Artículo

Zingales, B.; Miles, M.A.; Campbell, D.A.; Tibayrenc, M.; Macedo, A.M.; Teixeira, M.M.G.; Schijman, A.G.; Llewellyn, M.S.; Lages-Silva, E.; Machado, C.R.; Andrade, S.G.; Sturm, N.R. "The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications" (2012) Infection, Genetics and Evolution. 12(2):240-253
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Abstract:

The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and the understanding of the population structure of this parasite is critical because of the links to transmission cycles and disease. At present, T. cruzi is partitioned into six discrete typing units (DTUs), TcI-TcVI. Here we focus on the current status of taxonomy-related areas such as population structure, phylogeographical and eco-epidemiological features, and the correlation of DTU with natural and experimental infection. We also summarize methods for DTU genotyping, available for widespread use in endemic areas. For the immediate future multilocus sequence typing is likely to be the gold standard for population studies. We conclude that greater advances in our knowledge on pathogenic and epidemiological features of these parasites are expected in the coming decade through the comparative analysis of the genomes from isolates of various DTUs. © 2012 Elsevier B.V.

Registro:

Documento: Artículo
Título:The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications
Autor:Zingales, B.; Miles, M.A.; Campbell, D.A.; Tibayrenc, M.; Macedo, A.M.; Teixeira, M.M.G.; Schijman, A.G.; Llewellyn, M.S.; Lages-Silva, E.; Machado, C.R.; Andrade, S.G.; Sturm, N.R.
Filiación:Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Avenida Professor Lineu Prestes 748, 05508-000 São Paulo, SP, Brazil
The London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095-7065, United States
Maladies Infectieuses et Vecteurs Ecologie, Génétique, Evolution et Contrôle, MIVEGEC/IDVEGEC, UM1-CNRS 5290-IRD 224, IRD Center, BP 64501, 34394 Montpellier Cedex 5, France
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 486, 30161-970 Belo Horizonte, MG, Brazil
Departamento de Parasitologia, Instituto de Biociências, Universidade de São Paulo, Avenida Professor Lineu Prestes 1374, 05508-000 São Paulo, SP, Brazil
Laboratorio de Biología Molecular de la Enfermedad de Chagas, INGEBI-CONICET, Vuelto Obligado 2490, Buenos Aires 1428, Argentina
Departamento de Ciências Biológicas, Universidade Federal do Triângulo Mineiro, Rua Frei Paulino 30, Uberaba, MG, Brazil
Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão 121, 40295-001 Salvador, Brazil
Palabras clave:Discrete typing unit; Genotyping; Hybridization; Pathology; Phylogeography; Trypanosoma cruzi strains; ribosome DNA; clinical feature; disease transmission; gene frequency; genetic variability; genome analysis; genotype; geographic distribution; heterozygosity; human; mitochondrial genome; multilocus sequence typing; nonhuman; phylogeography; population research; population structure; priority journal; review; single nucleotide polymorphism; taxonomy; Trypanosoma cruzi; Animals; Chagas Disease; Chiroptera; Evolution, Molecular; Genetic Variation; Genome, Protozoan; Genomics; Humans; Multilocus Sequence Typing; Phylogeography; Terminology as Topic; Trypanosoma cruzi; Mammalia; Protozoa; Trypanosoma cruzi
Año:2012
Volumen:12
Número:2
Página de inicio:240
Página de fin:253
DOI: http://dx.doi.org/10.1016/j.meegid.2011.12.009
Título revista:Infection, Genetics and Evolution
Título revista abreviado:Infec. Genet. Evol.
ISSN:15671348
CODEN:IGENC
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15671348_v12_n2_p240_Zingales

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Citas:

---------- APA ----------
Zingales, B., Miles, M.A., Campbell, D.A., Tibayrenc, M., Macedo, A.M., Teixeira, M.M.G., Schijman, A.G.,..., Sturm, N.R. (2012) . The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications. Infection, Genetics and Evolution, 12(2), 240-253.
http://dx.doi.org/10.1016/j.meegid.2011.12.009
---------- CHICAGO ----------
Zingales, B., Miles, M.A., Campbell, D.A., Tibayrenc, M., Macedo, A.M., Teixeira, M.M.G., et al. "The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications" . Infection, Genetics and Evolution 12, no. 2 (2012) : 240-253.
http://dx.doi.org/10.1016/j.meegid.2011.12.009
---------- MLA ----------
Zingales, B., Miles, M.A., Campbell, D.A., Tibayrenc, M., Macedo, A.M., Teixeira, M.M.G., et al. "The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications" . Infection, Genetics and Evolution, vol. 12, no. 2, 2012, pp. 240-253.
http://dx.doi.org/10.1016/j.meegid.2011.12.009
---------- VANCOUVER ----------
Zingales, B., Miles, M.A., Campbell, D.A., Tibayrenc, M., Macedo, A.M., Teixeira, M.M.G., et al. The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications. Infec. Genet. Evol. 2012;12(2):240-253.
http://dx.doi.org/10.1016/j.meegid.2011.12.009