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Referencias:

• Berens, R.L., Marr, J.J., LaFon, S.W., Nelson, D.J., Purine metabolism in Trypanosoma cruzi (1981) Mol. Biochem. Parasitol., 3, pp. 187-196
• Sanchez-Sancho, F., Campillo, N.E., Paez, J.A., Chagas disease: Progress and new perspectives (2010) Curr. Med. Chem., 17, pp. 423-452
• Soeiro, M.N., De Castro, S.L., Trypanosoma cruzi targets for new chemotherapeutic approaches (2009) Expert Opin. Ther. Targets, 13, pp. 105-121
• Fasullo, M., Endres, L., Nucleotide salvage deficiencies, DNA damage and neurodegeneration (2015) Int. J. Mol. Sci., 16, pp. 9431-9449
• Nguyen, K.V., Nyhan, W.L., Lesch-Nyhan syndrome in a family with a deletion followed by an insertion within the HPRT1 gene (2015) Nucleosides Nucleotides Nucleic Acids, 34, pp. 442-447
• Partington, M.W., Hennen, B.K., The Lesch-Nyhan syndrome: Self-destructive biting, mental retardation, neurological disorder and hyperuricaemia (1967) Dev. Med. Child Neurol., 9, pp. 563-572
• Torres, R.J., Puig, J.G., Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome (2007) Orphanet J. Rare Dis., 2, p. 48
• Sculley, D.G., Dawson, P.A., Emmerson, B.T., Gordon, R.B., A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency (1992) Hum. Genet., 90, pp. 195-207
• Balendiran, G.K., Molina, J.A., Xu, Y., Torres-Martinez, J., Stevens, R., Focia, P.J., Eakin, A.E., Craig, S.P., III, Ternary complex structure of human HGPRTase, PRPP, Mg2 +, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding (1999) Protein Sci., 8, pp. 1023-1031
• Canyuk, B., Focia, P.J., Eakin, A.E., The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography (2001) Biochemistry, 40, pp. 2754-2765
• Focia, P.J., Craig, S.P., III, Eakin, A.E., Approaching the transition state in the crystal structure of a phosphoribosyltransferase (1998) Biochemistry, 37, pp. 17120-17127
• Focia, P.J., Craig, S.P., III, Nieves-Alicea, R., Fletterick, R.J., Eakin, A.E., A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi (1998) Biochemistry, 37, pp. 15066-15075
• Nieves-Alicea, R., Focia, P.J., Craig, S.P., III, Eakin, A.E., Limited proteolysis of a trypanosomal hypoxanthine phosphoribosyltransferase yields crystals that diffract X-rays to near atomic resolution (1998) Biochim. Biophys. Acta, 1388, pp. 500-505
• Canyuk, B., Medrano, F.J., Wenck, M.A., Focia, P.J., Eakin, A.E., Craig, S.P., III, Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase (2004) J. Mol. Biol., 335, pp. 905-921
• Allen, T.E., Ullman, B., Molecular characterization and overexpression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma cruzi (1994) Mol. Biochem. Parasitol., 65, pp. 233-245
• Heroux, A., White, E.L., Ross, L.J., Borhani, D.W., Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: Comparison of purine binding interactions with the XMP complex (1999) Biochemistry, 38, pp. 14485-14494
• Keough, D.T., Ng, A.L., Winzor, D.J., Emmerson, B.T., De Jersey, J., Purification and characterization of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase and comparison with the human enzyme (1999) Mol. Biochem. Parasitol., 98, pp. 29-41
• Monzani, P.S., Alfonzo, J.D., Simpson, L., Oliva, G., Thiemann, O.H., Cloning, characterization and preliminary crystallographic analysis of Leishmania hypoxanthine-guanine phosphoribosyltransferase (2002) Biochim. Biophys. Acta, 1598, pp. 3-9
• Monzani, P.S., Trapani, S., Thiemann, O.H., Oliva, G., Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase (2007) BMC Struct. Biol., 7, p. 59
• Winn, M.D., Ballard, C.C., Cowtan, K.D., Dodson, E.J., Emsley, P., Evans, P.R., Keegan, R.M., Wilson, K.S., Overview of the CCP4 suite and current developments (2011) Acta Crystallogr. D Biol. Crystallogr., 67, pp. 235-242
• Emsley, P., Cowtan, K., Coot: Model-building tools for molecular graphics (2004) Acta Crystallogr. D Biol. Crystallogr., 60, pp. 2126-2132
