Navegar

Colección

Datos Estadísticas

Artículo

Paez-Pereda, M.; Giacomini, D.; Echenique, C.; Stalla, G.K.; Holsboer, F.; Arzt, E. "Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs" (2005) Current Drug Targets: Immune, Endocrine and Metabolic Disorders. 5(3):259-267
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Pituitary adenomas are neuroendocrine tumors that produce different endocrine and metabolic alterations, including hyperprolactinemia, acromegaly and Cushing's disease. These different clinical features of pituitary tumors are the result of the overproduction of hormones produced by the different pituitary cell types. Recent advances in the understanding of the signaling pathways that control hormone production in pituitary cells provide a source of potential therapeutic targets. In ACTH-secreting cells, the mechanisms that control hormone biosynthesis have been clarified to a great extent, indicating a number of protein kinases and ligand-activated nuclear receptors as targets for experimental drugs. ACTH production requires the activation of signal transduction through the PKA, the MAPK and the CamK pathways. These pathways activate nuclear receptors, including Nur and PPAR gamma. The inhibition of these kinases and nuclear receptors has been shown to produce therapeutic effects in mouse models of Cushing's syndrome. On the other hand, the signaling pathways that control prolactin and growth hormone production also have potential targets. It has been recently shown that SMAD proteins activated by growth factors of the TGF beta and BMP family interact with estrogen receptors to stimulate the proliferation of prolactin and growth hormone-secreting cells. Cytokines that bind to the membrane protein gp130 also stimulate the proliferation of these cells. The inhibition of both of these pathways results in the decrease of tumor growth in animal models of prolactinoma. Therefore, the study of signaling pathways that control hormone production and proliferation is a good source of candidate targets in pituitary tumors. © 2005 Bentham Science Publishers Ltd.

Registro:

Documento: Artículo
Título:Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs
Autor:Paez-Pereda, M.; Giacomini, D.; Echenique, C.; Stalla, G.K.; Holsboer, F.; Arzt, E.
Filiación:Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología y Biología Molecular y Celular, Universidad de Buenos Aires, Pabellón II, C1428EHA Buenos Aires, Argentina
Max-Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany
Palabras clave:1 [n,o bis(5 isoquinolinesulfonyl) n methyltyrosyl] 4 phenylpiperazine; 1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene; 2 (2 amino 3 methoxyphenyl)chromone; angiopeptin; bone morphogenetic protein; cell nucleus receptor; corticotropin; cyclic AMP dependent protein kinase; cytokine; estradiol; estrogen derivative; estrogen receptor; glycoprotein gp 130; growth hormone; hypophysis hormone; mitogen activated protein kinase; n (2 phenylcyclopentyl)azacyclotridecan 2 imine; n [2 (4 bromocinnamylamino)ethyl] 5 isoquinolinesulfonamide; nuclear receptor related factor 1; octreotide; peroxisome proliferator activated receptor gamma; prolactin; protein kinase (calcium,calmodulin); protein kinase C; retinoic acid receptor; retinol; rosiglitazone; Smad protein; transforming growth factor beta; unindexed drug; acromegaly; cancer inhibition; cell proliferation; cell type; clinical feature; Cushing syndrome; drug targeting; endocrine disease; enzyme activation; enzyme inhibition; hormonal regulation; hormone inhibition; hormone synthesis; human; hyperprolactinemia; hypophysis adenoma; hypophysis cell; metabolic disorder; neuroendocrine tumor; nonhuman; prolactin synthesis; prolactinoma; protein family; protein protein interaction; review; secretory cell; signal transduction; transcription regulation; Adrenocorticotropic Hormone; Animals; Cytokines; Drug Delivery Systems; Gene Expression Regulation; Humans; Neurosecretory Systems; Pituitary Neoplasms; Prolactin; Receptors, Cytokine; Signal Transduction; Transforming Growth Factor beta
Año:2005
Volumen:5
Número:3
Página de inicio:259
Página de fin:267
DOI: http://dx.doi.org/10.2174/1568008054863817
Título revista:Current Drug Targets: Immune, Endocrine and Metabolic Disorders
Título revista abreviado:Curr. Drug Targets: Immune, Endocr. Metab. Disord.
ISSN:15680088
CODEN:CDTIB
CAS:1 [n,o bis(5 isoquinolinesulfonyl) n methyltyrosyl] 4 phenylpiperazine, 127191-97-3; 1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene, 109511-58-2; 2 (2 amino 3 methoxyphenyl)chromone, 167869-21-8; angiopeptin, 113294-82-9; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; estradiol, 50-28-2; growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6; hypophysis hormone, 85883-81-4; mitogen activated protein kinase, 142243-02-5; n (2 phenylcyclopentyl)azacyclotridecan 2 imine, 40297-09-4; n [2 (4 bromocinnamylamino)ethyl] 5 isoquinolinesulfonamide, 127243-85-0; octreotide, 83150-76-9; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; protein kinase (calcium,calmodulin), 97350-82-8; protein kinase C, 141436-78-4; retinol, 68-26-8, 82445-97-4; rosiglitazone, 122320-73-4, 155141-29-0; Smad protein, 62395-38-4; Adrenocorticotropic Hormone, 9002-60-2; Cytokines; Prolactin, 9002-62-4; Receptors, Cytokine; Transforming Growth Factor beta
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15680088_v5_n3_p259_PaezPereda

