Artículo

Compagno, D.; Jaworski, F.M.; Gentilini, L.; Contrufo, G.; Pérez, I.G.; Elola, M.T.; Pregi, N.; Rabinovich, G.A.; Laderach, D.J. "Galectins: Major signaling modulators inside and outside the cell" (2014) Current Molecular Medicine. 14(5):630-651
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Abstract:

Galectins control cell behavior by acting on different signaling pathways. Most of the biological activities ascribed to these molecules rely upon recognition of extracellular glycoconjugates and establishment of multivalente interactions, which trigger adaptive biological responses. However, galectins are also detected within the cell in different compartments, where their regulatory functions still remain poorly understood. A deeper understanding of the entire galectin signalosome and its impact in cell behavior is therefore essential in order to delineate new strategies to specifically manipulate both galectin expression and function. This review summarizes our current knowledge of the signaling pathways activated by galectins, their glycan dependence and the cellular compartment where they become activated and are biologically relevant. © 2014 Bentham Science Publishers.

Registro:

Documento: Artículo
Título:Galectins: Major signaling modulators inside and outside the cell
Autor:Compagno, D.; Jaworski, F.M.; Gentilini, L.; Contrufo, G.; Pérez, I.G.; Elola, M.T.; Pregi, N.; Rabinovich, G.A.; Laderach, D.J.
Filiación:Laboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica, Universidad de Buenos Aires, Argentina
Laboratorio de Biologia Molecular, Regulacion de la Expresión Génica y Ciclo Celular, Departamento de Química Biológica, Universidad de Buenos Aires, Argentina
Instituto de Química y Fisicoquímica Biológicas (IQUIFIB, CONICET), Universidad de Buenos Aires, Argentina
Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina
Palabras clave:Apoptosis; Cell adherence; Galectins; Immune regulation; Oncogenesis; Signaling pathways; CD45 antigen; CD98 antigen; galectin; glycoconjugate; immunoglobulin enhancer binding protein; protein bcl 2; Ras protein; Smad3 protein; stress activated protein kinase; galectin; apoptosis; cell migration; cell proliferation; downregulation; gene control; human; nuclear localization signal; protein expression; protein localization; protein phosphorylation; protein processing; review; signal transduction; spliceosome; T lymphocyte; tandem repeat; animal; carcinogenesis; cell adhesion; metabolism; physiology; Animals; Carcinogenesis; Cell Adhesion; Galectins; Humans; Signal Transduction
Año:2014
Volumen:14
Número:5
Página de inicio:630
Página de fin:651
DOI: http://dx.doi.org/10.2174/1566524014666140603101953
Título revista:Current Molecular Medicine
Título revista abreviado:Curr. Mol. Med.
ISSN:15665240
CODEN:CMMUB
CAS:protein bcl 2, 219306-68-0; Smad3 protein, 237417-78-6, 237417-96-8, 237418-00-7; stress activated protein kinase, 155215-87-5; Galectins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15665240_v14_n5_p630_Compagno

Referencias:

  • Vasta, G.R., Galectins as pattern recognition receptors: Structure, function, and evolution (2012) Adv Exp Med Biol, 946, pp. 21-36
  • Rabinovich, G.A., Toscano, M.A., Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation (2009) Nat Rev Immunol, 9, pp. 338-352
  • Hirabayashi, J., Kasai, K., The family of metazoan metalindependent beta-galactoside-binding lectins: Structure, function and molecular evolution (1993) Glycobiology, 3, pp. 297-304
  • Barondes, S.H., Castronovo, V., Cooper, D.N., Galectins: A family of animal beta-galactoside-binding lectins (1994) Cell, 76, pp. 597-598
  • Leffler, H., Carlsson, S., Hedlund, M., Qian, Y., Poirier, F., Introduction to galectins (2004) Glycoconj J, 19, pp. 433-440
  • Rabinovich, G.A., Baum, L.G., Tinari, N., Galectins and their ligands: Amplifiers, silencers or tuners of the inflammatory response? (2002) Trends Immunol, 23, pp. 313-320
  • Rabinovich, G.A., Croci, D.O., Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer (2012) Immunity, 36, pp. 322-335
  • Gabius, H.J., Wu, A.M., The emerging functionality of endogenous lectins: A primer to the concept and a case study on galectins including medical implications (2006) Chang Gung Med J, 29, pp. 37-62
  • Laderach, D.J., Compagno, D., Toscano, M.A., Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings (2010) IUBMB Life, 62, pp. 1-13
  • Gabius, H.J., Andre, S., Jimenez-Barbero, J., Romero, A., Solis, D., From lectin structure to functional glycomics: Principles of the sugar code (2011) Trends Biochem Sci, 36, pp. 298-313
  • Agrwal, N., Wang, J.L., Voss, P.G., Carbohydrate-binding protein 35. Levels of transcription and mRNA accumulation in quiescent and proliferating cells (1989) J Biol Chem, 264, pp. 17236-17242
  • Openo, K.P., Kadrofske, M.M., Patterson, R.J., Wang, J.L., Galectin- 3 expression and subcellular localization in senescent human fibroblasts (2000) Exp Cell Res, 255, pp. 278-290
  • Hamann, K.K., Cowles, E.A., Wang, J.L., Anderson, R.L., Expression of carbohydrate binding protein 35 in human fibroblasts: Variations in the levels of mRNA, protein, and isoelectric species as a function of replicative competence (1991) Exp Cell Res, 196, pp. 82-91
