Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

In order to detect possible immunological effects of aluminum (Al) on lymph cells, mice were orally overloaded with pharmacological doses for 22 weeks. The in vitro response of lymph cells to mitogens (phytohemmaglutinin, PHA and concanavaline A, Con A) was examined at the end of the treatment. The chronic ingestion of Al affected the lymphatic nodes that were found to be 2- to 10-fold larger than those of the control mice. Concurrently, the in vitro proliferation of lymphatic node cells was found enhanced, while spleen cell cultures were unaffected. An acute direct action of Al on lymph cells from different sources was also examined. The blastogenic response to PHA of human peripheral lymphocytes was not disturbed by the presence of Al concentrations ranging from 0.09 to 900 μM. However, the response of mouse lymph cells was quite different, given that an Al dose-dependent inhibition was observed for lymphatic node cells, whereas for spleen cells the inhibition was only detected at Al concentrations higher than 90 μM. This work shows that Al might induce alterations in cell immune responses. The opposite results observed in mouse lymphatic node cells after in vitro and in vivo Al treatment, let us suggest that either the stimulating or suppressing effects of Al on the immune system might depend on the dose, route of administration and length of exposure, as well as on the cell population assayed. © 2001 Elsevier Science B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Dissimilar behavior of lymph cells in response to the action of aluminum. In vitro and in vivo studies
Autor:Lauricella, A.M.; Garbossa, G.; Nesse, A.
Filiación:Departamento De Química Biológica, Facultad De Ciencias Exactas Y Naturales, Ciudad Universitaria, 1428 Ciudad Autonoma de Buenos Aires, Argentina
Palabras clave:Aluminum; Aluminum toxicity; Immune system; Lymph nodes; Lymphocytes; Lymphoproliferative response; Spleen; aluminum citrate; concanavalin A; mitogenic agent; phytohemagglutinin; animal cell; animal experiment; animal model; animal tissue; article; cell population; cell proliferation; cellular immunity; controlled study; dose response; drug inhibition; drug mechanism; human; human cell; immune response; immune system; immunostimulation; in vitro study; in vivo study; lymph node; lymph node cell; lymphocyte transformation; male; mouse; nonhuman; peripheral lymphocyte; priority journal; spleen cell; Aluminum; Animals; Cell Division; Cells, Cultured; Concanavalin A; Humans; Lymph; Lymph Nodes; Mice; Mice, Inbred C3H; Mitogens; Phytohemagglutinins; Spleen
Año:2001
Volumen:1
Número:9-10
Página de inicio:1725
Página de fin:1732
DOI: http://dx.doi.org/10.1016/S1567-5769(01)00082-0
Título revista:International Immunopharmacology
Título revista abreviado:Int. Immunopharmacol.
ISSN:15675769
CODEN:IINMB
CAS:Aluminum, 7429-90-5; Concanavalin A, 11028-71-0; Mitogens; Phytohemagglutinins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15675769_v1_n9-10_p1725_Lauricella

Referencias:

  • French, P., Gardner, M.J., Gunn, A.M., Dietary aluminium and Alzheimer's disease (1989) Food Chem Toxicol, 27, pp. 495-498
  • Exley, C., Does antiperspirant use increase the risk of aluminium-related disease, including Alzheimer's disease? (1998) Mol Med Today, 4, pp. 107-109
  • Lione, A., Aluminium toxicity and the aluminium containing medication (1985) Pharmacol Ther, 29, pp. 255-284
  • Klein, G.L., The aluminum content of parenteral solutions: Current status (1991) Nutr Rev, 49, pp. 74-79
  • Rollinson, C.L., Aluminum coumpounds: Introduction (1979) Kirk-Othmer Encyclopedia of Chemical Technology, 2, pp. 188-196. , Kirk RE, Othmer DF, Grayson M, Eckroth D, editors. New York: Wiley
  • Busler, W.R., Aluminum compounds: Aluminates (1979) Kirk-Othmer Encyclopedia of Chemical Technology, 2, pp. 197-202. , Kirk RE, Othmer DF, Grayson M, Eckroth D, editors. New York: Wiley
  • Alfrey, A.C., Le Gendre, G.R., Kaehny, W.D., The dialysis encephalopathy syndrome. Possible aluminum intoxication (1976) N Engl J Med, 294, pp. 184-188
  • O'Hare, J.A., Murnaghan, D.J., Reversal of aluminum-induced hemodialysis anemia by a low-aluminum dialysate (1982) N Engl J Med, 306, pp. 654-656
  • Wills, M.R., Savory, J., Aluminum poisoning. Dialysis encephalopathy, osteomalacia, and anemia (1983) Lancet, 2, pp. 29-34
  • Hewitt, C.D., Savory, J., Wills, M.R., Aspects of aluminum toxicity (1990) Clin Lab Med, 10, pp. 403-422
  • Recker, R., Blotcky, A.J., Leffler, J.A., Rack, E.P., Evidence for aluminum absorption from the gastrointestinal tract and bone deposition by aluminum carbonate ingestion with normal renal function (1977) J Lab Clin Med, 90, pp. 810-815
  • Kaehny, W.D., Hegg, A.P., Alfrey, A.C., Gastrointestinal absorption of aluminum from aluminum-containing antacids (1977) N Engl J Med, 296, pp. 1389-1390
  • Tsou, V.M., Young, R.M., Hart, M., Vanderhoof, J.A., Elevated plasma aluminum levels in normal infants receiving antacids containing aluminum (1991) Pediatrics, 87, pp. 148-151
  • Garbossa, G., Gutnisky, A., Nesse, A., The inhibitory action of aluminum on mouse bone marrow cell growth: Evidence for an erythropoietin- and transferrin-mediated mechanism (1994) Miner Electrolyte Metab, 20, pp. 141-146
  • Garbossa, G., Gutnisky, A., Nesse, A., Depressed erythroid progenitor cell activity in aluminum-overloaded mice (1996) Miner Electrolyte Metab, 22, pp. 214-218
  • Nesse, A., Garbossa, G., Stripeikis, J., Gálvez, G., Castro, M.E., Aluminum accumulation in chronic renal failure affects erythropoiesis (1997) Nephrology, 3, pp. 347-351
  • Garbossa, G., Gálvez, G., Castro, M.E., Nesse, A., Oral aluminum administration to rats with normal renal function: I. Impairment of erythropoiesis (1998) Hum Toxicol, 17, pp. 312-317
  • Vittori, D., Nesse, A., Pérez, G., Garbossa, G., Morphological and functional alterations of erythroid cells induced by long-term ingestion of aluminum (1999) J Inorg Biochem, 76, pp. 113-120
  • Seibert, F.B., Wells, H.G., The effect of aluminum on mammalian blood and tissues (1929) Arch Pathol, 8, pp. 230-261
  • Zatta, P., Perazzolo, M., Corain, B., Tris acetylacetonate aluminium (III) induces osmotic fragility and acanthocyte formation in suspended erythrocytes (1989) Toxicol Lett, 45, pp. 15-21
  • Suwalsky, M., Ungerer, B., Villena, F., Norris, B., Cardenas, H., Zatta, P., Interactions of Al(acac) 3 with cell membranes and model phospholipid bilayer (1999) J Inorg Biochem, 75, pp. 263-268
  • Abreo, K., Glass, J., Sella, M., Aluminum inhibits hemoglobin synthesis but enhances iron uptake in Friend erythroleukemia cells (1990) Kidney Int, 37, pp. 677-681
  • Pérez, G., Garbossa, G., Sassetti, B., Di Risio, C., Nesse, A., Interference of aluminium on iron metabolism in erythroleukaemia K562 cells (1999) J Inorg Biochem, 76, pp. 105-112
  • Trapp, G.A., Plasma aluminum is bound to transferrin (1983) Life Sci, 33, pp. 311-316
  • Fatemi, S.J., Kadir, F.H., Moore, G.R., Aluminium transport in blood serum. Binding of aluminium by human transferrin in the presence of human albumin and citrate (1991) Biochem J, 280, pp. 527-532
  • McGregor, S., Naves, M., Oria, R., Vass, J.K., Brock, J.H., Effect of aluminium on iron uptake and transferrin-receptor expression by human erythroleukaemia cells (1990) Biochem J, 272, pp. 377-382
  • Brock, J.H., Mainou-Fowler, T., The role of iron and transferrin in lymphatic transformation (1983) Immunol Today, 4, pp. 347-351
  • Djeha, A., Brock, J.H., Effect of transferrin, lactoferrin and chelated iron on human T-lymphocytes (1992) Br J Haematol, 80, pp. 235-241
  • Nordal, K.P., Dahl, E., Albrechtsen, D., Halse, J., Leivestad, T., Aluminium accumulation and immunosuppressive effect in recipients of kidney transplants (1988) Br Med J, 297, pp. 1581-1582
  • Garrett, P., Aluminium accumulation and immunosuppression (1989) Br Med J, 298, p. 755
  • Davenport, A., Davison, A.M., Will, E.J., Newton, K.E., Toothill, C., Aluminium mobilization following renal transplantation and the possible effect on susceptibility to bacterial sepsis (1991) Q J Med, 289, pp. 407-423
  • Davenport, A., Davison, A.M., Newton, K.E., Toothill, C., Will, E.J., Aluminium mobilization following renal alograft transplantation may have an immunomodulatory role by reducing the incidence of graft rejection (1993) Nephrol Dial Transplant, 8, pp. 244-249
  • McGregor, S., Naves, M.L., Birly, A.K., Russell, N.H., Halls, D., Junor, B.J.R., Interaction of aluminium and gallium with human lymphocytes: The role of transferrin (1991) Biochim Biophys Acta, 1095, pp. 196-200
  • Teocharis, S., Margeli, A., Panayiotidis, P., Effects of various metals on DNA synthesis and lymphokines production by human peripheral blood lymphocytes in vitro (1991) Comp Biochem Physiol C, 99, pp. 131-133
  • Golub, M.S., Takeuchi, P.T., Gershwin, M.E., Yoshida, S.H., Influence of dietary aluminum on cytokine production by mitogen-stimulated spleen cells from Swiss Webster mice (1993) Immunopharmacol Immunotoxicol, 15, pp. 605-619
  • Yao, X.L., Jenkins, E.C., Wisniewski, H.M., Effect of aluminum chloride on mitogenesis, mitosis, and cell cycle in human short-term whole blood cultures: Lower concentrations enhance mitosis (1994) J Cell Biochem, 54, pp. 473-477
  • Tzanno-Martins, C., Azevedo, L.S., Tanji, M., Tanji, M.C., Sabbaga, E., The role of experimental aluminum intoxication in allogeneic immunoresponse (1995) Transplant Int, 8, pp. 396-398
  • Glynn, A.W., Thuvander, A., Sundstrom, B., Sparen, A., Danielsson, L.G., Jorhem, L., Does aluminium stimulate the immune system in male rats after oral exposure? (1999) Food Addit Contam, 16, pp. 129-135
  • Bradley, L.M., Cell proliferation (1980) Selected Methods in Cellular Immunology, pp. 153-172. , Mishell B, Shiigi M, editors. Freeman San Francisco
  • Boyum, A., A one-stage procedure for isolation of granulocytes and lymphocytes from human blood. General sedimentation properties of white blood cells in a 1 g gravity field (1968) Scand J Clin Lab Invest, 21 (SUPPL. 97), pp. 51-76
  • MacDonald, C., Primary cultures and the establishment of cell lines (1994) Basic Cell Culture. A Practical Approach, pp. 149-180. , Davis JM, editor. Oxford Univ. Press New York
  • Nestel, A.W., Meyers, A.M., Paiker, J., Rollin, H.B., Effect of calcium supplement preparation containing small amounts of citrate on the absorption of aluminium in normal subjects and in renal failure patients (1994) Nephron, 68, pp. 197-210
  • Garbossa, G., Gálvez, G., Pérez, G., Stripeikis, J., Tudino, M., Nesse, A., Oral aluminum administration to rats with normal renal function: 2. Body distribution (1998) Hum Toxicol, 17, pp. 318-322
  • Flarend, R.E., Hem, S.L., White, J.L., Elmore, D., Suckow, M.A., Rudy, A.C., In vivo absorption of aluminium-containing vaccine adjuvants using 26 Al (1997) Vaccine, 15, pp. 1314-1318
  • Hilman, B.C., Wahid, R., Negrich, R., Menon, P., Abreo, F., Veillon, D., Immunodeficiency with elevated IgM, lymphoid hyperplasia, autoimmune anemia, and thrombocytopenia (1998) Ann Allergy Asthma Immunol, 80, pp. 441-451
  • Kapadia, S.B., Wiley, C.A., Soontornniyomkij, V., Wang, G., Swerdlow, S.H., HIV-associated Waldeyer's ring lymphoid hyperplasias: Characterization of multinucleated giant cells and the role of Epstein-Barr virus (1999) Hum Pathol, 30, pp. 1383-1388
  • Yoshida, S., Golub, M.S., Gershwin, M.E., Keen, C.L., The influence of aluminum on resistance to Listeria monocytogenes in Swiss Webster mice (1989) Int Arch Allergy Appl Immunol, 89, pp. 404-409
  • Mannhalter, J.W., Neychev, H.O., Zlabinger, G.J., Ahmad, R., Eibl, M.M., Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxyde: Effect on antigen uptake and antigen presentation (1985) Clin Exp Immunol, 61, pp. 143-151
  • Gupta, R.K., Aluminum compounds as vaccine adjuvants (1998) Adv Drug Delivery Rev, 32, pp. 155-172