Referencias:

  • Therrien, M., Drouin, J., (1991) Mol. Cell Biol., 11 (7), pp. 3492-3503
  • Philips, A., Lesage, S., Gingras, R., Maira, M.H., Gauthier, Y., Hugo, P., Drouin, J., (1997) Mol. Cell Biol., 17 (10), pp. 5946-5951
  • Boutillier, A.L., Monnier, D., Lorang, D., Lundblad, J.R., Roberts, J.L., Loeffler, J.P., (1995) Mol. Endocrinol., 9 (6), pp. 745-755
  • Bousquet, C., Zatelli, M.C., Melmed, S., (2000) J. Clin. Invest., 106 (11), pp. 1417-1425
  • Kovalovsky, D., Refojo, D., Liberman, A.C., Hochbaum, D., Pereda, M.P., Coso, O.A., Stalla, G.K., Arzt, E., (2002) Mol. Endocrinol., 16 (7), pp. 1638-1651
  • Páez-Pereda, M., Kovalovsky, D., Hopfner, U., Theodoropoulou, M., Pagotto, U., Uhl, E., Losa, M., Stalla, G., (2001) J. Clin. Invest., 108 (8), pp. 1123-1131
  • Heaney, A.P., Fernando, M., Yong, W.H., Melmed, S., (2002) Nat. Med., 8 (11), pp. 1281-1287
  • Lotan, R., (1996) FASEB J., 10 (9), pp. 1031-1039
  • Kishimoto, T., Akira, S., Mazaki, M., Taga, T., (1995) Blood, 86 (4), pp. 1243-1253
  • Senaldi, G., Varnum, B.C., Sarmiento, U., Starnes, C., Lile, J., Scully, S., Guo, J., Chang, M.S., (1999) Proc. Natl. Acad. Sci. USA, 96 (20), pp. 11458-11463
  • Kishimoto, T., Taga, T., Akira, S., (1994) Cell, 76 (2), pp. 253-262
  • Arzt, E., (2001) J. Clin. Invest., 108 (12), pp. 1729-1733
  • Hirano, T., (1994) The Cytokine Handbook, pp. 145-168. , (Thomson A. W., Ed) Academic Press, Osaka
  • Heinrich, P.C., Behrmann, I., Muller-Newen, G., Schaper, F., Graeve, L., (1998) Biochem. J., 334, pp. 297-314
  • Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P.C., Schaper, F., (2000) J. Biol. Chem., 275 (17), pp. 12848-12856
  • Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., Akira, S., (1997) Proc. Natl. Acad. Sci. USA, 94 (8), pp. 3801-3804
  • Yoshida, K., Taga, T., Saito, M., Suematsu, S., Kumanogoh, A., Tanaka, T., Fujiwara, H., Kishimoto, T., (1996) Proc. Natl. Acad. Sci. USA, 93 (1), pp. 407-411
  • Rodig, S.J., Meraz, M.A., White, J.M., Lampe, P.A., Riley, J.K., Arthur, C.D., Kind, K.L., Schreiber, R.D., (1998) Cell, 93 (3), pp. 373-383
  • Shimon, I., Yan, X., Ray, D.W., Melmed, S., (1997) J. Clin. Invest., 100 (2), pp. 357-363
  • Ohmichi, M., Hirota, K., Koike, K., Kurachi, H., Ohtsuka, S., Matsuzaki, N., Yamaguchi, M., Tanizawa, O., (1992) Neuroendocrinology, 55 (2), pp. 199-203
  • Akita, S., Webster, J., Ren, S.G., Takino, H., Said, J., Zand, O., Melmed, S., (1995) J. Clin. Invest., 95 (3), pp. 1288-1298
  • Wang, Z., Ren, S.G., Melmed, S., (1996) Endocrinology, 137 (7), pp. 2947-2953
  • Auernhammer, C.J., Melmed, S., (1999) Endocrinology, 140 (4), pp. 1559-1566
  • Perez Castro, C., Nagashima, A.C., Pereda, M.P., Goldberg, V., Chervin, A., Largen, P., Renner, U., Arzt, E., (2000) Endocrinology, 141 (5), pp. 1746-1753