  • Cho, M., Cummings, R.D., Galectin-1, a beta-galactosidebinding lectin in Chinese hamster ovary cells. I. Physical and chemical characterization (1995) J Biol Chem, 270, pp. 5198-5206
  • Leppanen, A., Stowell, S., Blixt, O., Cummings, R.D., Dimeric galectin-1 binds with high affinity to alpha2,3-sialylated and non-sialylated terminal N-acetyllactosamine units on surfacebound extended glycans (2005) J Biol Chem, 280, pp. 5549-5562
  • Morris, S., Ahmad, N., Andre, S., Quaternary solution structures of galectins-1, -3, and -7 (2004) Glycobiology, 14, pp. 293-300
  • Ahmad, N., Gabius, H.J., Andre, S., Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes (2004) J Biol Chem, 279, pp. 10841-10847
  • Davidson, P.J., Davis, M.J., Patterson, R.J., Ripoche, M.A., Poirier, F., Wang, J.L., Shuttling of galectin-3 between the nucleus and cytoplasm (2002) Glycobiology, 12, pp. 329-337
  • Davidson, P.J., Li, S.Y., Lohse, A.G., Transport of galectin-3 between the nucleus and cytoplasm. I. Conditions and signals for nuclear import (2006) Glycobiology, 16, pp. 602-611
  • Nakahara, S., Oka, N., Wang, Y., Hogan, V., Inohara, H., Raz, A., Characterization of the nuclear import pathways of galectin- 3 (2006) Cancer Res, 66, pp. 9995-10006
  • Paces-Fessy, M., Boucher, D., Petit, E., Paute-Briand, S., Blanchet-Tournier, M.F., The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins (2004) Biochem J, 378, pp. 353-362
  • Hughes, R.C., Secretion of the galectin family of mammalian carbohydrate-binding proteins (1999) Biochim Biophys Acta, 1473, pp. 172-185
  • Cowles, E.A., Agrwal, N., Anderson, R.L., Wang, J.L., Carbohydrate-binding protein 35. Isoelectric points of the polypeptide and a phosphorylated derivative (1990) J Biol Chem, 265, pp. 17706-17712
  • Huflejt, M.E., Turck, C.W., Lindstedt, R., Barondes, S.H., Leffler, H., L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I (1993) J Biol Chem, 268, pp. 26712-26718
  • Mazurek, N., Conklin, J., Byrd, J.C., Raz, A., Bresalier, R.S., Phosphorylation of the beta-galactoside-binding protein galectin-3 modulates binding to its ligands (2000) J Biol Chem, 275, pp. 36311-36315
  • Yoshii, T., Fukumori, T., Honjo, Y., Inohara, H., Kim, H.R., Raz, A., Galectin-3 phosphorylation is required for its anti-apoptotic function and cell cycle arrest (2002) J Biol Chem, 277, pp. 6852-6857
  • Frigeri, L.G., Robertson, M.W., Liu, F.T., Expression of biologically active recombinant rat IgE-binding protein in Escherichia coli (1990) J Biol Chem, 265, pp. 20763-20769
  • Gohler, A., Buchner, C., Andre, S., Soren, D., Kaltner, H., Gabius, H.J., Analysis of homodimeric avian and human galectins by two methods based on fluorescence spectroscopy: Different structural alterations upon oxidation and ligand binding (2012) Biochimie, 94, pp. 2649-2655
  • Herrmann, J., Turck, C.W., Atchison, R.E., Primary structure of the soluble lactose binding lectin L-29 from rat and dog and interaction of its non-collagenous proline-, glycine-, tyrosine-rich sequence with bacterial and tissue collagenase (1993) J Biol Chem, 268, pp. 26704-26711
  • Vyakarnam, A., Lenneman, A.J., Lakkides, K.M., Patterson, R.J., Wang, J.L., A comparative nuclear localization study of galectin-1 with other splicing components (1998) Exp Cell Res, 242, pp. 419-428
  • Gaudin, J.C., Mehul, B., Hughes, R.C., Nuclear localisation of wild type and mutant galectin-3 in transfected cells (2000) Biol Cell, 92, pp. 49-58
  • Sato, S., Burdett, I., Hughes, R.C., Secretion of the baby hamster kidney 30-kDa galactose-binding lectin from polarized and nonpolarized cells: A pathway independent of the endoplasmic reticulum-Golgi complex (1993) Exp Cell Res, 207, pp. 8-18
  • Amano, M., Eriksson, H., Manning, J.C., Tumour suppressor p16(INK4a) - anoikis-favouring decrease in N/Oglycan/ cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model (2012) Febs J, 279, pp. 4062-4080
  • Paron, I., Scaloni, A., Pines, A., Nuclear localization of Galectin-3 in transformed thyroid cells: A role in transcriptional regulation (2003) Biochem Biophys Res Commun, 302, pp. 545-553
  • Yu, X., Siegel, R., Roeder, R.G., Interaction of the B cell-specific transcriptional coactivator OCA-B and galectin-1 and a possible role in regulating BCR-mediated B cell proliferation (2006) J Biol Chem, 281, pp. 15505-15516
  • Felin, M., Doyennette-Moyne, M.A., Hadj-Sahraoui, Y., Aubery, M., Hubert, J., Seve, A.P., Identification of two nuclear Nacetylglucosamine- binding proteins (1994) J Cell Biochem, 56, pp. 527-535
  • Lin, H.M., Pestell, R.G., Raz, A., Kim, H.R., Galectin-3 enhances cyclin D(1) promoter activity through SP1 and a cAMPresponsive element in human breast epithelial cells (2002) Oncogene, 21, pp. 8001-8010
  • Vyakarnam, A., Dagher, S.F., Wang, J.L., Patterson, R.J., Evidence for a role for galectin-1 in pre-mRNA splicing (1997) Mol Cell Biol, 17, pp. 4730-4737
  • Park, J.W., Voss, P.G., Grabski, S., Wang, J.L., Patterson, R.J., Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein (2001) Nucleic Acids Res, 29, pp. 3595-3602
  • Fakan, S., Leser, G., Martin, T.E., Ultrastructural distribution of nuclear ribonucleoproteins as visualized by immunocytochemistry on thin sections (1984) J Cell Biol, 98, pp. 358-363
  • Charroux, B., Pellizzoni, L., Perkinson, R.A., Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli (2000) J Cell Biol, 148, pp. 1177-1186
