Registro:

Referencias:

• Besedovsky, H.O., del Rey, A., Immune-neuroendocrine circuits: Integrative role of cytokines (1992) Front Neuroendocrinol, 13, pp. 61-94
• Refojo, D., Liberman, A.C., Giacomini, D., Integrating systemic information at the molecular level: Cross-talk between steroid receptors and cytokine signaling on different target cells (2003) Ann N Y Acad Sci, 992, pp. 196-204
• Refojo, D., Liberman, A.C., Holsboer, F., Arzt, E., Transcription factormediated molecular mechanisms involved in the functional crosstalk between cytokines and glucocorticoids (2001) Immunol Cell Biol, 79, pp. 385-394
• Liberman, A.C., Refojo, D., Arzt, E., Cytokine signaling/transcription factor cross-talk in T cell activation and Th1-Th2 differentiation (2003) Arch Immunol Ther Exp (Warsz), 51, pp. 351-365
• Liberman, A.C., Druker, J., Garcia, F.A., Holsboer, F., Arzt, E., Intracellular molecular signaling. Basis for specificity to glucocorticoid anti-inflammatory actions (2009) Ann N Y Acad Sci, 1153, pp. 6-13
• Liberman, A.C., Druker, J., Perone, M.J., Arzt, E., Glucocorticoids in the regulation of transcription factors that control cytokine synthesis (2007) Cytokine Growth Factor Rev, 18, pp. 45-56
• Druker, J., Liberman, A.C., Acuna, M., Molecular understanding of cytokine-steroid hormone dialogue: Implications for human diseases (2006) Ann N Y Acad Sci, 1088, pp. 297-306
• Rhen, T., Cidlowski, J.A., Antiinflammatory action of glucocorticoids-new mechanisms for old drugs (2005) N Engl J Med, 353, pp. 1711-1723
• Stahn, C., Lowenberg, M., Hommes, D.W., Buttgereit, F., Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists (2007) Mol Cell Endocrinol, 275, pp. 71-78
• Schmidt, B.M., Gerdes, D., Feuring, M., Falkenstein, E., Christ, M., Wehling, M., Rapid, nongenomic steroid actions: A new age? (2000) Front Neuroendocrinol, 21, pp. 57-94
• Croxtall, J.D., Choudhury, Q., Flower, R.J., Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcriptionindependent mechanism (2000) Br J Pharmacol, 130, pp. 289-298
• Buttgereit, F., Scheffold, A., Rapid glucocorticoid effects on immune cells (2002) Steroids, 67, pp. 529-534
• Limbourg, F.P., Huang, Z., Plumier, J.C., Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids (2002) J Clin Invest, 110, pp. 1729-1738
• Buttgereit, F., Straub, R.H., Wehling, M., Burmester, G.R., Glucocorticoids in the treatment of rheumatic diseases: An update on the mechanisms of action (2004) Arthritis Rheum, 50, pp. 3408-3417
• Song, I.H., Gold, R., Straub, R.H., Burmester, G.R., Buttgereit, F., New Glucocorticoids on the Horizon: Repress, Don't Activate! (2005) J Rheumatol, 32, pp. 1199-1207
• Lowenberg, M., Tuynman, J., Bilderbeek, J., Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn (2005) Blood, 106, pp. 1703-1710
• Lowenberg, M., Verhaar, A.P., Bilderbeek, J., Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN (2006) EMBO Rep, 7, pp. 1023-1029
• Schacke, H., Schottelius, A., Docke, W.D., Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects (2004) Proc Natl Acad Sci USA, 101, pp. 227-232
• Thompson, E.B., Steroids, gene expression, and apoptosis: Recollections of contributions and controversies (1998) Steroids, 63, pp. 368-374
• Ismaili, N., Garabedian, M.J., Modulation of glucocorticoid receptor function via phosphorylation (2004) Ann N Y Acad Sci, 1024, pp. 86-101
• Pratt, W.B., Toft, D.O., Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery (2003) Exp Biol Med (Maywood), 228, pp. 111-133