  • Perez Castro, C., Carbia Nagashima, A., Paez Pereda, M., Goldberg, V., Chervin, A., Carrizo, G., Molina, H., Arzt, E., (2001) J. Endocrinol., 169 (3), pp. 539-547
  • Spangelo, B.L., MacLeod, R.M., Isakson, P.C., (1990) Endocrinology, 126 (1), pp. 582-586
  • Vankelecom, H., Carmeliet, P., Van Damme, J., Billiau, A., Denef, C., (1989) Neuroendocrinology, 49 (1), pp. 102-106
  • Arzt, E., Pereda, M.P., Castro, C.P., Pagotto, U., Renner, U., Stalla, G.K., (1999) Front. Neuroendocrinol., 20 (1), pp. 71-95
  • Ray, D., Melmed, S., (1997) Endocrine Rev., 18 (2), pp. 206-228
  • Spangelo, B.L., Gorospe, W.C., (1995) Front. Neuroendocrinol., 16 (1), pp. 1-12
  • Renner, U., Gloddek, J., Paez Pereda, M., Arzt, E., Stalla, G.K., (1998) Dom. Animal Endocr., 15 (5), pp. 353-362
  • Inoue, K., Matsumoto, H., Koyama, C., Shibata, K., Nakazato, Y., Ito, A., (1992) Endocrinology, 131 (6), pp. 3110-3116
  • Nagashima, A.C., Giacomini, D., Castro, C.P., Pereda, M.P., Renner, U., Stalla, G.K., Arzt, E., (2003) Mol. Cell Endocrinol., 201 (1-2), pp. 47-56
  • Lohrer, P., Gloddek, J., Nagashima, A.C., Korali, Z., Hopfner, U., Páez Pereda, M., Arzt, E., Renner, U., (2000) Endocrinology, 141 (12), pp. 4457-4465
  • Spangelo, B.L., Isakson, P.C., MacLeod, R.M., (1990) Endocrinology, 127 (1), pp. 403-409
  • Carmeliet, P., Vankelecom, H., Van Damme, J., Billiau, A., Denef, C., (1991) Neuroendocrinol., 53 (1), pp. 29-34
  • Schöbitz, B., Van En Dobbelsteen, M., Holsboer, F., Sutanto, W., De Kloet, E.R., (1993) Endocrinology, 132 (4), pp. 1569-1576
  • Lyson, K., McCann, S.M., (1991) Neuroendocrinol., 54 (3), pp. 262-266
  • Yamaguchi, M., Matsuzaki, N., Hirota, K., Miyake, A., Tanizawa, O., (1990) Acta Endocrinol., 122 (2), pp. 201-205
  • Arzt, E., Buric, R., Stelzer, G., Stalla, J., Sauer, J., Renner, U., Stalla, G.K., (1993) Endocrinology, 132 (1), pp. 459-467
  • Renner, U., Gloddek, J., Arzt, E., Inoue, K., Stalla, G.K., (1997) Exp. Clin. Endocrinol. Diabetes, 105 (6), pp. 345-352
  • Sawada, T., Koike, K., Kanda, Y., Ikegami, H., Jikihara, H., Maeda, T., Osako, Y., Miyake, A., (1995) J. Endocrinol. Invest., 18 (2), pp. 83-90
  • Castro, C.P., Giacomini, D., Nagashima, A.C., Onofri, C., Graciarena, M., Kobayashi, K., Paez-Pereda, M., Arzt, E., (2003) Endocrinology, 144 (2), pp. 693-700
  • Koyama, C., Matsumoto, H., Sakai, T., Wakabayashi, K., Ito, A., Couch, E.F., Inoue, K., (1995) Endocr. Pathol., 6 (1), pp. 67-75
  • Massague, J., (2000) Nat. Rev. Mol. Cell Biol., 1 (3), pp. 169-178
  • Massague, J., (1998) Annu. Rev. Biochem., 67, pp. 753-791
  • Shi, Y., Massague, J., (2003) Cell, 113 (6), pp. 685-700
  • Massague, J., Chen, Y.G., (2000) Genes Dev., 14 (6), pp. 627-644
  • Scully, K.M., Rosenfeld, M.G., (2002) Science, 295 (5563), pp. 2231-2235
  • Takumi, T., Moustakas, A., Lin, H.Y., Lodish, H.F., (1995) Exp. Cell Res., 216 (1), pp. 208-214
  • Moustakas, A., Takumi, T., Lin, H.Y., Lodish, H.F., (1995) J. Biol. Chem., 270 (2), pp. 765-769
