β regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model (2010) Biocell, 34, pp. 37-43
  • Fontana, V.A., Sanchez, M., Cebral, E., Interferon-γ Inhibits metalloproteinase activity and cytotrophoblast cell migration (2010) Am J Reprod Immunol, 64, pp. 20-26
  • Cameo, P., Bischof, P., Calvo, J.C., Effect of leptin on progesterone, human chorionic gonadotropin, and interleukin-6 secretion by human term trophoblast cells in culture 1 (2003) Biol Reprod, 68, pp. 472-477
  • Soh, E., Mitchell, M., Keelan, J., Does leptin exhibit cytokine-like properties in tissues of pregnancy? (2000) Am J Reprod Immunol, 43, pp. 292-298
  • Lappas, M., Permezel, M., Georgiou, H.M., Nuclear factor kappa b regulation of proinflammatory cytokines in human gestational tissues in vitro 1 (2002) Biol Reprod, 67, pp. 668-673
  • Barrientos, G., Toro, A., Moschansky, P., Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways (2015) Placenta, 36, pp. 419-426
  • Pérez-Pérez, A., Maymó, J.L., Gambino, Y.P., Activated translation signaling in placenta from pregnant women with gestational diabetes mellitus: possible role of leptin (2013) Horm Metab Res, 45, pp. 436-442
  • Qiu, C., Williams, M.A., Vadachkoria, S., Increased maternal plasma leptin in early pregnancy and risk of gestational diabetes mellitus (2004) Obstet Gynecol, 103, pp. 519-525
  • Li, L., Lee, K.J., Choi, B.C., Relationship between leptin receptor and polycystic ovary syndrome (2013) Gene, 527, pp. 71-74
  • Sepilian, V.P., Crochet, J.R., Nagamani, M., Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens (2006) Fertil Steril, 85, pp. 1441-1447
  • Behboudi-Gandevani, S., Ramezani Tehrani, F., Bidhendi Yarandi, R., The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines (2017) J Endocrinol Invest, 40, pp. 859-866
  • De Leo, V., Musacchio, M.C., Cappelli, V., Genetic, hormonal and metabolic aspects of PCOS: an update (2016) Reprod Biol Endocrinol, 14, p. 38
  • Micić, D., Macut, D., Popović, V., Leptin levels and insulin sensitivity in obese and non-obese patients with polycystic ovary syndrome (1997) Gynecol Endocrinol, 11, pp. 315-320
  • Rizk, N.M., Sharif, E., Leptin as well as free leptin receptor is associated with polycystic ovary syndrome in young women (2015) Int J Endocrinol, 10. , http://dx.doi.org/10.1155/2015/927805
  • Brzechffa, P.R., Jakimiuk, A.J., Agarwal, S.K., Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome (1996) J Clin Endocrinol Metab, 81, pp. 4166-4169
  • Behboudi-Gandevani, S., Ramezani Tehrani, F., Bidhendi Yarandi, R., The association between polycystic ovary syndrome, obesity, and the serum concentration of adipokines (2017) J Endocrinol Invest, 40, pp. 859-866
  • Gambineri, A., Patton, L., Altieri, P., Polycystic ovary syndrome is a risk factor for type 2 diabetes (2012) Diabetes, 61, pp. 2369-2374
  • Daan, N.M., Koster, M.P., de Wilde, M.A., Biomarker profiles in women with PCOS and PCOS offspring. A pilot study (2016) PLoS ONE, 11
  • Zheng, S.-H., Du, D.-F., Li, X.-L., Leptin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis (2017) Reprod Sci, 24, pp. 656-670
  • Chakrabarti, J., Serum leptin level in women with polycystic ovary syndrome: correlation with adiposity, insulin, and circulating testosterone (2013) Ann Med Health Sci Res, 3, p. 191
  • Garrido-Gimenez, C., Alijotas-Reig, J., Recurrent miscarriage: causes, evaluation and management (2015) Postgrad Med J, 91, pp. 151-162
  • Zidan, H.E., Rezk, N.A., Alnemr, A.A., Interleukin-17 and leptin genes polymorphisms and their levels in relation to recurrent pregnancy loss in Egyptian females (2015) Immunogenetics, 67, pp. 665-673
  • Laird, S.M., Quinton, N.D., Anstie, B., Leptin and leptin-binding activity in women with recurrent miscarriage: correlation with pregnancy outcome (2001) Hum Reprod, 16, pp. 2008-2013
  • Kratzsch, J., Höckel, M., Kiess, W., Leptin and pregnancy outcome (2000) Curr Opin Obstet Gynecol, 12, pp. 501-505
