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Labeur, M.; Arzt, E.; Stalla, G.K.; Péz-Pereda, M. "New perspectives in the treatment of cushing's syndrome" (2004) Current Drug Targets: Immune, Endocrine and Metabolic Disorders. 4(4):335-342
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Abstract:

Regardless of etiology, all cases of endogenous Cushing's syndrome are due to increased production of cortisol by the adrenal gland. Most are caused by adrenocorticotrophic hormone (ACTH)-secreting pituitary adenomas. Alternatively, the glucocorticoid excess may be due to adrenal neoplasia or to ectopic ACTH-secreting tumors. Cushing's syndrome is characterized by endocrine and metabolic alterations such as truncal obesity, hypertension, weakness, amenorrhea, hyperglycemia, osteoporosis and depression. Unless treated, the disease is associated with high morbidity, and ultimately, mortality. Depending on the etiology of Cushing's syndrome two different treatment modalities are possible: reduction of pituitary ACTH production or reduction of adrenocortical cortisol secretion. In the absence of efficient drug therapy, transsphenoidal resection of the pituitary adenoma is the primary treatment of choice for the reduction of ACTH secretion. In the last years there was much progress in understanding the molecular mechanisms that control the function of the hypothalamic-pituitary-adrenal axis. Thus, new insights made it possible to identify potential drug targets for the treatment of Cushing's syndrome. The present article reviews different drug targets and therapeutic options including drugs that control the central ACTH regulation, e.g. by modulating signaling pathways and transcriptional regulation of ACTH biosynthesis, corticotrophin releasing hormone (CRH) or glucocorticoid receptor antagonists, inhibitors of glucocorticoid synthesis, ketoconazole, somatostatin and dopamine analogs. Some of these substances might be useful for the treatment of Cushing's syndrome. © 2004 Bentham Science Publishers Ltd.

Registro:

Documento: Artículo
Título:New perspectives in the treatment of cushing's syndrome
Autor:Labeur, M.; Arzt, E.; Stalla, G.K.; Péz-Pereda, M.
Filiación:Max Planck Institute of Psychiatry, Dept. of Endocrinology, Kraepelinstr. 10, 80804 Munich, Germany
Lab. Fisiologia Biologia Molecular, FCEN, Universidad de Buenos Aires, Pabellon 11, 1428 Buenos Aires, Argentina
Palabras clave:ACTH; Cushing's syndrome; Glucocorticoids; HPA axis; POMC; 1 [n,o bis(5 isoquinolinesulfonyl) n methyltyrosyl] 4 phenylpiperazine; 2 (2 amino 3 methoxyphenyl)chromone; 4 aminobutyrate aminotransferase inhibitor; aminoglutethimide; bromocriptine; cabergoline; corticotropin; corticotropin releasing factor; corticotropin releasing factor antagonist; cyproheptadine; cytokine receptor; dopamine derivative; dopamine receptor stimulating agent; glucocorticoid; glucocorticoid antagonist; glucocorticoid receptor antagonist; hormone receptor blocking agent; ketoconazole; metyrapone; mitotane; n (2 phenylcyclopentyl)azacyclotridecan 2 imine; n [2 (4 bromocinnamylamino)ethyl] 5 isoquinolinesulfonamide; octreotide; retinoic acid; rosiglitazone; serotonin antagonist; somatostatin derivative; unindexed drug; uo 126; valproic acid; adrenal disease; adrenal function; alopecia; amenorrhea; blood clotting disorder; clinical trial; corticotropin release; Cushing syndrome; depression; diarrhea; dizziness; dose response; drug efficacy; drug eruption; drug targeting; gastrointestinal symptom; glucose blood level; headache; hormonal regulation; hormone substitution; human; hydrocortisone release; hyperglycemia; hypertension; hypogonadism; hypophysis adenoma; hypothalamus hypophysis adrenal system; increased appetite; liver toxicity; molecular biology; morbidity; mortality; muscle hypotonia; muscle weakness; myalgia; nausea; nonhuman; obesity; osteoporosis; pathogenesis; pruritus; psychopathy; review; side effect; signal transduction; somnolence; taste disorder; transcription regulation; transsphenoidal hypophysectomy; vomiting; xerostomia; Adrenocorticotropic Hormone; Animals; Cushing Syndrome; Drug Delivery Systems; Humans; Receptors, Corticotropin-Releasing Hormone
Año:2004
Volumen:4
Número:4
Página de inicio:335
Página de fin:342
DOI: http://dx.doi.org/10.2174/1568008043339703
Título revista:Current Drug Targets: Immune, Endocrine and Metabolic Disorders
Título revista abreviado:Curr. Drug Targets: Immune, Endocr. Metab. Disord.
ISSN:15680088
CODEN:CDTIB
CAS:1 [n,o bis(5 isoquinolinesulfonyl) n methyltyrosyl] 4 phenylpiperazine, 127191-97-3; 2 (2 amino 3 methoxyphenyl)chromone, 167869-21-8; aminoglutethimide, 125-84-8; bromocriptine, 25614-03-3; cabergoline, 81409-90-7; corticotropin releasing factor, 9015-71-8; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; cyproheptadine, 129-03-3, 969-33-5; ketoconazole, 65277-42-1; metyrapone, 22752-91-6, 2405-72-3, 54-36-4, 908-35-0; mitotane, 53-19-0; n (2 phenylcyclopentyl)azacyclotridecan 2 imine, 40297-09-4; n [2 (4 bromocinnamylamino)ethyl] 5 isoquinolinesulfonamide, 127243-85-0; octreotide, 83150-76-9; retinoic acid, 302-79-4; rosiglitazone, 122320-73-4, 155141-29-0; valproic acid, 1069-66-5, 99-66-1; Adrenocorticotropic Hormone, 9002-60-2; Receptors, Corticotropin-Releasing Hormone
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15680088_v4_n4_p335_Labeur

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Citas:

---------- APA ----------
Labeur, M., Arzt, E., Stalla, G.K. & Péz-Pereda, M. (2004) . New perspectives in the treatment of cushing's syndrome. Current Drug Targets: Immune, Endocrine and Metabolic Disorders, 4(4), 335-342.
http://dx.doi.org/10.2174/1568008043339703
---------- CHICAGO ----------
Labeur, M., Arzt, E., Stalla, G.K., Péz-Pereda, M. "New perspectives in the treatment of cushing's syndrome" . Current Drug Targets: Immune, Endocrine and Metabolic Disorders 4, no. 4 (2004) : 335-342.
http://dx.doi.org/10.2174/1568008043339703
---------- MLA ----------
Labeur, M., Arzt, E., Stalla, G.K., Péz-Pereda, M. "New perspectives in the treatment of cushing's syndrome" . Current Drug Targets: Immune, Endocrine and Metabolic Disorders, vol. 4, no. 4, 2004, pp. 335-342.
http://dx.doi.org/10.2174/1568008043339703
---------- VANCOUVER ----------
Labeur, M., Arzt, E., Stalla, G.K., Péz-Pereda, M. New perspectives in the treatment of cushing's syndrome. Curr. Drug Targets: Immune, Endocr. Metab. Disord. 2004;4(4):335-342.
http://dx.doi.org/10.2174/1568008043339703