• Savory, J.G., Hsu, B., Laquian, I.R., Discrimination between NL1-and NL2-mediated nuclear localization of the glucocorticoid receptor (1999) Mol Cell Biol, 19, pp. 1025-1037
• de Bosscher, K., Vanden Berghe, W., Haegeman, G., The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: Molecular mechanisms for gene repression (2003) Endocr Rev, 24, pp. 488-522
• Ashwell, J.D., Lu, F.W., Vacchio, M.S., Glucocorticoids in T cell development and function* (2000) Annu Rev Immunol, 18, pp. 309-345
• Becker, P.B., Gloss, B., Schmid, W., Strahle, U., Schutz, G., In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone (1986) Nature, 324, pp. 686-688
• Carrigan, A., Walther, R.F., Salem, H.A., An active nuclear retention signal in the glucocorticoid receptor functions as a strong inducer of transcriptional activation (2007) J Biol Chem, 282, pp. 10963-10971
• Meijsing, S.H., Elbi, C., Luecke, H.F., Hager, G.L., Yamamoto, K.R., The ligand binding domain controls glucocorticoid receptor dynamics independent of ligand release (2007) Mol Cell Biol, 27, pp. 2442-2451
• Felts, S.J., Toft, D.O., P23, a simple protein with complex activities (2003) Cell Stress Chaperones, 8, pp. 108-113
• Fletcher, T.M., Xiao, N., Mautino, G., ATP-dependent mobilization of the glucocorticoid receptor during chromatin remodeling (2002) Mol Cell Biol, 22, pp. 3255-3263
• Freeman, B.C., Felts, S.J., Toft, D.O., Yamamoto, K.R., The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies (2000) Genes Dev, 14, pp. 422-434
• John, S., Sabo, P.J., Johnson, T.A., Interaction of the glucocorticoid receptor with the chromatin landscape (2008) Mol Cell, 29, pp. 611-624
• Yoshinaga, S.K., Peterson, C.L., Herskowitz, I., Yamamoto, K.R., Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors (1992) Science, 258, pp. 1598-1604
• Cairns, B.R., Levinson, R.S., Yamamoto, K.R., Kornberg, R.D., Essential role of Swp73p in the function of yeast Swi/Snf complex (1996) Genes Dev, 10, pp. 2131-2144
• He, Y., Simons Jr., S.S., STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression (2007) Mol Cell Biol, 27, pp. 1467-1485
• Strahl, B.D., Briggs, S.D., Brame, C.J., Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1 (2001) Curr Biol, 11, pp. 996-1000
• Chen, D., Ma, H., Hong, H., Regulation of transcription by a protein methyltransferase (1999) Science, 284, pp. 2174-2177
• Banach, T., Zurowski, D., Gil, K., Weisbrodt, N.W., Rosenfeld, G., Thor, P.J., Peripheral mechanisms of intestinal dysmotility in the morphine tolerant and dependent rats (2006) J Physiol Pharmacol, 57, pp. 73-82
• Kleiman, A., Tuckermann, J.P., Glucocorticoid receptor action in beneficial and side effects of steroid therapy: Lessons from conditional knockout mice (2007) Mol Cell Endocrinol, 275, pp. 98-108
• Newton, R., Holden, N.S., Separating transrepression and transactivation: A distressing divorce for the glucocorticoid receptor? (2007) Mol Pharmacol, 72, pp. 799-809
• Tobler, A., Meier, R., Seitz, M., Dewald, B., Baggiolini, M., Fey, M.F., Glucocorticoids downregulate gene expression of GM-CSF, NAP-1/IL-8, and IL-6, but not of M-CSF in human fibroblasts (1992) Blood, 79, pp. 45-51
• Newton, R., Hart, L.A., Stevens, D.A., Effect of dexamethasone on interleukin-1beta-(IL-1beta)-induced nuclear factor-kappaB (NF-kappaB) and kappaB-dependent transcription in epithelial cells (1998) Eur J Biochem, 254, pp. 81-89