• Murshudov, G.N., Skubak, P., Lebedev, A.A., Pannu, N.S., Steiner, R.A., Nicholls, R.A., Winn, M.D., Vagin, A.A., REFMAC5 for the refinement of macromolecular crystal structures (2011) Acta Crystallogr. D Biol. Crystallogr., 67, pp. 355-367
• Curto, L.M., Caramelo, J.J., Delfino, J.M., Delta98delta, a functional all-beta-sheet abridged form of intestinal fatty acid binding protein (2005) Biochemistry, 44, pp. 13847-13857
• Faraj, S.E., Venturutti, L., Roman, E.A., Marino-Buslje, C.B., Mignone, A., Tosatto, S.C., Delfino, J.M., Santos, J., The role of the N-terminal tail for the oligomerization, folding and stability of human frataxin (2013) FEBS Open Bio, 3, pp. 310-320
• Noguera, M.E., Primo, M.E., Sosa, L.N., Risso, V.A., Poskus, E., Ermacora, M.R., Biophysical characterization of the membrane-proximal ectodomain of the receptor-type protein-tyrosine phosphatase phogrin (2013) Protein Pept. Lett., 20, pp. 1009-1017
• Lee, C.C., Medrano, F.J., Craig, S.P., III, Eakin, A.E., Investigation of the functional role of active site loop II in a hypoxanthine phosphoribosyltransferase (2001) Biochim. Biophys. Acta, 1537, pp. 63-70
• Fernandez, D., Wenck, M.A., Craig, S.P., III, Delfino, J.M., The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds (2004) Bioorg. Med. Chem. Lett., 14, pp. 4501-4504
• Neuberger, G., Maurer-Stroh, S., Eisenhaber, B., Hartig, A., Eisenhaber, F., Motif refinement of the peroxisomal targeting signal 1 and evaluation of taxon-specific differences (2003) J. Mol. Biol., 328, pp. 567-579
• Hausler, T., Stierhof, Y.D., Wirtz, E., Clayton, C., Import of a DHFR hybrid protein into glycosomes in vivo is not inhibited by the folate-analogue aminopterin (1996) J. Cell Biol., 132, pp. 311-324
• McNew, J.A., Goodman, J.M., An oligomeric protein is imported into peroxisomes in vivo (1994) J. Cell Biol., 127, pp. 1245-1257
• Medrano, F.J., Wenck, M.A., Eakin, A.E., Craig, S.P., III, Functional roles for amino acids in active site loop II of a hypoxanthine phosphoribosyltransferase (2003) Biochim. Biophys. Acta, 1650, pp. 105-116
• Scott, D.A., De Souza, W., Benchimol, M., Zhong, L., Lu, H.G., Moreno, S.N., Docampo, R., Presence of a plant-like proton-pumping pyrophosphatase in acidocalcisomes of Trypanosoma cruzi (1998) J. Biol. Chem., 273, pp. 22151-22158
• Montalvetti, A., Bailey, B.N., Martin, M.B., Severin, G.W., Oldfield, E., Docampo, R., Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase (2001) J. Biol. Chem., 276, pp. 33930-33937
• Szajnman, S.H., Montalvetti, A., Wang, Y., Docampo, R., Rodriguez, J.B., Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase (2003) Bioorg. Med. Chem. Lett., 13, pp. 3231-3235
• Urbina, J.A., Moreno, B., Vierkotter, S., Oldfield, E., Payares, G., Sanoja, C., Bailey, B.N., Docampo, R., Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs (1999) J. Biol. Chem., 274, pp. 33609-33615
• Ishida, T., Kinoshita, K., PrDOS: Prediction of disordered protein regions from amino acid sequence (2007) Nucleic Acids Res., 35, pp. W460-W464
• Linding, R., Jensen, L.J., Diella, F., Bork, P., Gibson, T.J., Russell, R.B., Protein disorder prediction: Implications for structural proteomics (2003) Structure, 11, pp. 1453-1459
• Shimizu, K., POODLE: Tools predicting intrinsically disordered regions of amino acid sequence (2014) Methods Mol. Biol., 1137, pp. 131-145
• Sickmeier, M., Hamilton, J.A., LeGall, T., Vacic, V., Cortese, M.S., Tantos, A., Szabo, B., Dunker, A.K., DisProt: The database of disordered proteins (2007) Nucleic Acids Res., 35, pp. D786-D793
• Dosztanyi, Z., Csizmok, V., Tompa, P., Simon, I., IUPred: Web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content (2005) Bioinformatics, 21, pp. 3433-3434
• Whitmore, L., Wallace, B.A., DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data (2004) Nucleic Acids Res., 32, pp. W668-W673
• Kabsch, W., Sander, C., Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features (1983) Biopolymers, 22, pp. 2577-2637

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