  • Mourelatos, Z., Dostie, J., Paushkin, S., miRNPs: A novel class of ribonucleoproteins containing numerous microRNAs (2002) Genes Dev, 16, pp. 720-728
  • Paushkin, S., Gubitz, A.K., Massenet, S., Dreyfuss, G., The SMN complex, an assemblyosome of ribonucleoproteins (2002) Curr Opin Cell Biol, 14, pp. 305-312
  • Fischer, U., Liu, Q., Dreyfuss, G., The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis (1997) Cell, 90, pp. 1023-1029
  • Dagher, S.F., Wang, J.L., Patterson, R.J., Identification of galectin- 3 as a factor in pre-mRNA splicing (1995) Proc Natl Acad Sci U S A, 92, pp. 1213-1217
  • Laing, J.G., Wang, J.L., Identification of carbohydrate binding protein 35 in heterogeneous nuclear ribonucleoprotein complex (1988) Biochemistry, 27, pp. 5329-5334
  • Wang, L., Inohara, H., Pienta, K.J., Raz, A., Galectin-3 is a nuclear matrix protein which binds RNA (1995) Biochem Biophys Res Commun, 217, pp. 292-303
  • Wang, W., Park, J.W., Wang, J.L., Patterson, R.J., Immunoprecipitation of spliceosomal RNAs by antisera to galectin-1 and galectin-3 (2006) Nucleic Acids Res, 34, pp. 5166-5174
  • Voss, P.G., Gray, R.M., Dickey, S.W., Dissociation of the carbohydrate-binding and splicing activities of galectin-1 (2008) Arch Biochem Biophys, 478, pp. 18-25
  • Haudek, K.C., Voss, P.G., Locascio, L.E., Wang, J.L., Patterson, R.J., A mechanism for incorporation of galectin-3 into the spliceosome through its association with U1 snRNP (2009) Biochemistry, 48, pp. 7705-7712
  • Demers, M., Rose, A.A., Grosset, A.A., Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells (2010) Am J Pathol, 176, pp. 3023-3031
  • Inagaki, Y., Higashi, K., Kushida, M., Hepatocyte growth factor suppresses profibrogenic signal transduction via nuclear export of Smad3 with galectin-7 (2008) Gastroenterology, 134, pp. 1180-1190
  • Matsuura, A., Tsukada, J., Mizobe, T., Intracellular galectin-9 activates inflammatory cytokines in monocytes (2009) Genes Cells, 14, pp. 511-521
  • Zhu, C., Anderson, A.C., Schubart, A., The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity (2005) Nat Immunol, 6, pp. 1245-1252
  • Oomizu, S., Arikawa, T., Niki, T., Cell surface galectin-9 expressing th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion (2012) PLoS One, 7, pp. e48574
  • Delgado, V.M., Nugnes, L.G., Colombo, L.L., Modulation of endothelial cell migration and angiogenesis: A novel function for the tandem-repeat lectin galectin-8 (2011) Faseb J, 25, pp. 242-254
  • Dvorak, A.M., Ackerman, S.J., Furitsu, T., Estrella, P., Letourneau, L., Ishizaka, T., Mature eosinophils stimulated to develop in human-cord blood mononuclear cell cultures supplemented with recombinant human interleukin-5. II. Vesicular transport of specific granule matrix peroxidase, a mechanism for effecting piecemeal degranulation (1992) Am J Pathol, 140, pp. 795-807
  • Dunphy, J.L., Balic, A., Barcham, G.J., Horvath, A.J., Nash, A.D., Meeusen, E.N., Isolation and characterization of a novel inducible mammalian galectin (2000) J Biol Chem, 275, pp. 32106-32113
  • Hotta, K., Funahashi, T., Matsukawa, Y., Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity (2001) J Biol Chem, 276, pp. 34089-34097
  • Dunphy, J.L., Barcham, G.J., Bischof, R.J., Young, A.R., Nash, A., Meeusen, E.N., Isolation and characterization of a novel eosinophil-specific galectin released into the lungs in response to allergen challenge (2002) J Biol Chem, 277, pp. 14916-14924
  • Dvorankova, B., Lacina, L., Smetana Jr., K., Human galectin-2: Nuclear presence in vitro and its modulation by quiescence/stress factors (2008) Histol Histopathol, 23, pp. 167-178
  • Saussez, S., Decaestecker, C., Lorfevre, F., Increased expression and altered intracellular distribution of adhesion/growth-regulatory lectins galectins-1 and -7 during tumour progression in hypopharyngeal and laryngeal squamous cell carcinomas (2008) Histopathology, 52, pp. 483-493
  • Yu, F., Finley Jr., R.L., Raz, A., Kim, H.R., Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin- 3 translocation (2002) J Biol Chem, 277, pp. 15819-15827
  • Kim, D.W., Kim, K.H., Yoo, B.C., Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells (2008) Cancer Sci, 99, pp. 1884-1891
  • Yang, R.Y., Hsu, D.K., Liu, F.T., Expression of galectin-3 modulates T-cell growth and apoptosis (1996) Proc Natl Acad Sci U S A, 93, pp. 6737-6742
  • Akahani, S., Nangia-Makker, P., Inohara, H., Kim, H.R., Raz, A., Galectin-3: A novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family (1997) Cancer Res, 57, pp. 5272-5276
  • Cheng, Y.L., Huang, W.C., Chen, C.L., Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli (2011) Biochem Biophys Res Commun, 412, pp. 334-340
  • Villeneuve, C., Baricault, L., Canelle, L., Mitochondrial proteomic approach reveals galectin-7 as a novel BCL-2 binding protein in human cells (2011) Mol Biol Cell, 22, pp. 999-1013
  • Fuertes, M.B., Molinero, L.L., Toscano, M.A., Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase (2004) Mol Cell Biochem, 267, pp. 177-185
  • Ilarregui, J.M., Croci, D.O., Bianco, G.A., Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1- driven immunoregulatory circuit involving interleukin 27 and interleukin 10 (2009) Nat Immunol, 10, pp. 981-991