  • Ying, C., Zhang, Z., Huang, G., Li, S.Q., Ying, S.Y., (1996) J. Endocrinol. Invest., 19 (1), pp. 6-11
  • Hentges, S., Pastorcic, M., De, A., Boyadjieva, N., Sarkar, D.K., (2000) Endocrinology, 141 (4), pp. 1528-1535
  • Hentges, S., Sarkar, D.K., (2001) Front. Neuroendocrinol., 22 (4), pp. 340-363
  • Hentges, S., Boyadjieva, N., Sarkar, D.K., (2000) Endocrinology, 141 (3), pp. 859-867
  • Renner, U., Lohrer, P., Schaaf, L., Feirer, M., Schmitt, K., Onofri, C., Arzt, E., Stalla, G.K., (2002) Endocrinology, 143 (10), pp. 3759-3765
  • Gold, L.I., (1999) Crit. Rev. Oncog., 10 (4), pp. 303-360
  • Yin, J.J., Selander, K., Chirgwin, J.M., Dallas, M., Grubbs, B.G., Wieser, R., Massague, J., Guise, T.A., (1999) J. Clin. Invest., 103 (2), pp. 197-206
  • Asa, S.L., Ezzat, S., (1998) Endocrine Rev., 19 (6), pp. 798-827
  • Renner, U., Pagotto, U., Arzt, E., Stalla, G.K., (1996) Eur. J. Endocrinol., 135 (5), pp. 515-532
  • Fujiwara, K., Ikeda, H., Yoshimoto, T., (1995) Acta Histochem., 97 (4), pp. 445-454
  • Alexander, J.M., Bikkal, H.A., Zervas, N.T., Laws Jr., E.R., Klibanski, A., (1996) J. Clin. Endocrinol. Metab., 81 (2), pp. 783-790
  • Stefaneanu, L., Kovacs, K., Lloyd, R.V., Scheithauer, B.W., Young Jr., W.F., Sano, T., Jin, L., (1992) Virchows Arch. B Cell Pathol. Incl. Mol. Pathol., 62 (5), pp. 291-296
  • Holmgren, U., Bergstrand, G., Hagenfeldt, K., Werner, S., (1986) Acta Endocrinol. (Copenh.), 111 (4), pp. 452-459
  • Garcia, M.M., Kapcala, L.P., (1995) J. Endocrinol. Invest., 18 (6), pp. 450-455
  • Lee, E.J., Duan, W.R., Jakacka, M., Gehm, B.D., Jameson, J.L., (2001) Endocrinology, 142 (9), pp. 3756-3763
  • Delidow, B.C., Billis, W.M., Agarwal, P., White, B.A., (1991) Mol. Endocrinol., 5 (11), pp. 1716-1722
  • Ramsdell, J.S., (1991) Endocrinology, 128 (4), pp. 1981-1990
  • Coffey Jr., R.J., Bascom, C.C., Sipes, N.J., Graves-Deal, R., Weissman, B.E., Moses, H.L., (1988) Mol. Cell Biol., 8 (8), pp. 3088-3093
  • Chen, C.R., Kang, Y., Massague, J., (2001) Proc. Natl. Acad. Sci. USA, 98 (3), pp. 992-999
  • Kelly, M.A., Rubinstein, M., Asa, S.L., Zhang, G., Saez, C., Bunzow, J.R., Allen, R.G., Low, M.J., (1997) Neuron, 19 (1), pp. 103-113
  • Asa, S.L., Kelly, M.A., Grandy, D.K., Low, M.J., (1999) Endocrinology, 141 (11), pp. 5348-5355
  • Paez-Pereda, M., Giacomini, D., Refojo, D., Nagashima, A.C., Hopfner, U., Grubler, Y., Chervin, A., Arzt, E., (2003) Proc. Natl. Acad. Sci. USA, 100 (3), pp. 1034-1039
  • Massague, J., Blain, S.W., Lo, R.S., (2000) Cell, 103 (2), pp. 295-309
  • Karsenty, G., (1999) Genes Dev., 13 (23), pp. 3037-3051
  • Matsuda, T., Yamamoto, T., Muraguchi, A., Saatcioglu, F., (2001) J. Biol. Chem., 276 (46), pp. 42908-42914
  • Takeda, M., Otsuka, F., Suzuki, J., Kishida, M., Ogura, T., Tamiya, T., Makino, H., (2003) Biochem. Biophys. Res. Commun., 306 (4), pp. 812-818