• Chivers, J.E., Gong, W., King, E.M., Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids (2006) Mol Pharmacol, 70, pp. 2084-2095
• Poon, M., Liu, B., Taubman, M.B., Identification of a novel dexamethasone-sensitive RNA-destabilizing region on rat monocyte chemoattractant protein 1 mRNA (1999) Mol Cell Biol, 19, pp. 6471-6478
• Lasa, M., Brook, M., Saklatvala, J., Clark, A.R., Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogenactivated protein kinase p38 (2001) Mol Cell Biol, 21, pp. 771-780
• Lai, W.S., Carballo, E., Strum, J.R., Kennington, E.A., Phillips, R.S., Blackshear, P.J., Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA (1999) Mol Cell Biol, 19, pp. 4311-4323
• Dean, J.L., Sully, G., Clark, A.R., Saklatvala, J., The involvement of AUrich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation (2004) Cell Signal, 16, pp. 1113-1121
• Zhao, Q., Shepherd, E.G., Manson, M.E., Nelin, L.D., Sorokin, A., Liu, Y., The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: Attenuation of proinflammatory cytokine biosynthesis via feedback control of p38 (2005) J Biol Chem, 280, pp. 8101-8108
• Lasa, M., Abraham, S.M., Boucheron, C., Saklatvala, J., Clark, A.R., Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38 (2002) Mol Cell Biol, 22, pp. 7802-7811
• Newton, R., Holden, N., Inhibitors of p38 mitogen-activated protein kinase: Potential as anti-inflammatory agents in asthma? (2003) Bio Drugs, 17, pp. 113-129
• Wesselborg, S., Bauer, M.K., Vogt, M., Schmitz, M.L., Schulze-Osthoff, K., Activation of transcription factor NF-kappaB and p38 mitogenactivated protein kinase is mediated by distinct and separate stress effector pathways (1997) J Biol Chem, 272, pp. 12422-12429
• Ayroldi, E., Riccardi, C., Glucocorticoid-induced leucine zipper (GILZ): A new important mediator of glucocorticoid action (2009) FASEB J
• Godot, V., Garcia, G., Capel, F., Dexamethasone and IL-10 stimulate glucocorticoid-induced leucine zipper synthesis by human mast cells (2006) Allergy, 61, pp. 886-890
• Eddleston, J., Herschbach, J., Wagelie-Steffen, A.L., Christiansen, S.C., Zuraw, B.L., The anti-inflammatory effect of glucocorticoids is mediated by glucocorticoid-induced leucine zipper in epithelial cells (2007) J Allergy Clin Immunol, 119, pp. 115-122
• Ayroldi, E., Zollo, O., Macchiarulo, A., Di Marco, B., Marchetti, C., Riccardi, C., Glucocorticoid-induced leucine zipper inhibits the Rafextracellular signal-regulated kinase pathway by binding to Raf-1 (2002) Mol Cell Biol, 22, pp. 7929-7941
• Webster, J.C., Jewell, C.M., Bodwell, J.E., Munck, A., Sar, M., Cidlowski, J.A., Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein (1997) J Biol Chem, 272, pp. 9287-9293
• Hittelman, A.B., Burakov, D., Iniguez-Lluhi, J.A., Freedman, L.P., Garabedian, M.J., Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins (1999) EMBO J, 18, pp. 5380-5388
• Itoh, M., Adachi, M., Yasui, H., Takekawa, M., Tanaka, H., Imai, K., Nuclear export of glucocorticoid receptor is enhanced by c-Jun Nterminal kinase-mediated phosphorylation (2002) Mol Endocrinol, 16, pp. 2382-2392
• Krstic, M.D., Rogatsky, I., Yamamoto, K.R., Garabedian, M.J., Mitogenactivated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor (1997) Mol Cell Biol, 17, pp. 3947-3954
• Rogatsky, I., Logan, S.K., Garabedian, M.J., Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun Nterminal kinase (1998) Proc Natl Acad Sci USA, 95, pp. 2050-2055