  • Toscano, M.A., Campagna, L., Molinero, L.L., Nuclear factor (NF)-kappaB controls expression of the immunoregulatory glycan-binding protein galectin-1 (2011) Mol Immunol, 48, pp. 1940-1949
  • Liu, S.D., Tomassian, T., Bruhn, K.W., Miller, J.F., Poirier, F., Miceli, M.C., Galectin-1 tunes TCR binding and signal transduction to regulate CD8 burst size (2009) J Immunol, 182, pp. 5283-5295
  • Toscano, M.A., Bianco, G.A., Ilarregui, J.M., Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death (2007) Nat Immunol, 8, pp. 825-834
  • Espeli, M., Mancini, S.J., Breton, C., Poirier, F., Schiff, C., Impaired B cell development at the pre-BII cell stage in galectin-1 deficient mice due to inefficient pre-BII-stromal cell interactions (2009) Blood, 113, pp. 5878-5886
  • Zuniga, E., Rabinovich, G.A., Iglesias, M.M., Gruppi, A., Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis (2001) J Leukoc Biol, 70, pp. 73-79
  • Tsai, C.M., Guan, C.H., Hsieh, H.W., Galectin-1 and galectin- 8 have redundant roles in promoting plasma cell formation (2011) J Immunol, 187, pp. 1643-1652
  • Tsai, C.M., Chiu, Y.K., Hsu, T.L., Lin, I.Y., Hsieh, S.L., Lin, K.I., Galectin- 1 promotes immunoglobulin production during plasma cell differentiation (2008) J Immunol, 181, pp. 4570-4579
  • Tabrizi, S.J., Niiro, H., Masui, M., T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins (2009) J Immunol, 182, pp. 1490-1499
  • Starossom, S.C., Mascanfroni, I.D., Imitola, J., Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration (2012) Immunity, 37, pp. 249-263
  • Wang, Y., Balan, V., Kho, D., Hogan, V., Nangia-Makker, P., Raz, A., Galectin-3 regulates p21 stability in human prostate cancer cells (2012) Oncogene, 32, pp. 5058-5065
  • Yamazaki, K., Kawai, A., Kawaguchi, M., Simultaneous induction of galectin-3 phosphorylated on tyrosine residue, p21(WAF1/Cip1/Sdi1), and the proliferating cell nuclear antigen at a distinctive period of repair of hepatocytes injured by CCl4 (2001) Biochem Biophys Res Commun, 280, pp. 1077-1084
  • Nakahara, S., Oka, N., Raz, A., On the role of galectin-3 in cancer apoptosis (2005) Apoptosis, 10, pp. 267-275
  • Saegusa, J., Hsu, D.K., Liu, W., Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation (2008) J Invest Dermatol, 128, pp. 2403-2411
  • Califice, S., Castronovo, V., Bracke, M., van den Brule, F., Dual activities of galectin-3 in human prostate cancer: Tumor suppression of nuclear galectin-3 vs tumor promotion of cytoplasmic galectin-3 (2004) Oncogene, 23, pp. 7527-7536
  • Brand, C., Oliveira, F.L., Ricon, L., The bone marrow compartment is modified in the absence of galectin-3 (2011) Cell Tissue Res, 346, pp. 427-437
  • Hsu, D.K., Yang, R.Y., Pan, Z., Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses (2000) Am J Pathol, 156, pp. 1073-1083
  • Mackinnon, A.C., Farnworth, S.L., Hodkinson, P.S., Regulation of alternative macrophage activation by galectin- 3 (2008) J Immunol, 180, pp. 2650-2658
  • Acosta-Rodriguez, E.V., Montes, C.L., Motran, C.C., Galectin-3 mediates IL-4-induced survival and differentiation of B cells: Functional cross-talk and implications during Trypanosoma cruzi infection (2004) J Immunol, 172, pp. 493-502
  • Oliveira, F.L., Brand, C., Paula, A.A., Lack of galectin-3 disturbs mesenteric lymph node homeostasis and B cell niches in the course of Schistosoma mansoni infection (2011) PLoS One, 6, pp. e19216
  • Menon, R.P., Strom, M., Hughes, R.C., Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner (2000) FEBS Lett, 470, pp. 227-231
  • Bawumia, S., Barboni, E.A., Menon, R.P., Hughes, R.C., Specificity of interactions of galectin-3 with Chrp, a cysteine- and histidine-rich cytoplasmic protein (2003) Biochimie, 85, pp. 189-194
  • Goletz, S., Hanisch, F.G., Karsten, U., Novel alphaGalNAc containing glycans on cytokeratins are recognized invitro by galectins with type II carbohydrate recognition domains (1997) J Cell Sci, 110 (Pt 14), pp. 1585-1596
  • Paz, A., Haklai, R., Elad-Sfadia, G., Ballan, E., Kloog, Y., Galectin- 1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation (2001) Oncogene, 20, pp. 7486-7493
  • Rotblat, B., Belanis, L., Liang, H., H-Ras nanocluster stability regulates the magnitude of MAPK signal output (2004) PLoS One, 5, pp. e11991
  • Belanis, L., Plowman, S.J., Rotblat, B., Hancock, J.F., Kloog, Y., Galectin-1 is a novel structural component and a major regulator of h-ras nanoclusters (2008) Mol Biol Cell, 19, pp. 1404-1414
  • Elad-Sfadia, G., Haklai, R., Ballan, E., Gabius, H.J., Kloog, Y., Galectin-1 augments Ras activation and diverts Ras signals to Raf-1 at the expense of phosphoinositide 3-kinase (2002) J Biol Chem, 277, pp. 37169-37175
  • Vernitsky, H., Rechavi, O., Rainy, N., Ras oncoproteins transfer from melanoma cells to T cells and modulate their effector functions (2012) J Immunol, 189, pp. 4361-4370
  • Shalom-Feuerstein, R., Plowman, S.J., Rotblat, B., K-ras nanoclustering is subverted by overexpression of the scaffold protein galectin-3 (2008) Cancer Res, 68, pp. 6608-6616
  • Song, S., Mazurek, N., Liu, C., Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity (2009) Cancer Res, 69, pp. 1343-1349
  • Song, S., Ji, B., Ramachandran, V., Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling (2012) PLoS One, 7, pp. e42699
