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Abstract:

The understanding of the processes occurring in Nature has been a continuing concern throughout the history of mankind. Intellectual tools employed towards this goal were specific for each period and have been largely based on the prevailing paradigms that reigned in the past. In this work we present evidence that supports the idea of viruses as key agents mediating natural processes linked to the evolution of organisms, particularly those involved in the flux of genes in the environment. This point of view tinges our perception of Nature and prompts us to include “viral” creativity and plasticity among the tools we employ to analyze those processes far beyond actual paradigms. Experimental data to support this proposal arose during the study of the interaction of the human pathogen, herpes simplex virus (HSV) with sulfated polysaccharides during multiplication of the virus in vitro. Sulfated polysaccharides are the main chemical structures found in carrageenans (CGNs) that are natural products obtained from seaweeds, which proved to be strong inhibitors for the virus. Here we describe the interaction between virus and CGNs as a suitable scenario for the emergence of viral variants which proved to be markedly attenuated for mice. A striking feature of these variants is that they showed changes at the level of conserved regions of the genome such as the DNA polymerase and thymidine kinase genes. In view of these findings, the importance of HSV evolution towards attenuated variants by the action of polysaccharides is also discussed. Attenuation may be considered part of a natural evolutionary process enabling the virus to contribute with valuable information for the host. © 2016

Registro:

Documento: Artículo
Título:Viruses: As mediators in “Élan vital” of the “creative” evolution
Autor:Artuso, M.C.; Roldán, J.S.; Scolaro, L.A.; Carlucci, M.J.
Filiación:Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica—IQUIBICEN (CONICET-UBA), Laboratorio de Virología, Ciudad Universitaria, Argentina
Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Virología, Ciudad Universitaria, Argentina
Palabras clave:Carrageenans; Evolution; Herpes simplex virus; Horizontal gene transfer; Sulfated polysaccharides; Viruses; aciclovir; carrageenan; DNA polymerase; foscarnet; heparin; natural product; polysaccharide sulfate; thymidine kinase; polysaccharide; sulfate; antiviral resistance; antiviral susceptibility; coevolution; DNA polymerase gene; DNA virus; evolution; gene mutation; gene structure; Herpes simplex virus; herpes virus infection; human; immune evasion; nonhuman; priority journal; red alga; Review; seaweed; thymidine kinase gene; virus; virus cell interaction; virus entry; virus envelope; virus gene; virus genome; virus isolation; virus replication; virus virulence; animal; horizontal gene transfer; life; molecular evolution; mouse; Simplexvirus; Animals; Evolution, Molecular; Gene Transfer, Horizontal; Life; Mice; Polysaccharides; Simplexvirus; Sulfates; Viruses
Año:2016
Volumen:46
Página de inicio:78
Página de fin:84
DOI: http://dx.doi.org/10.1016/j.meegid.2016.10.028
Título revista:Infection, Genetics and Evolution
Título revista abreviado:Infec. Genet. Evol.
ISSN:15671348
CODEN:IGENC
CAS:aciclovir, 59277-89-3; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; DNA polymerase, 37217-33-7; foscarnet, 4428-95-9; heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5; polysaccharide sulfate, 79933-28-1; thymidine kinase, 9002-06-6, 9086-73-1; sulfate, 14808-79-8; Polysaccharides; Sulfates
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15671348_v46_n_p78_Artuso

Referencias:

  • Abergel, C., Rudinger-Thirion, J., Giegé, R., Claverie, J.M., Virus-encoded aminoacyl-tRNA synthetases: structural and functional characterization of mimivirus TyrRS and MetRS (2007) J. Virol., 81 (22), pp. 12406-12417