• Szatmary, Z., Garabedian, M.J., Vilcek, J., Inhibition of glucocorticoid receptor-mediated transcriptional activation by p38 mitogenactivated protein (MAP) kinase (2004) J Biol Chem, 279, pp. 43708-43715
• Irusen, E., Matthews, J.G., Takahashi, A., Barnes, P.J., Chung, K.F., Adcock, I.M., P38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma (2002) J Allergy Clin Immunol, 109, pp. 649-657
• Chen, M.S., Silverstein, A.M., Pratt, W.B., Chinkers, M., The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant (1996) J Biol Chem, 271, pp. 32315-32320
• Somers, J.P., Defranco, D.B., Effects of okadaic acid, a protein phosphatase inhibitor, on glucocorticoid receptor-mediated enhancement (1992) Mol Endocrinol, 6, pp. 26-34
• Defranco, D.B., Qi, M., Borror, K.C., Garabedian, M.J., Brautigan, D.L., Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors (1991) Mol Endocrinol, 5, pp. 1215-1228
• de Bosscher, K., Haegeman, G., Minireview: Latest perspectives on antiinflammatory actions of glucocorticoids (2009) Mol Endocrinol, 23, pp. 281-291
• Beato, M., Herrlich, P., Schutz, G., Steroid hormone receptors: Many actors in search of a plot (1995) Cell, 83, pp. 851-857
• Stocklin, E., Wissler, M., Gouilleux, F., Groner, B., Functional interactions between Stat5 and the glucocorticoid receptor (1996) Nature, 383, pp. 726-728
• Liberman, A.C., Refojo, D., Druker, J., The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction (2007) FASEB J, 21, pp. 1177-1188
• Ohtsuka, T., Kubota, A., Hirano, T., Glucocorticoid-mediated gene suppression of rat cytokine-induced neutrophil chemoattractant CINC/gro, a member of the interleukin-8 family, through impairment of NF-kappa B activation (1996) J Biol Chem, 271, pp. 1651-1659
• Mukaida, N., Morita, M., Ishikawa, Y., Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression (1994) J Biol Chem, 269, pp. 13289-13295
• Kleinert, H., Euchenhofer, C., Ihrig-Biedert, I., Forstermann, U., In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NF-kappaB (1996) J Biol Chem, 271, pp. 6039-6044
• Brostjan, C., Anrather, J., Csizmadia, V., Natarajan, G., Winkler, H., Glucocorticoids inhibit E-selectin expression by targeting NFkappaB and not ATF/c-Jun (1997) J Immunol, 158, pp. 3836-3844
• van de Stolpe, A., Caldenhoven, E., Stade, B.G., 12-Otetradecanoylphorbol-13-acetate-and tumor necrosis factor alphamediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter (1994) J Biol Chem, 269, pp. 6185-6192
• Simpson, C.S., Morris, B.J., Activation of nuclear factor kappaB by nitric oxide in rat striatal neurones: Differential inhibition of the p50 and p65 subunits by dexamethasone (1999) J Neurochem, 73, pp. 353-361
• Kurokouchi, K., Kambe, F., Kikumori, T., Effects of glucocorticoids on tumor necrosis factor alpha-dependent activation of nuclear factor kappaB and expression of the intercellular adhesion molecule 1 gene in osteoblast-like ROS17/2.8 cells (2000) J Bone Miner Res, 15, pp. 1707-1715
• Scheinman, R.I., Cogswell, P.C., Lofquist, A.K., Baldwin Jr., A.S., Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids (1995) Science, 270, pp. 283-286
• Auphan, N., Didonato, J.A., Rosette, C., Helmberg, A., Karin, M., Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis (1995) Science, 270, pp. 286-290
• Jonat, C., Rahmsdorf, H.J., Park, K.K., Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone (1990) Cell, 62, pp. 1189-1204