  • Levy, R., Grafi-Cohen, M., Kraiem, Z., Kloog, Y., Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas (2010) Mol Cancer Ther, 9, pp. 2208-2219
  • Koch, A., Poirier, F., Jacob, R., Delacour, D., Galectin-3, a novel centrosome-associated protein, required for epithelial morphogenesis (2010) Mol Biol Cell, 21, pp. 219-231
  • Chiu, M.G., Johnson, T.M., Woolf, A.S., Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney disease (2006) Am J Pathol, 169, pp. 1925-1938
  • Hsu, D.K., Chernyavsky, A.I., Chen, H.Y., Yu, L., Grando, S.A., Liu, F.T., Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells (2009) J Invest Dermatol, 129, pp. 573-583
  • Chen, H.Y., Fermin, A., Vardhana, S., Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse (2009) Proc Natl Acad Sci U S A, 106, pp. 14496-14501
  • Granovsky, M., Fata, J., Pawling, J., Muller, W.J., Khokha, R., Dennis, J.W., Suppression of tumor growth and metastasis in Mgat5-deficient mice (2000) Nat Med, 6, pp. 306-312
  • Dube, D.H., Bertozzi, C.R., Glycans in cancer and inflammation-- potential for therapeutics and diagnostics (2005) Nat Rev Drug Discov, 4, pp. 477-488
  • Fajka-Boja, R., Blasko, A., Kovacs-Solyom, F., Szebeni, G.J., Toth, G.K., Monostori, E., Co-localization of galectin-1 with GM1 ganglioside in the course of its clathrin- and raft-dependent endocytosis (2008) Cell Mol Life Sci, 65, pp. 2586-2593
  • Tanikawa, R., Tanikawa, T., Okada, Y., Interaction of galectin-9 with lipid rafts induces osteoblast proliferation through the c-Src/ERK signaling pathway (2008) J Bone Miner Res, 23, pp. 278-286
  • Kopitz, J., Ballikaya, S., Andre, S., Gabius, H.J., Ganglioside GM1/galectin-dependent growth regulation in human neuroblastoma cells: Special properties of bivalent galectin-4 and significance of linker length for ligand selection (2012) Neurochem Res, 37, pp. 1267-1276
  • Garner, O.B., Baum, L.G., Galectin-glycan lattices regulate cellsurface glycoprotein organization and signaling (2008) Biochem Soc Trans, 36, pp. 1472-1477
  • Earl, L.A., Bi, S., Baum, L.G., N- and O-glycans modulate galectin-1 binding, CD45 signaling, and T cell death (2010) J Biol Chem, 285, pp. 2232-2244
  • Walzel, H., Fahmi, A.A., Eldesouky, M.A., Effects of Nglycan processing inhibitors on signaling events and induction of apoptosis in galectin-1-stimulated Jurkat T lymphocytes (2006) Glycobiology, 16, pp. 1262-1271
  • Motran, C.C., Molinder, K.M., Liu, S.D., Poirier, F., Miceli, M.C., Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function (2008) Eur J Immunol, 38, pp. 3015-3027
  • Endharti, A.T., Zhou, Y.W., Nakashima, I., Suzuki, H., Galectin-1 supports survival of naive T cells without promoting cell proliferation (2005) Eur J Immunol, 35, pp. 86-97
  • Brandt, B., Buchse, T., Abou-Eladab, E.F., Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes (2008) Histochem Cell Biol, 129, pp. 599-609
  • Lange, F., Brandt, B., Tiedge, M., Galectin-1 induced activation of the mitochondrial apoptotic pathway: Evidence for a connection between death-receptor and mitochondrial pathways in human Jurkat T lymphocytes (2009) Histochem Cell Biol, 132, pp. 211-223
  • Ion, G., Fajka-Boja, R., Kovacs, F., Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1 (2006) Cell Signal, 18, pp. 1887-1896
  • Rabinovich, G.A., Alonso, C.R., Sotomayor, C.E., Durand, S., Bocco, J.L., Riera, C.M., Molecular mechanisms implicated in galectin-1-induced apoptosis: Activation of the AP-1 transcription factor and downregulation of Bcl-2 (2000) Cell Death Differ, 7, pp. 747-753
  • Pace, K.E., Hahn, H.P., Pang, M., Nguyen, J.T., Baum, L.G., CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death (2000) J Immunol, 165, pp. 2331-2334
  • Hahn, H.P., Pang, M., He, J., Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death (2004) Cell Death Differ, 11, pp. 1277-1286
  • van der Leij, J., van den Berg, A., Harms, G., Strongly enhanced IL-10 production using stable galectin-1 homodimers (2007) Mol Immunol, 44, pp. 506-513
  • Earl, L.A., Bi, S., Baum, L.G., Galectin multimerization and lattice formation are regulated by linker region structure (2011) Glycobiology, 21, pp. 6-12
  • Cedeno-Laurent, F., Barthel, S.R., Opperman, M.J., Lee, D.M., Clark, R.A., Dimitroff, C.J., Development of a nascent galectin-1 chimeric molecule for studying the role of leukocyte galectin- 1 ligands and immune disease modulation (2010) J Immunol, 185, pp. 4659-4672
  • Ellerhorst, J., Nguyen, T., Cooper, D.N., Estrov, Y., Lotan, D., Lotan, R., Induction of differentiation and apoptosis in the prostate cancer cell line LNCaP by sodium butyrate and galectin-1 (1999) Int J Oncol, 14, pp. 225-232
  • Stowell, S.R., Karmakar, S., Arthur, C.M., Galectin-1 induces reversible phosphatidylserine exposure at the plasma membrane (2009) Mol Biol Cell, 20, pp. 1408-1418
  • Garin, M.I., Chu, C.C., Golshayan, D., Cernuda-Morollon, E., Wait, R., Lechler, R.I., Galectin-1: A key effector of regulation mediated by CD4+CD25+ T cells (2007) Blood, 109, pp. 2058-2065
  • Sugimoto, N., Oida, T., Hirota, K., Foxp3-dependent and - independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis (2006) Int Immunol, 18, pp. 1197-1209