  • Abroi, A., Gough, J., Are viruses a source of new protein folds for organisms?—virosphere structure space and evolution (2011) BioEssays, 33 (8), pp. 626-635
  • Andrei, G., Balzarini, J., Fiten, P., De Clercq, E., Opdenakker, G., Snoeck, R., Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin (2005) J. Virol., 79, pp. 9.5863-9.5869
  • Ankel, H., Westra, D.F., Welling-Wester, S., Lebon, P., Induction of interferon-alpha by glycoprotein d of herpes simplex virus: a possible role of chemokine receptors (1998) Virology, 251, pp. 317-326
  • Artuso, M.C., Role of Sulfated Polysaccharides and Herpes Simples Virus Type 1 Variants in Viral Pathogenicity (2013), Universidad de Buenos Aires (Thesis Doctoral); Artuso, M.C., Linero, F., Gazzaniga, S., Scolaro, L., Pujol, C.A., Wainstok, R., Carlucci, M.J., Altered expression of cytokines in mice infected intranasally with two syncytial variants of herpes simplex virus type 1 (2014) Microb. Pathog., 2014 (71-72), pp. 68-72
  • Aziz, R.K., Breitbart, M., Edwards, R.A., Transposases are the most abundant, most ubiquitous genes in nature (2010) Nucleic Acids Res., 38 (13), pp. 4207-4217
  • Batzer, M.A., Deininger, P.L., Alu repeats and human genomic diversity (2002) Nat. Rev. Genet., 3, pp. 370-380
  • Bergh, O., Borsheim, K.Y., Bratbak, G., Heldal, M., High abundance of viruse found in aquatic environments (1989) Nature, 340, pp. 467-468
  • Bergson, H., Creative Evolution (1998), Dover Publications (Translated by Arthur Mitchell); Bouarab, K., Potin, P., Correa, J., Kloareg, B., Sulfated oligosaccharides mediate the interaction between a marine red alga and its green algal pathogenic endophyte (1999) Plant Cell, 11, pp. 1635-1650
  • Bouarab, K., Adas, F., Gaquerel, E., Kloareg, B., Salaün, J.-P., Potin, P., The innate immunity of a marine red alga involves oxylipins from both the eicosanoid and octadecanoid pathways (2004) Plant Physiol., 135, pp. 1838-1848
  • Boyer, M., Madoui, M.A., Jiménez, G., La Scola, B., Raoult, D., Phylogenetic and phyletic studies of informational genes in genomes highlight existence of a 4 domain of life including gigant viruses (2011) PLoS One, 5 (12). , e15530
  • Briones, C., Domingo, E., Minority report: hidden memory genomes in HIV-1 quasispecies and possible clinical implications (2008) AIDS Rev., 10 (2), pp. 93-109
  • Carlucci, M.J., Scolaro, L.A., Damonte, E.B., Inhibitory action of natural carrageenans on herpes simplex virus infection of mouse astrocytes (1999) Chemotherapy, 45, pp. 429-436
  • Carlucci, M.J., Ciancia, M., Matulewicz, M.C., Cerezo, A.S., Damonte, E.B., Antiherpetic activity and mode of action of natural carrageenans of diverse structural types (1999) Antivir. Res., 43, pp. 93-102
  • Carlucci, M.J., Scolaro, L.A., Damonte, E.B., Herpes simplex virus type 1 variants arising after selection with antiviral carrageenan: lack of correlation between drug-susceptibility and syn phenotype (2002) J. Med. Virol., 68, pp. 82-91
  • Carlucci, M.J., Damonte, E.B., Scolaro, L.A., Virus driven evolution: a probable explanation for “Similia Similibus Curantur” philosophy (2011) Infect. Genet. Evol., 11, pp. 798-802
  • Carlucci, M.J., Mateu, C.G., Artuso, M.C., Scolaro, L.A., Polysaccharides from red algae: genesis of a renaissance (2012), In: The Complex World of Polysaccharides. Desiree Nedra Karunaratne. (Edit: InTech. Croacia); Cassaro, C.M., Dietrich, C.P., Distribution of sulfated mucopolysaccharides in invertebrates (1977) J. Biol. Chem., 252, pp. 2254-2261
  • Chao, L., Fitness of RNA virus decreased by Muller's ratchet (1990) Nature, 348 (6300), pp. 454-455
  • Chiang, H.Y., Cohen, G.H., Eisenberg, R.J., Identification of functional regions of herpes simplex virus glycoprotein gd by using linker-insertion mutagenesis (1994) J. Virol., 68, pp. 2529-2543