  • Tommaselli, G.A., Di Spiezio Sardo, A., Di Carlo, C., Do serum leptin levels have a role in the prediction of pregnancy outcome in case of threatened miscarriage? (2006) Clin Endocrinol, 65, pp. 772-775
  • Rigó, J., Szendei, G., Rosta, K., Leptin receptor gene polymorphisms in severely pre-eclamptic women (2006) Gynecol Endocrinol, 22, pp. 521-525
  • Chin, J.R., Heuser, C.C., Eller, A.G., Leptin and leptin receptor polymorphisms and recurrent pregnancy loss (2013) J Perinatol, 33, pp. 589-592
  • Müller, A., Wagner, J., Hodžić, A., Genetic variation in leptin and leptin receptor genes is a risk factor for idiopathic recurrent spontaneous abortion (2016) Croat Med J, 57, pp. 566-571
  • Chiefari, E., Arcidiacono, B., Foti, D., Gestational diabetes mellitus: an updated overview (2017) J Endocrinol Invest, pp. 1-11
  • Ericsson, A., Säljö, K., Sjöstrand, E., Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transport (2007) J Physiol, 581, pp. 1323-1332
  • Taricco, E., Radaelli, T., Nobile de Santis, M.S., Foetal and placental weights in relation to maternal characteristics in gestational diabetes (2003) Placenta, 24, pp. 343-347
  • Desoye, G., Hauguel-de, S., Mouzon, The human placenta in gestational diabetes mellitus (2007) Diabetes Care, 30, pp. S120-S126
  • Araújo, J.R., Keating, E., Martel, F., Impact of gestational diabetes mellitus in the maternal-to-fetal transport of nutrients (2015) Curr DiabRep, 15, pp. 1-10
  • Powe, C.E., Early pregnancy biochemical predictors of gestational diabetes mellitus (2017) Curr DiabRep, 17, p. 12
  • Iciek, R., Wender-Ozegowska, E., Zawiejska, A., Placental leptin and its receptor genes expression in pregnancies complicated by type 1 diabetes (2013) J Physiol Pharmacol, 64, pp. 579-585
  • Lepercq, J., Cauzac, M., Lahlou, N., Overexpression of placental leptin in diabetic pregnancy: a critical role for insulin (1998) Diabetes, 47, pp. 847-850
  • Uzelac, P.S., Li, X., Lin, J., Dysregulation of leptin and testosterone production and their receptor expression in the human placenta with gestational diabetes mellitus (2010) Placenta, 31, pp. 581-588
  • Côté, S., Gagné-Ouellet, V., Guay, S.P., PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns (2016) Clin Epigenetics, 8, p. 72
  • Miehle, K., Stepan, H., Fasshauer, M., Leptin, adiponectin and other adipokines in gestational diabetes mellitus and pre-eclampsia (2012) Clin Endocrinol, 76, pp. 2-11
  • Pérez-Pérez, A., Maymó, J., Gambino, Y., Insulin enhances leptin expression in human trophoblastic cells (2013) Biol Reprod, 89, p. 20
  • Castro Parodi, M., Farina, M., Dietrich, V., Evidence for insulin-mediated control of AQP9 expression in human placenta (2011) Placenta, 32, pp. 1050-1056
  • Bednar, A.D., Beardall, M.K., Brace, R.A., Differential expression and regional distribution of aquaporins in amnion of normal and gestational diabetic pregnancies (2015) Physiol Rep, 3
  • Vilariño-García, T., Increased expression of aquaporin 9 in trophoblast from gestational diabetic patients (2016) Horm Metab Res, 48, pp. 535-539
  • Kingdom, J.C., Drewlo, S., Is heparin a placental anticoagulant in high-risk pregnancies? (2011) Blood, 118, pp. 4780-4788
  • Spradley, F.T., Palei, A.C., Granger, J.P., Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms (2015) Am J Physiol Regul Integr Comp Physiol, 309, pp. R1326-R1343
  • Song, Y., Gao, J., Qu, Y., Serum levels of leptin, adiponectin and resistin in relation to clinical characteristics in normal pregnancy and preeclampsia (2016) Clin Chim Acta, 458, pp. 133-137
  • Kalinderis, M., Papanikolaou, A., Kalinderi, K., Serum levels of leptin and IP-10 in preeclampsia compared to controls (2015) Arch Gynecol Obstet, 292, pp. 343-347
  • Taylor, B.D., Ness, R.B., Olsen, J., Serum leptin measured in early pregnancy is higher in women with preeclampsia compared with normotensive pregnant women novelty and significance (2015) Hypertension, 65, pp. 594-599
  • Chrelias, G., Makris, G.M., Papanota, A.M., Serum inhibin and leptin: risk factors for pre-eclampsia? (2016) Clin Chim Acta, 463, pp. 84-87