  • Baatar, D., Olkhanud, P.B., Wells, V., Indig, F.E., Mallucci, L., Biragyn, A., Tregs utilize beta-galactoside-binding protein to transiently inhibit PI3K/p21ras activity of human CD8+ T cells to block their TCR-mediated ERK activity and proliferation (2009) Brain Behav Immun, 23, pp. 1028-1037
  • Wang, J., Lu, Z.H., Gabius, H.J., Rohowsky-Kochan, C., Ledeen, R.W., Wu, G., Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: Possible role in suppressing experimental autoimmune encephalomyelitis (2009) J Immunol, 182, pp. 4036-4045
  • Cedeno-Laurent, F., Opperman, M., Barthel, S.R., Kuchroo, V.K., Dimitroff, C.J., Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression (2012) J Immunol, 188, pp. 3127-3137
  • Kubach, J., Lutter, P., Bopp, T., Human CD4+CD25+ regulatory T cells: Proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function (2007) Blood, 110, pp. 1550-1558
  • Barrionuevo, P., Beigier-Bompadre, M., Ilarregui, J.M., A novel function for galectin-1 at the crossroad of innate and adaptive immunity: Galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway (2007) J Immunol, 178, pp. 436-445
  • Malik, R.K., Ghurye, R.R., Lawrence-Watt, D.J., Stewart, H.J., Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway (2009) Glycobiology, 19, pp. 1402-1407
  • Ortner, D., Grabher, D., Hermann, M., Kremmer, E., Hofer, S., Heufler, C., The adaptor protein Bam32 in human dendritic cells participates in the regulation of MHC class I-induced CD8+ T cell activation (2011) J Immunol, 187, pp. 3972-3978
  • Fulcher, J.A., Hashimi, S.T., Levroney, E.L., Galectin-1- matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix (2006) J Immunol, 177, pp. 216-226
  • Fulcher, J.A., Chang, M.H., Wang, S., Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling (2009) J Biol Chem, 284, pp. 26860-26870
  • Mourcin, F., Breton, C., Tellier, J., Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow (2011) Blood, 117, pp. 6552-6561
  • Elantak, L., Espeli, M., Boned, A., Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation (2012) J Biol Chem, 287, pp. 44703-44713
  • Gauthier, L., Rossi, B., Roux, F., Termine, E., Schiff, C., Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering (2002) Proc Natl Acad Sci U S A, 99, pp. 13014-13019
  • Rossi, B., Espeli, M., Schiff, C., Gauthier, L., Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation (2006) J Immunol, 177, pp. 796-803
  • Lecourt, S., Lepelletier, Y., Vanneaux, V., Human Muscle Progenitor Cells Displayed Immunosuppressive Effect through Galectin-1 and Semaphorin-3A Stem Cells Int, 2012 (41), p. 2012
  • Lepelletier, Y., Lecourt, S., Renand, A., Galectin-1 and semaphorin-3A are two soluble factors conferring T-cell immunosuppression to bone marrow mesenchymal stem cell (2010) Stem Cells Dev, 19, pp. 1075-1079
  • Jouve, N., Despoix, N., Espeli, M., The involvement of CD146 and its novel ligand Galectin-1 in apoptotic regulation of endothelial cells (2011) J Biol Chem, 288, pp. 2571-2579
  • Hsieh, S.H., Ying, N.W., Wu, M.H., Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells (2008) Oncogene, 27, pp. 3746-3753
  • Laderach, D.J., Gentilini, L.D., Giribaldi, L., A Unique Galectin Signature in Human Prostate Cancer Progression Suggests Galectin-1 as a Key Target for Treatment of Advanced Disease (2013) Cancer Res, 73, pp. 86-96
  • Croci, D.O., Salatino, M., Rubinstein, N., Disrupting galectin-1 interactions with N-glycans suppresses hypoxiadriven angiogenesis and tumorigenesis in Kaposi's sarcoma (2012) J Exp Med, 209, pp. 1985-2000
  • Fischer, I., Weber, M., Kuhn, C., Is galectin-1 a trigger for trophoblast cell fusion?: The MAP-kinase pathway and syncytium formation in trophoblast tumour cells BeWo (2011) Mol Hum Reprod, 17, pp. 747-757
  • Fischer, I., Schulze, S., Kuhn, C., Inhibiton of RET and JAK2 signals and upregulation of VEGFR3 phosphorylation in vitro by galectin-1 in trophoblast tumor cells BeWo (2009) Placenta, 30, pp. 1078-1082
  • Thijssen, V.L., Postel, R., Brandwijk, R.J., Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy (2006) Proc Natl Acad Sci U S A, 103, pp. 15975-15980
  • Sturm, A., Lensch, M., Andre, S., Human galectin-2: Novel inducer of T cell apoptosis with distinct profile of caspase activation (2004) J Immunol, 173, pp. 3825-3837
  • Kashio, Y., Nakamura, K., Abedin, M.J., Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway (2003) J Immunol, 170, pp. 3631-3636
  • Oomizu, S., Arikawa, T., Niki, T., Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3- independent manner (2012) Clin Immunol, 143, pp. 51-58
  • Lu, L.H., Nakagawa, R., Kashio, Y., Characterization of galectin-9-induced death of Jurkat T cells (2007) J Biochem, 141, pp. 157-172
  • Dai, S.Y., Nakagawa, R., Itoh, A., Galectin-9 induces maturation of human monocyte-derived dendritic cells (2005) J Immunol, 175, pp. 2974-2981
  • Wang, F., Wan, L., Zhang, C., Zheng, X., Li, J., Chen, Z.K., Tim-3- Galectin-9 pathway involves the suppression induced by CD4+CD25+ regulatory T cells (2009) Immunobiology, 214, pp. 342-349
  • Seki, M., Oomizu, S., Sakata, K.M., Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis (2008) Clin Immunol, 127, pp. 78-88
  • Imaizumi, T., Yoshida, H., Nishi, N., Double-stranded RNA induces galectin-9 in vascular endothelial cells: Involvement of TLR3, PI3K, and IRF3 pathway (2007) Glycobiology, 17, pp. 12C-15C