  • Clarke, D.K., Duarte, E.A., Elena, S.F., Moya, A., Domingo, E., Holland, J., The red queen reigns in the kingdom of RNA viruses (1994) Proc. Natl. Acad. Sci. U. S. A., 91 (11), pp. 4821-4824
  • Correa, J.A., Nielsen, R., Grund, D.W., Endophytic algae of Chondrus crispus Stackhouse. II. Acrochaete heteroclada sp. nov., Acrochaete operculata sp. nov., and Phaeophila dendroides (Crouan frat.) Batters (Chlorophyta) (1988) J. Phycol., 24, pp. 528-539
  • Cosse, A., Leblanc, C., Potin, P., Dynamic defense of marine macroalgae against pathogens: from early activated to gene-regulated responses (2007) Adv. Bot. Res., 46, pp. 221-266
  • Damonte, E.B., Matulewicz, M.C., Cerezo, A.S., Sulfated seaweed polysaccharides as antiviral agents (2004) Curr. Med. Chem., 11, pp. 2399-2419
  • Dietrich, C.P., Nader, H.B., Straus, A.H., Structural differences of heparan sulfates according to the tissue and species of origin (1983) Biochem. Biophys. Res. Commun., 111, pp. 865-871
  • Domingo, E., Paradoxical interplay of viral and cellular functions (2011) Viruses, 3, pp. 272-277
  • Domingo, E., Sheldon, J., Perales, C., Viral quasispecies evolution (2012) Microbiol. Mol. Biol. Rev., 76 (2), pp. 159-216
  • Drake, J.W., Holland, J.J., Mutation rates among RNA viruses (1999) Proc. Natl. Acad. Sci. U. S. A., 96, pp. 13910-13913
  • Duffy, S., Shackelton, L.A., Holmes, E.C., Rates of evolutionary change in viruses: patterns and determinants (2008) Nat. Rev. Genet., 9 (4), pp. 267-276
  • Eickbush, T.H., Repair by retrotransposition (2002) Nat. Genet., 31, pp. 126-127
  • Esko, J.D., Selleck, S.B., Order out of chaos: assembly of ligand binding sites in heparan sulfate (2002) Annu. Rev. Biochem., 71, pp. 435-471
  • Forterre, P., The origin of viruses and their possible roles in major evolutionary transitions (2006) Virus Res., 117, pp. 5-16
  • Forterre, P., Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: a hipótesis for the origin of cellular domain (2006) Proc. Natl. Acad. Sci. U. S. A., 103, pp. 3669-3674
  • Forterre, P., A new fusion hypothesis for the origin of Eukarya: better than previous ones, but probably also wrong (2011) Res. Microbiol., 162, pp. 77-91
  • Friedman, H.M., Wang, L., Panqburn, M.R., Lambris, J.D., Lubinski, J., Novel mechanism of antibody-independent complement neutralization of herpes simplex virus type 1 (2000) J. Immunol., 165 (8), pp. 4528-4536. , (15)
  • Gagneux, P., Varki, A., Evolutionary considerations in relating oligosaccharide diversity to biological function (1999) Glycobiology, 9, pp. 747-755
  • Goodier, J.L., Kazazian, H.H., Retrotransposons revisited: the restraint and rehabilitation of parasites (2008) Cell, 135, pp. 23-35
  • Hengel, H., Koszinowski, U.H., Conzelmann, K.K., Viruses know it all: new insights into INF networks (2005) Trends Immunol., 26 (7), pp. 396-401
  • Holland, J.J., de la Torre, J.C., Clarke, D.K., Duarte, E., Quantitation of relative fitness and great adaptability of clonal populations of RNA viruses (1991) J. Virol., 65 (6), pp. 2960-2967
  • Horie, M., Tomonaga, K., Non-retroviral fossils in vertebrate genomes (2011) Viruses, 3, pp. 1836-1848
  • Kauffman, S.A., Investigations (2000), Oxford University Press Oxford, UK; Kauffman, S.A., Question 1: origin of life and the living state (2007) Orig. Life Evol. Biosph., 37, pp. 315-322
  • Kauffman, S.A., Clayton, P., On emergence, agency, and organization (2006) Biol. Philos., 21, pp. 501-521
  • Knoll, A.H., The early evolution of eukaryotes: a geological perspective (1992) Science, 256, pp. 622-627
  • Koonin, E.V., Senkevich, T.G., Dolja, V.V., The ancient virus world and evolution of cells (2006) Biol. Direct, 1, p. 29
  • Lamb, D.C., Lei, L., Warrilow, A.G., Lepesheva, G.I., Mullins, J.G., Waterman, M.R., Kelly, S.L., The first virally encoded cytochrome p450 (2009) J. Virol., 83 (16), pp. 8266-8269