  • Doster, Y., Cetinkaya, D.B., Atalay, M.A., The possible role of serum leptin in preeclampsia (2015) Clin Exp Obstet Gynecol, 43, pp. 98-102
  • Kaufmann, P., Black, S., Huppertz, B., Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia (2003) Biol Reprod, 69, pp. 1-7
  • Zhang, S., Regnault, T.R., Barker, P.L., Placental adaptations in growth restriction (2015) Nutrients, 7, pp. 360-389
  • Dessì, A., Pravettoni, C., Cesare Marincola, F., The biomarkers of fetal growth in intrauterine growth retardation and large for gestational age cases: from adipocytokines to a metabolomic all-in-one tool (2015) Expert Rev Proteomics, 12, pp. 309-316
  • Briffa, J.F., McAinch, A.J., Romano, T., Leptin in pregnancy and development: a contributor to adulthood disease? (2015) Am J Physiol Endocrinol Metab, 308, pp. E335-E350
  • Scott-Finley, M., Woo, J.G., Habli, M., Standardization of amniotic fluid leptin levels and utility in maternal overweight and fetal undergrowth (2015) J Perinatol, 35, pp. 547-552
  • Catov, J.M., Patrick, T.E., Powers, R.W., Maternal leptin across pregnancy in women with small-for-gestational-age infants (2007) Am J Obstet Gynecol, 196. , e1-558
  • Laivuori, H., Gallaher, M.J., Collura, L., Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia (2006) Mol Hum Reprod, 12, pp. 551-556
  • Briana, D.D., Malamitsi-Puchner, A., Intrauterine growth restriction and adult disease: the role of adipocytokines (2009) Eur J Endocrinol, 160, pp. 337-347
  • Pighetti, M., Maternal serum and umbilical cord blood leptin concentrations with fetal growth restriction (2003) Obstet Gynecol, 102, pp. 535-543
  • Lepercq, J., Guerre-Millo, M., André, J., Leptin: a potential marker of placental insufficiency (2003) Gynecol Obstet Invest, 55, pp. 151-155
  • Milenković, S., Jankovic, B., Mirković, L., Lipids and adipokines in cord blood and at 72 h in discordant dichorionic twins (2017) Fetal Pediatr Pathol, 36, pp. 106-122
  • Davidson, S., Hod, M., Merlob, P., Leptin, insulin, insulin-like growth factors and their binding proteins in cord serum: insight into fetal growth and discordancy (2006) Clin Endocrinol, 65, pp. 586-592
  • Aydin, H.I., Eser, A., Kaygusuz, I., Adipokine, adropin and endothelin-1 levels in intrauterine growth restricted neonates and their mothers (2016) J Perinat Med, 44, pp. 669-676
  • Ferrero, S., Mazarico, E., Valls, C., Relationship between foetal growth restriction and maternal nutrition status measured by dual-energy X-ray absorptiometry, leptin, and insulin-like growth factor (2015) Gynecol Obstet Invest, 80, pp. 54-59
  • Broughton, D.E., Moley, K.H., Obesity and female infertility: potential mediators of obesity's impact (2017) Fertil Steril, 107, pp. 840-847
  • Friedman, J., The long road to leptin (2016) J Clin Investig, 126, pp. 4727-4734
  • Lee, J., Liu, J., Feng, X., Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice (2016) Nat Med, 22, pp. 1023-1032

Citas:

---------- APA ----------
Pérez-Pérez, A., Toro, A., Vilariño-García, T., Maymó, J., Guadix, P., Dueñas, J.L., Fernández-Sánchez, M.,..., Sánchez-Margalet, V. (2018) . Leptin action in normal and pathological pregnancies. Journal of Cellular and Molecular Medicine, 22(2), 716-727.
http://dx.doi.org/10.1111/jcmm.13369
---------- CHICAGO ----------
Pérez-Pérez, A., Toro, A., Vilariño-García, T., Maymó, J., Guadix, P., Dueñas, J.L., et al. "Leptin action in normal and pathological pregnancies" . Journal of Cellular and Molecular Medicine 22, no. 2 (2018) : 716-727.
http://dx.doi.org/10.1111/jcmm.13369
---------- MLA ----------
Pérez-Pérez, A., Toro, A., Vilariño-García, T., Maymó, J., Guadix, P., Dueñas, J.L., et al. "Leptin action in normal and pathological pregnancies" . Journal of Cellular and Molecular Medicine, vol. 22, no. 2, 2018, pp. 716-727.
http://dx.doi.org/10.1111/jcmm.13369
---------- VANCOUVER ----------
Pérez-Pérez, A., Toro, A., Vilariño-García, T., Maymó, J., Guadix, P., Dueñas, J.L., et al. Leptin action in normal and pathological pregnancies. J. Cell. Mol. Med. 2018;22(2):716-727.
http://dx.doi.org/10.1111/jcmm.13369