  • Tanikawa, R., Tanikawa, T., Hirashima, M., Yamauchi, A., Tanaka, Y., Galectin-9 induces osteoblast differentiation through the CD44/Smad signaling pathway (2010) Biochem Biophys Res Commun, 394, pp. 317-322
  • Kobayashi, T., Kuroda, J., Ashihara, E., Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways (2010) Leukemia, 24, pp. 843-850
  • Eshkar, S.L., Ronen, D., Levartovsky, D., The involvement of CD44 and its novel ligand galectin-8 in apoptotic regulation of autoimmune inflammation (2007) J Immunol, 179, pp. 1225-1235
  • Arbel-Goren, R., Levy, Y., Ronen, D., Zick, Y., Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8 (2005) J Biol Chem, 280, pp. 19105-19114
  • Cattaneo, V., Tribulatti, M.V., Campetella, O., Galectin-8 tandemrepeat structure is essential for T-cell proliferation but not for co-stimulation (2011) Biochem J, 434, pp. 153-160
  • Tribulatti, M.V., Cattaneo, V., Hellman, U., Mucci, J., Campetella, O., Galectin-8 provides costimulatory and proliferative signals to T lymphocytes (2009) J Leukoc Biol, 86, pp. 371-380
  • Tribulatti, M.V., Mucci, J., Cattaneo, V., Galectin-8 induces apoptosis in the CD4(high)CD8(high) thymocyte subpopulation (2007) Glycobiology, 17, pp. 1404-1412
  • Norambuena, A., Metz, C., Vicuna, L., Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic acid-mediated ERK1/2 activation supported by protein kinase A downregulation (2009) J Biol Chem, 284, pp. 12670-12679
  • Ideo, H., Seko, A., Yamashita, K., Galectin-4 binds to sulfated glycosphingolipids and carcinoembryonic antigen in patches on the cell surface of human colon adenocarcinoma cells (2005) J Biol Chem, 280, pp. 4730-4737
  • Ideo, H., Seko, A., Yamashita, K., Recognition mechanism of galectin-4 for cholesterol 3-sulfate (2007) J Biol Chem, 282, pp. 21081-21089
  • Strott, C.A., Higashi, Y., Cholesterol sulfate in human physiology: What's it all about? (2003) J Lipid Res, 44, pp. 1268-1278
  • Williams, M.L., Hughes-Fulford, M., Elias, P.M., Inhibition of 3- hydroxy-3-methylglutaryl coenzyme A reductase activity and sterol synthesis by cholesterol sulfate in cultured fibroblasts (1985) Biochim Biophys Acta, 845, pp. 349-357
  • Huflejt, M.E., Jordan, E.T., Gitt, M.A., Barondes, S.H., Leffler, H., Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion (1997) J Biol Chem, 272, pp. 14294-14303
  • Hokama, A., Mizoguchi, E., Sugimoto, K., Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation (2004) Immunity, 20, pp. 681-693
  • Paclik, D., Danese, S., Berndt, U., Wiedenmann, B., Dignass, A., Sturm, A., Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycle (2008) PLoS ONE, 3, pp. e2629
  • Matarrese, P., Tinari, N., Semeraro, M.L., Natoli, C., Iacobelli, S., Malorni, W., Galectin-3 overexpression protects from cell damage and death by influencing mitochondrial homeostasis (2000) FEBS Lett, 473, pp. 311-315
  • Fukumori, T., Takenaka, Y., Yoshii, T., CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis (2003) Cancer Res, 63, pp. 8302-8311
  • Stillman, B.N., Hsu, D.K., Pang, M., Galectin-3 and galectin- 1 bind distinct cell surface glycoprotein receptors to induce T cell death (2006) J Immunol, 176, pp. 778-789
  • Hughes, R.C., Galectins as modulators of cell adhesion (2001) Biochimie, 83, pp. 667-676
  • Dong, S., Hughes, R.C., Galectin-3 stimulates uptake of extracellular Ca2+ in human Jurkat T-cells (1996) FEBS Lett, 395, pp. 165-169
  • Demetriou, M., Granovsky, M., Quaggin, S., Dennis, J.W., Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation (2001) Nature, 409, pp. 733-739
  • Sano, H., Hsu, D.K., Apgar, J.R., Critical role of galectin-3 in phagocytosis by macrophages (2003) J Clin Invest, 112, pp. 389-397
  • Howes, M.T., Kirkham, M., Riches, J., Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells (2010) J Cell Biol, 190, pp. 675-691
  • Schneider, D., Greb, C., Koch, A., Trafficking of galectin-3 through endosomal organelles of polarized and nonpolarized cells (2010) Eur J Cell Biol, 89, pp. 788-798
  • Liu, W., Hsu, D.K., Chen, H.Y., Galectin-3 Regulates Intracellular Trafficking of EGFR through Alix and Promotes Keratinocyte Migration (2012) J Invest Dermatol, 132, pp. 2828-2837
  • Falguieres, T., Luyet, P.P., Bissig, C., Scott, C.C., Velluz, M.C., Gruenberg, J., In vitro budding of intralumenal vesicles into late endosomes is regulated by Alix and Tsg101 (2008) Mol Biol Cell, 19, pp. 4942-4955
  • Probstmeier, R., Montag, D., Schachner, M., Galectin-3, a betagalactoside- binding animal lectin, binds to neural recognition molecules (1995) J Neurochem, 64, pp. 2465-2472
  • Delacour, D., Cramm-Behrens, C.I., Drobecq, H., Le Bivic, A., Naim, H.Y., Jacob, R., Requirement for galectin-3 in apical protein sorting (2006) Curr Biol, 16, pp. 408-414
  • Delacour, D., Koch, A., Ackermann, W., Loss of galectin-3 impairs membrane polarisation of mouse enterocytes in vivo (2008) J Cell Sci, 121, pp. 458-465
  • Ohannesian, D.W., Lotan, D., Thomas, P., Carcinoembryonic antigen and other glycoconjugates act as ligands for galectin-3 in human colon carcinoma cells (1995) Cancer Res, 55, pp. 2191-2199
  • Mazurek, N., Byrd, J.C., Sun, Y., Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells (2012) Cell Death Differ, 19, pp. 523-533
  • Fukumori, T., Oka, N., Takenaka, Y., Galectin-3 regulates mitochondrial stability and antiapoptotic function in response to anticancer drug in prostate cancer (2006) Cancer Res, 66, pp. 3114-3119