Citas:

---------- APA ----------
Lauricella, A.M., Garbossa, G. & Nesse, A. (2001) . Dissimilar behavior of lymph cells in response to the action of aluminum. In vitro and in vivo studies. International Immunopharmacology, 1(9-10), 1725-1732.
http://dx.doi.org/10.1016/S1567-5769(01)00082-0
---------- CHICAGO ----------
Lauricella, A.M., Garbossa, G., Nesse, A. "Dissimilar behavior of lymph cells in response to the action of aluminum. In vitro and in vivo studies" . International Immunopharmacology 1, no. 9-10 (2001) : 1725-1732.
http://dx.doi.org/10.1016/S1567-5769(01)00082-0
---------- MLA ----------
Lauricella, A.M., Garbossa, G., Nesse, A. "Dissimilar behavior of lymph cells in response to the action of aluminum. In vitro and in vivo studies" . International Immunopharmacology, vol. 1, no. 9-10, 2001, pp. 1725-1732.
http://dx.doi.org/10.1016/S1567-5769(01)00082-0
---------- VANCOUVER ----------
Lauricella, A.M., Garbossa, G., Nesse, A. Dissimilar behavior of lymph cells in response to the action of aluminum. In vitro and in vivo studies. Int. Immunopharmacol. 2001;1(9-10):1725-1732.
http://dx.doi.org/10.1016/S1567-5769(01)00082-0