Artículo

Mascanfroni, I.D.; Cerliani, J.P.; Dergan-Dylon, S.; Croci, D.O.; Ilarregui, J.M.; Rabinovich, G.A. "Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications" (2011) International Immunopharmacology. 11(7):833-841
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Abstract:

In spite of their central role in orchestrating immunity, dendritic cells (DCs) can also limit harmful reactions and promote immune tolerance by inducing T cell anergy or favoring the differentiation of T regulatory (Treg) cells. Several factors may influence the 'decision' of DCs to become immunogenic or tolerogenic including the nature of antigenic challenge, the engagement of selective pathogen recognition receptors (PRRs) and the balance of cytokines and growth factors. In addition, mounting evidence indicates a key role of endogenous lectins including C-type lectins, siglecs and galectins in shaping DC immunogenicity and tailoring adaptive immune responses, through recognition of specific 'glycan signatures' on invading pathogens or host cells. While galectins are in general secreted proteins that act in a paracrine or autocrine manner, all known siglecs and most C-type lectins are membrane-bound receptors that convey glycan-containing information into DC differentiation or maturation programs. Yet, some of the signaling pathways triggered by endogenous lectins converge in similar functional outcomes regardless of divergences in their structure, homology or glycan-binding specificity. To gain a more complete understanding on the role of protein-glycan interactions in DC biology, here we will integrate scattered information on these structurally-divergent but functionally-related lectins and their potential biomedical applications. © 2011 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications
Autor:Mascanfroni, I.D.; Cerliani, J.P.; Dergan-Dylon, S.; Croci, D.O.; Ilarregui, J.M.; Rabinovich, G.A.
Filiación:Laboratorio de Inmunopatología, Instituto de Biología Y Medicina Experimental, Consejo Nacional de Investigaciones Científicas Y Técnicas, C1428, Ciudad de Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, C1428, Ciudad de Buenos Aires, Argentina
Palabras clave:C-type lectins; Dendritic cells; Galectins; Lectins; Siglecs; cytokine; galectin; growth factor; lectin; adaptive immunity; antigen presenting cell; CD4+ CD25+ T lymphocyte; cell function; dendritic cell; gene expression; helper cell; human; immune deficiency; immune response; immunogenicity; immunological tolerance; immunosuppressive treatment; lymphocyte differentiation; medical technology; monocyte; nonhuman; phenotype; priority journal; protein expression; protein interaction; protein structure; regulatory T lymphocyte; review; signal transduction; T lymphocyte
Año:2011
Volumen:11
Número:7
Página de inicio:833
Página de fin:841
DOI: http://dx.doi.org/10.1016/j.intimp.2011.01.021
Título revista:International Immunopharmacology
Título revista abreviado:Int. Immunopharmacol.
ISSN:15675769
CODEN:IINMB
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15675769_v11_n7_p833_Mascanfroni

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Citas:

---------- APA ----------
Mascanfroni, I.D., Cerliani, J.P., Dergan-Dylon, S., Croci, D.O., Ilarregui, J.M. & Rabinovich, G.A. (2011) . Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications. International Immunopharmacology, 11(7), 833-841.
http://dx.doi.org/10.1016/j.intimp.2011.01.021
---------- CHICAGO ----------
Mascanfroni, I.D., Cerliani, J.P., Dergan-Dylon, S., Croci, D.O., Ilarregui, J.M., Rabinovich, G.A. "Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications" . International Immunopharmacology 11, no. 7 (2011) : 833-841.
http://dx.doi.org/10.1016/j.intimp.2011.01.021
---------- MLA ----------
Mascanfroni, I.D., Cerliani, J.P., Dergan-Dylon, S., Croci, D.O., Ilarregui, J.M., Rabinovich, G.A. "Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications" . International Immunopharmacology, vol. 11, no. 7, 2011, pp. 833-841.
http://dx.doi.org/10.1016/j.intimp.2011.01.021
---------- VANCOUVER ----------
Mascanfroni, I.D., Cerliani, J.P., Dergan-Dylon, S., Croci, D.O., Ilarregui, J.M., Rabinovich, G.A. Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications. Int. Immunopharmacol. 2011;11(7):833-841.
http://dx.doi.org/10.1016/j.intimp.2011.01.021