• Konig, H., Ponta, H., Rahmsdorf, H.J., Herrlich, P., Interference between pathway-specific transcription factors: Glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo (1992) EMBO J, 11, pp. 2241-2246
• Adcock, I.M., Ito, K., Barnes, P.J., Glucocorticoids: Effects on gene transcription (2004) Proc Am Thorac Soc, 1, pp. 247-254
• Lonard, D.M., O'Malley, B.W., Nuclear receptor coregulators: Judges, juries, and executioners of cellular regulation (2007) Mol Cell, 27, pp. 691-700
• Huang, Z.Q., Li, J., Sachs, L.M., Cole, P.A., Wong, J., A role for cofactorcofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription (2003) EMBO J, 22, pp. 2146-2155
• de Bosscher, K., Vanden Berghe, W., Haegeman, G., Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: Negative interference of activated glucocorticoid receptor with transcription factors (2000) J Neuroimmunol, 109, pp. 16-22
• de Bosscher, K., Vanden Berghe, W., Haegeman, G., Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators (2001) Mol Endocrinol, 15, pp. 219-227
• Ito, K., Jazrawi, E., Cosio, B., Barnes, P.J., Adcock, I.M., P65-activated histone acetyltransferase activity is repressed by glucocorticoids: Mifepristone fails to recruit HDAC2 to the p65-HAT complex (2001) J Biol Chem, 276, pp. 30208-30215
• Ito, K., Barnes, P.J., Adcock, I.M., Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12 (2000) Mol Cell Biol, 20, pp. 6891-6903
• Luecke, H.F., Yamamoto, K.R., The glucocorticoid receptor blocks PTEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression (2005) Genes Dev, 19, pp. 1116-1127
• Nissen, R.M., Yamamoto, K.R., The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain (2000) Genes Dev, 14, pp. 2314-2329
• Beck, I.M., Vanden Berghe, W., Vermeulen, L., Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition (2008) EMBO J, 27, pp. 1682-1693
• Heck, S., Kullmann, M., Gast, A., A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1 (1994) EMBO J, 13, pp. 4087-4095
• Liden, J., Delaunay, F., Rafter, I., Gustafsson, J., Okret, S., A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation (1997) J Biol Chem, 272, pp. 21467-21472
• Caldenhoven, E., Liden, J., Wissink, S., Negative cross-talk between RelA and the glucocorticoid receptor: A possible mechanism for the antiinflammatory action of glucocorticoids (1995) Mol Endocrinol, 9, pp. 401-412
• Scheinman, R.I., Gualberto, A., Jewell, C.M., Cidlowski, J.A., Baldwin Jr., A.S., Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors (1995) Mol Cell Biol, 15, pp. 943-953
• Liberman, A.C., Druker, J., Refojo, D., Holsboer, F., Arzt, E., Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells (2009) FASEB J, 23, pp. 1558-1571
• Maneechotesuwan, K., Yao, X., Ito, K., Suppression of GATA-3 nuclear import and phosphorylation: A novel mechanism of corticosteroid action in allergic disease (2009) PLoS Med, 6, pp. e1000076
• Ou, X.M., Chen, K., Shih, J.C., Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1 (2006) J Biol Chem, 281, pp. 21512-21525
• Tuckermann, J.P., Reichardt, H.M., Arribas, R., Richter, K.H., Schutz, G., Angel, P., The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin (1999) J Cell Biol, 147, pp. 1365-1370
• Reichardt, H.M., Kaestner, K.H., Tuckermann, J., DNA binding of the glucocorticoid receptor is not essential for survival (1998) Cell, 93, pp. 531-541
• Reichardt, H.M., Tuckermann, J.P., Gottlicher, M., Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor (2001) EMBO J, 20, pp. 7168-7173
