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Abstract:

Every year more than 2 million tons of citric acid (CA) are produced around the world for industrial uses. Although initially extracted from citrus, the low profitability of the process and the increasing demand soon stimulated the search for more efficient methods to produce CA. Currently, most world CA demand (99%) is satisfied by fermentations with microorganisms, especially filamentous fungi and yeasts. CA production with yeasts has certain advantages over molds (e.g. higher productivity and easier cultivation), which in the last two decades have triggered a clear increase in publications and patents devoted to the use of yeasts in this field. Yarrowia lipolytica has become a model yeast that proved to be successful in different production systems. Considering the current interest evidenced in the literature, the most significant information on CA production using Y. lipolytica is summarized. The relevance on CA yields of key factors such as strains, media formulation, environmental conditions and production regimes is thoroughly discussed, with particular focus on increasing CA productivity. Besides, the possibility of tuning the mentioned variables to reduce concomitant isocitric acid production-the biggest disadvantage of using yeasts-is analyzed. Available methods for CA purification/quantification are also discussed. © FEMS 2017.

Registro:

Documento: Artículo
Título:Yarrowia lipolytica: A model yeast for citric acid production
Autor:Cavallo, E.; Charreau, H.; Cerrutti, P.; Foresti, M.L.
Filiación:Grupo de Biotecnología y Biosíntesis, Instituto de Tecnología en Polímeros y Nanotecnología (ITPN-UBA-CONICET), Facultad de Ingeniería, Universidad de Buenos Aires, Las Heras 2214, Buenos Aires, CP 1127AAR, Argentina
Departamento de Ingeniería Química, Facultad de Ingeniería, Universidad de Buenos Aires, Pabellón de Industrias Ciudad UniversitariaCP 1428EHA, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
Departamento de Inteligencia Tecnológica, Clarke, Modet and Co, Lavalle 190, 3, Buenos Aires, Argentina
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Palabras clave:Citric acid; Industry; Production conditions; Yarrowia lipolytica; Yeast; citric acid; isocitric acid; carbon; citric acid; nitrogen; biosynthesis; carbon source; chemical industry; downstream processing; drug industry; environmental factor; fermentation; food industry; fruit; metabolic engineering; nonhuman; oxygen consumption; pH; purification; Short Survey; temperature; Yarrowia lipolytica; culture medium; fermentation; metabolism; Yarrowia; Carbon; Citric Acid; Culture Media; Fermentation; Nitrogen; Yarrowia
Año:2017
Volumen:17
Número:8
DOI: http://dx.doi.org/10.1093/femsyr/fox084
Título revista:FEMS Yeast Research
Título revista abreviado:FEMS Yeast Res.
ISSN:15671356
CODEN:FYREA
CAS:citric acid, 126-44-3, 5949-29-1, 77-92-9, 8002-14-0; isocitric acid, 320-77-4; carbon, 7440-44-0; nitrogen, 7727-37-9; Carbon; Citric Acid; Culture Media; Nitrogen
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15671356_v17_n8_p_Cavallo

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Citas:

---------- APA ----------
Cavallo, E., Charreau, H., Cerrutti, P. & Foresti, M.L. (2017) . Yarrowia lipolytica: A model yeast for citric acid production. FEMS Yeast Research, 17(8).
http://dx.doi.org/10.1093/femsyr/fox084
---------- CHICAGO ----------
Cavallo, E., Charreau, H., Cerrutti, P., Foresti, M.L. "Yarrowia lipolytica: A model yeast for citric acid production" . FEMS Yeast Research 17, no. 8 (2017).
http://dx.doi.org/10.1093/femsyr/fox084
---------- MLA ----------
Cavallo, E., Charreau, H., Cerrutti, P., Foresti, M.L. "Yarrowia lipolytica: A model yeast for citric acid production" . FEMS Yeast Research, vol. 17, no. 8, 2017.
http://dx.doi.org/10.1093/femsyr/fox084
---------- VANCOUVER ----------
Cavallo, E., Charreau, H., Cerrutti, P., Foresti, M.L. Yarrowia lipolytica: A model yeast for citric acid production. FEMS Yeast Res. 2017;17(8).
http://dx.doi.org/10.1093/femsyr/fox084