  • Larcher, C., Gasser, A., Hattmannstorfer, R., Obexer, P., Fürhapter, C., Frisch, P., Sepp, N., Interaction of HSV-1 infected peripheral blood mononuclear cells with cultured dermal microvascular endothelial cells: a potential model for the pathogenesis of HSV-1 induced erythema multiforme (2001) J. Invest. Dermatol., 116, pp. 150-156
  • Lindell, D., Sullivan, M.B., Johnson, Z.I., Tolonen, A.C., Rohwer, F., Chisholm, S.W., Transfer of photosynthesis genes to and from Prochlorococcus viruses (2004) Proc. Natl. Acad. Sci. U. S. A., 101 (30), pp. 11013-11018
  • Lynch, V.J., Leclerc, R.D., May, G., Wagner, G.P., Transposon-mediated rewiring of gene regulatory networks contributed to the evolution of pregnancy in mammals (2011) Nat. Genet., 43 (11), pp. 1154-1159
  • Martinez, M.A., Martrus, G., Capel, E., Parera, M., Franco, S., Nevot, M., Quasispecies dynamics of RNA viruses (2012) Viruses: Essential Agents of Life, pp. 21-42. , G. Witzany Springer Dordrecht Heidelberg, New York, London
  • Mateu, C., Polysaccharides and Herpes Simplex Virus Variants as Tools for the Viral Pathogeny Elucidation (2011), Universidad de Buenos Aires (Thesis Doctoral); Mateu, C., Perez Recalde, M., Artuso, M., Hermida, G., Linero, F.N., Scolaro, L.A., Damonte, E.B., Carlucci, M.J., Emergence of HSV-1 syncytial variants with altered virulence for mice after selection with a natural carrageenan (2011) J. Sex. Transm. Dis., 38 (6), pp. 548-554
  • Mateu, C., Artuso, M.C., Pujol, C.A., Linero, F., Scolaro, L.A., Carlucci, M.J., In vitro isolation of variant of herpes simplex virus attenuated with altered thymidine kinase and DNA polymerase genes using carrageenans as selection agents (2016) Symbiosis
  • McGeoch, D.J., Rixon, F.J., Davison, A.J., Topics in herpesvirus genomics and evolution (2006) Virus Res., 117 (1), pp. 90-104
  • Meckes, D.G., Wills, J.W., Structural rearrangement within an enveloped virus upon binding to the host cell (2008) J. Virol., 82 (21), pp. 10429-10435
  • Miller-Kittrell, M., Sparer, T.E., Feeling manipulated: cytomegalovirus immune manipulation (2009) Virol. J., 6, p. 4
  • Monier, A., Pagarete, A., de Vargas, C., Allen, M.J., Read, B., Claverie, J.M., Ogata, H., Horizontal gene transfer of an entire metabolic pathway between a eukaryotic alga and its DNA virus (2009) Genome Res., 19 (8), pp. 1441-1449
  • Neumann, J., Eis-Hübinger, A.M., Koch, N., Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion (2003) J. Immunol., 171, pp. 3075-3083
  • Niklas, K.J., The cell walls that bind the tree of life (2004) Bioscience, 54, pp. 831-841
  • Novak, N., Peng, W.M., Dancing with the enemy: the interplay of herpes simplex virus with dendritic cells (2005) Clin. Exp. Immunol., 142, pp. 405-410
  • Nozaki, H., Matsuzaki, M., Takahara, M., Misumi, O., Kuroiwa, H., Hasegawa, M., Shini, T., Kuroiwa, T., The phylogenetic position of red algae revealed by multiple nuclear genes from mitochondria-containing eukaryotes and an alternative hypothesis o the origin of plastids (2003) J. Mol. Evol., 56, pp. 485-497
  • O'Donnell, K.A., Burns, K.H., Mobilizing diversity: transposable element insertions in genetic variation and disease (2010) Mob. DNA, 1, p. 21
  • Ojosnegros, S., Perales, C., Mas, A., Domingo, E., Quasispecies as a matter of fact: viruses and beyond (2011) Virus Res., 162 (1-2), pp. 203-215
  • Paludan, S.R., Mogensen, S.C., Virus-cell interactions regulating induction of tumor necrosis factor alpha production in macrophages infected with herpes simplex virus (2001) J. Virol., 75, pp. 10170-10178
  • Pujol, C.A., Carlucci, M.J., Matulewicz, M.C., Damonte, E.B., Natural sulfated polysaccharides for the prevention and control of viral infections (2007) Editorial: Springer-Verlag. Alemania. Topics in Heterocyclic Chemistry. Bioactive Heterocycles V, p. 2007
  • Ryan, F., Virolution (2013), Harper Collins UK; Suttle, C.A., Marine viruses-major players in the global ecosystem (2007) Nat. Rev. Microbiol., 5, pp. 801-812