• Tai, T.C., Claycomb, R., Her, S., Bloom, A.K., Wong, D.L., Glucocorticoid responsiveness of the rat phenylethanolamine N-methyltransferase gene (2002) Mol Pharmacol, 61, pp. 1385-1392
• Adams, M., Meijer, O.C., Wang, J., Bhargava, A., Pearce, D., Homodimerization of the glucocorticoid receptor is not essential for response element binding: Activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants (2003) Mol Endocrinol, 17, pp. 2583-2592
• Abraham, S.M., Lawrence, T., Kleiman, A., Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1 (2006) J Exp Med, 203, pp. 1883-1889
• Belvisi, M.G., Wicks, S.L., Battram, C.H., Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity (2001) J Immunol, 166, pp. 1975-1982
• Vayssiere, B.M., Dupont, S., Choquart, A., Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo (1997) Mol Endocrinol, 11, pp. 1245-1255
• de Bosscher, K., Vanden Berghe, W., Beck, I.M., A fully dissociated compound of plant origin for inflammatory gene repression (2005) Proc Natl Acad Sci USA, 102, pp. 15827-15832
• Dewint, P., Gossye, V., de Bosscher, K., A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis (2008) J Immunol, 180, pp. 2608-2615
• Zhang, Z., Zhang, Z.Y., Schluesener, H.J., Compound A, a plant origin ligand of glucocorticoid receptors, increases regulatory T cells and M2 macrophages to attenuate experimental autoimmune neuritis with reduced side effects (2009) J Immunol, 183, pp. 3081-3091
• So, A.Y., Chaivorapol, C., Bolton, E.C., Li, H., Yamamoto, K.R., Determinants of cell-and gene-specific transcriptional regulation by the glucocorticoid receptor (2007) PLoS Genet, 3, pp. e94
• Besedovsky, H.O., del Rey, A., Regulating inflammation by glucocorticoids (2006) Nat Immunol, 7, p. 537
• Leung, D.Y., Bloom, J.W., Update on glucocorticoid action and resistance (2003) J Allergy Clin Immunol, 111, pp. 3-22. , quiz 23
• Bauer, M.E., Papadopoulos, A., Poon, L., Altered glucocorticoid immunoregulation in treatment resistant depression (2003) Psychoneuroendocrinology, 28, pp. 49-65
• Bauer, M.E., Vedhara, K., Perks, P., Wilcock, G.K., Lightman, S.L., Shanks, N., Chronic stress in caregivers of dementia patients is associated with reduced lymphocyte sensitivity to glucocorticoids (2000) J Neuroimmunol, 103, pp. 84-92
• Luz, C., Collaziol, D., Preissler, T., da Cruz, I.M., Glock, L., Bauer, M.E., Healthy aging is associated with unaltered production of immunoreactive growth hormone but impaired neuroimmunomodulation (2006) Neuroimmunomodulation, 13, pp. 160-169
• Hearing, S.D., Norman, M., Smyth, C., Foy, C., Dayan, C.M., Wide variation in lymphocyte steroid sensitivity among healthy human volunteers (1999) J Clin Endocrinol Metab, 84, pp. 4149-4154
• van den Akker, E.L., Russcher, H., van Rossum, E.F., Glucocorticoid receptor polymorphism affects transrepression but not transactivation (2006) J Clin Endocrinol Metab, 91, pp. 2800-2803
• Webster, J.C., Oakley, R.H., Jewell, C.M., Cidlowski, J.A., Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative beta isoform: A mechanism for the generation of glucocorticoid resistance (2001) Proc Natl Acad Sci USA, 98, pp. 6865-6870
• Galigniana, M.D., Piwien-Pilipuk, G., Assreuy, J., Inhibition of glucocorticoid receptor binding by nitric oxide (1999) Mol Pharmacol, 55, pp. 317-323
• Wallace, A.D., Cidlowski, J.A., Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids (2001) J Biol Chem, 276, pp. 42714-42721