Citas:

---------- APA ----------
Paez-Pereda, M., Giacomini, D., Echenique, C., Stalla, G.K., Holsboer, F. & Arzt, E. (2005) . Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs. Current Drug Targets: Immune, Endocrine and Metabolic Disorders, 5(3), 259-267.
http://dx.doi.org/10.2174/1568008054863817
---------- CHICAGO ----------
Paez-Pereda, M., Giacomini, D., Echenique, C., Stalla, G.K., Holsboer, F., Arzt, E. "Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs" . Current Drug Targets: Immune, Endocrine and Metabolic Disorders 5, no. 3 (2005) : 259-267.
http://dx.doi.org/10.2174/1568008054863817
---------- MLA ----------
Paez-Pereda, M., Giacomini, D., Echenique, C., Stalla, G.K., Holsboer, F., Arzt, E. "Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs" . Current Drug Targets: Immune, Endocrine and Metabolic Disorders, vol. 5, no. 3, 2005, pp. 259-267.
http://dx.doi.org/10.2174/1568008054863817
---------- VANCOUVER ----------
Paez-Pereda, M., Giacomini, D., Echenique, C., Stalla, G.K., Holsboer, F., Arzt, E. Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs. Curr. Drug Targets: Immune, Endocr. Metab. Disord. 2005;5(3):259-267.
http://dx.doi.org/10.2174/1568008054863817