  • Svobodova, S., Bell, S., Crump, C., Analysis of the interaction between the essential herpes simples virus tegument proteins VP16 and VP1/2 (2011) J. Virol., pp. 473-483
  • Teng, Y.C., Chen, Y.T., Cheng, Y.Y., Hung, S.L., Requirements for the upregulation of interleukin-6 by herpes simplex virus-infected gingival fibroblasts (2005) Viral Immunol., 18, pp. 170-178
  • Vilarreal, L.P., Virus-host symbiosis mediated by persistence (2007) Symbiosis, 43, pp. 1-9
  • Villarreal, L.P., Viruses and the Evolution of Life (2005), American Society for Microbiology Press Washington, DC; Villarreal, L.P., From bacteria to belief: immunity and security (2008) Natural Security: a Darwinian Approach to a Dangerous World, pp. 25-41. , R.D. Sagarin T. Taylor University of California Press Berkeley, California
  • Villarreal, L.P., Origin of Group Identity. An Overview: Identity from Bacteria to Belief (2009), pp. 1-26. , Springer USA; Villarreal, L.P., Origin of Group Identity. Viruses, Addiction and Cooperation. Chapter 5. Animal Group Identity: From Slime to Worms, Emergence of the Brain (2009), pp. 165-253. , Springer NY; Villarreal, L.P., Viral ancestors of antiviral systems (2011) Viruses, 3, pp. 1933-1958
  • Wang, T., Zeng, J., Lowe, C.B., Sellers, R.G., Salama, S.R., Yang, M., Burgess, S.M., Haussler, D., Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53 (2007) Proc. Natl. Acad. Sci. U. S. A., 104 (47), pp. 18613-18618
  • Weber, M.J., Mammalian small nucleolar RNAs are mobile genetic elements (2006) PLoS Genet., 2, pp. 1984-1997
  • Whitley, R.J., Roizman, B., Herpes simplex virus infections (2001) Lancet, 357 (9267), pp. 1513-1518
  • Witzany, G., Natural genome-editing competences of viruses (2006) Acta Biotheor., 54 (4), pp. 235-253
  • Witzany, G., The viral origins of telomeres and telomerases and their important role in eukaryogenesis and genome maintenance (2008) Biosem, 2, pp. 191-206
  • Witzany, G., Noncoding RNAs: persistent viral agents as modular tools for cellular needs. Natural genetic engineering and natural genome editing (2009) Ann. N. Y. Acad. Sci., 1178, pp. 26-244
  • Witzany, G., Natural Genetic Engineering and Natural Genome Editing (2009), Wiley Blackwell Boston; Witzany, G., Biocommunication and Natural Genome Editing (2010), Springer Dordrecht; Witzany, G., Natural genome editing from a biocommunicative perspective (2011) Biosemiotics, 4 (3), pp. 349-368
  • Witzany, G., The agents of natural genome editing (2011) J. Mol. Cell Biol., 3 (3), pp. 181-189
  • Witzany, G., From molecular entities to competent agents: viral infection-derived consortia act as natural genetic engineers (2012) Viruses: Essential Agents of Life, , Springer
  • Yermak, I.M., Khotimchenko, Y.S., Fingerman, M., Nagabhushanam, R., Chemical Properties, Biological Activities and Applications of Carrageenan from Red Algae (2003) Recent Advances in Marine Biotechnology, 3, pp. 207-210. , Science Publishers Inc. New York

Citas:

---------- APA ----------
Artuso, M.C., Roldán, J.S., Scolaro, L.A. & Carlucci, M.J. (2016) . Viruses: As mediators in “Élan vital” of the “creative” evolution. Infection, Genetics and Evolution, 46, 78-84.
http://dx.doi.org/10.1016/j.meegid.2016.10.028
---------- CHICAGO ----------
Artuso, M.C., Roldán, J.S., Scolaro, L.A., Carlucci, M.J. "Viruses: As mediators in “Élan vital” of the “creative” evolution" . Infection, Genetics and Evolution 46 (2016) : 78-84.
http://dx.doi.org/10.1016/j.meegid.2016.10.028
---------- MLA ----------
Artuso, M.C., Roldán, J.S., Scolaro, L.A., Carlucci, M.J. "Viruses: As mediators in “Élan vital” of the “creative” evolution" . Infection, Genetics and Evolution, vol. 46, 2016, pp. 78-84.
http://dx.doi.org/10.1016/j.meegid.2016.10.028
---------- VANCOUVER ----------
Artuso, M.C., Roldán, J.S., Scolaro, L.A., Carlucci, M.J. Viruses: As mediators in “Élan vital” of the “creative” evolution. Infec. Genet. Evol. 2016;46:78-84.
http://dx.doi.org/10.1016/j.meegid.2016.10.028