• Levitt, N.S., Lambert, E.V., Woods, D., Hales, C.N., Andrew, R., Seckl, J.R., Impaired glucose tolerance and elevated blood pressure in low birth weight, nonobese, young south african adults: Early programming of cortisol axis (2000) J Clin Endocrinol Metab, 85, pp. 4611-4618
• Reynolds, R.M., Walker, B.R., Syddall, H.E., Andrew, R., Wood, P.J., Whorwood, C.B., Phillips, D.I., Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors (2001) J Clin Endocrinol Metab, 86, pp. 245-250
• Edwards, C.R., Benediktsson, R., Lindsay, R.S., Seckl, J.R., Dysfunction of placental glucocorticoid barrier: Link between fetal environment and adult hypertension? (1993) Lancet, 341, pp. 355-357
• Chikanza, I.C., Kozaci, D.L., Corticosteroid resistance in rheumatoid arthritis: Molecular and cellular perspectives (2004) Rheumatology (Oxford), 43, pp. 1337-1345
• Seki, M., Ushiyama, C., Seta, N., Apoptosis of lymphocytes induced by glucocorticoids and relationship to therapeutic efficacy in patients with systemic lupus erythematosus (1998) Arthritis Rheum, 41, pp. 823-830
• Hearing, S.D., Norman, M., Probert, C.S., Haslam, N., Dayan, C.M., Predicting therapeutic outcome in severe ulcerative colitis by measuring in vitro steroid sensitivity of proliferating peripheral blood lymphocytes (1999) Gut, 45, pp. 382-388
• Williams, G.A., Haller, J.A., Kuppermann, B.D., Dexamethasone posterior-segment drug delivery system in the treatment of macular edema resulting from uveitis or Irvine-Gass syndrome (2009) Am J Ophthalmol, 147, pp. 1048-1054. , 1054 e1-2
• Munkholm, P., Langholz, E., Davidsen, M., Binder, V., Frequency of glucocorticoid resistance and dependency in Crohn's disease (1994) Gut, 35, pp. 360-362
• Leung, D., Superantigens, steroid insensitivity and innate immunity in atopic eczema (2005) Acta Derm Venereol Suppl (Stockh), pp. 11-15
• Faubion Jr., W.A., Loftus Jr., E.V., Harmsen, W.S., Zinsmeister, A.R., Sandborn, W.J., The natural history of corticosteroid therapy for inflammatory bowel disease: A population-based study (2001) Gastroenterology, 121, pp. 255-260
• Matysiak, M., Makosa, B., Walczak, A., Selmaj, K., Patients with multiple sclerosis resisted to glucocorticoid therapy: Abnormal expression of heat-shock protein 90 in glucocorticoid receptor complex (2008) Mult Scler, 14, pp. 919-926
• Fiorucci, E., Lucantoni, G., Paone, G., Colchicine, cyclophosphamide and prednisone in the treatment of mildmoderate idiopathic pulmonary fibrosis: Comparison of three currently available therapeutic regimens (2008) Eur Rev Med Pharmacol Sci, 12, pp. 105-111
• de Boeck, K., de Baets, F., Malfroot, A., Desager, K., Mouchet, F., Proesmans, M., Do inhaled corticosteroids impair long-term growth in prepubertal cystic fibrosis patients? (2007) Eur J Pediatr, 166, pp. 23-28
• Keatings, V.M., Jatakanon, A., Worsdell, Y.M., Barnes, P.J., Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD (1997) Am J Respir Crit Care Med, 155, pp. 542-548
• Yan, Z.Q., Hansson, G.K., Innate immunity, macrophage activation, and atherosclerosis (2007) Immunol Rev, 219, pp. 187-203
• Peter, J.V., John, P., Graham, P.L., Moran, J.L., George, I.A., Bersten, A., Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: Meta-analysis (2008) Br Med J, 336, pp. 1006-1009

Citas:

---------- APA ----------

---------- CHICAGO ----------

---------- MLA ----------

---------- VANCOUVER ----------