  • Clark, M.C., Pang, M., Hsu, D.K., Galectin-3 binds to CD45 on diffuse large B-cell lymphoma cells to regulate susceptibility to cell death (2012) Blood, 120, pp. 4635-4644
  • Sato, S., Hughes, R.C., Binding specificity of a baby hamster kidney lectin for H type I and II chains, polylactosamine glycans, and appropriately glycosylated forms of laminin and fibronectin (1992) J Biol Chem, 267, pp. 6983-6990
  • Zhou, Q., Cummings, R.D., The S-type lectin from calf heart tissue binds selectively to the carbohydrate chains of laminin (1990) Arch Biochem Biophys, 281, pp. 27-35
  • Ozeki, Y., Matsui, T., Yamamoto, Y., Funahashi, M., Hamako, J., Titani, K., Tissue fibronectin is an endogenous ligand for galectin-1 (1995) Glycobiology, 5, pp. 255-261
  • Goetz, J.G., Joshi, B., Lajoie, P., Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosinephosphorylated caveolin-1 (2008) J Cell Biol, 180, pp. 1261-1275
  • Levy, Y., Ronen, D., Bershadsky, A.D., Zick, Y., Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin (2003) J Biol Chem, 278, pp. 14533-14542
  • Alge-Priglinger, C.S., Andre, S., Kreutzer, T.C., Inhibition of human retinal pigment epithelial cell attachment, spreading, and migration by the human lectin galectin-1 (2009) Mol Vis, 15, pp. 2162-2173
  • Espelt, M.V., Croci, D.O., Bacigalupo, M.L., Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization, and in vivo tumor growth (2011) Hepatology, 53, pp. 2097-2106
  • Saravanan, C., Liu, F.T., Gipson, I.K., Panjwani, N., Galectin-3 promotes lamellipodia formation in epithelial cells by interacting with complex N-glycans on alpha3beta1 integrin (2009) J Cell Sci, 122, pp. 3684-3693
  • Alge-Priglinger, C.S., Andre, S., Schoeffl, H., Negative regulation of RPE cell attachment by carbohydratedependent cell surface binding of galectin-3 and inhibition of the ERK-MAPK pathway (2011) Biochimie, 93, pp. 477-488
  • Diskin, S., Chen, W.S., Cao, Z., Galectin-8 promotes cytoskeletal rearrangement in trabecular meshwork cells through activation of Rho signaling (2012) PLoS One, 7, pp. e44400
  • Matarrese, P., Fusco, O., Tinari, N., Galectin-3 overexpression protects from apoptosis by improving cell adhesion properties (2000) Int J Cancer, 85, pp. 545-554
  • van den Brule, F.A., Liu, F.T., Castronovo, V., Transglutaminasemediated oligomerization of galectin-3 modulates human melanoma cell interactions with laminin (1998) Cell Adhes Commun, 5, pp. 425-435
  • Mehul, B., Bawumia, S., Hughes, R.C., Cross-linking of galectin 3, a galactose-binding protein of mammalian cells, by tissuetype transglutaminase (1995) FEBS Lett, 360, pp. 160-164
  • Le Marer, N., Hughes, R.C., Effects of the carbohydrate-binding protein galectin-3 on the invasiveness of human breast carcinoma cells (1996) J Cell Physiol, 168, pp. 51-58
  • Larsen, M., Artym, V.V., Green, J.A., Yamada, K.M., The matrix reorganized: Extracellular matrix remodeling and integrin signaling (2006) Curr Opin Cell Biol, 18, pp. 463-471
  • Partridge, E.A., Le Roy, C., Di Guglielmo, G.M., Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis (2004) Science, 306, pp. 120-124
  • Reticker-Flynn, N.E., Malta, D.F., Winslow, M.M., A combinatorial extracellular matrix platform identifies cellextracellular matrix interactions that correlate with metastasis (2012) Nat Commun, 3, p. 1122
  • Dalotto-Moreno, T., Croci, D.O., Cerliani, J.P., Targeting galectin-1 overcomes breast cancer associated immunosuppression and prevents metastatic disease (2013) Cancer Res, 73, pp. 1107-1117
  • Klibi, J., Niki, T., Riedel, A., Blood diffusion and Th1- suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells (2009) Blood, 113, pp. 1957-1966
  • Welton, J.L., Khanna, S., Giles, P.J., Proteomics analysis of bladder cancer exosomes (2010) Mol Cell Proteomics, 9, pp. 1324-1338
  • Carlsson, M.C., Balog, C.I., Kilsgard, O., Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease (2012) Biochim Biophys Acta, 1820, pp. 1366-1372
  • Cederfur, C., Salomonsson, E., Nilsson, J., Different affinity of galectins for human serum glycoproteins: Galectin-3 binds many protease inhibitors and acute phase proteins (2008) Glycobiology, 18, pp. 384-394
  • Romaniuk, M.A., Tribulatti, M.V., Cattaneo, V., Human platelets express and are activated by galectin-8 (2010) Biochem J, 432, pp. 535-547
  • Gruson, D., Ko, G., Galectins testing: New promises for the diagnosis and risk stratification of chronic diseases? (2012) Clin Biochem, 45, pp. 719-726
  • Iwamoto, M., Taguchi, C., Sasaguri, K., The Galectin-1 level in serum as a novel marker for stress (2010) Glycoconj J, 27, pp. 419-425
  • Hirabayashi, J., Hashidate, T., Arata, Y., Oligosaccharide specificity of galectins: A search by frontal affinity chromatography (2002) Biochim Biophys Acta, 1572, pp. 232-254
  • Yang, R.Y., Rabinovich, G.A., Liu, F.T., Galectins: Structure, function and therapeutic potential (2008) Expert Rev Mol Med, 10, pp. e17
  • Fuster, M.M., Esko, J.D., The sweet and sour of cancer: Glycans as novel therapeutic targets (2005) Nat Rev Cancer, 5, pp. 526-542
  • Lagana, A., Goetz, J.G., Cheung, P., Raz, A., Dennis, J.W., Nabi, I.R., Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells (2006) Mol Cell Biol, 26, pp. 3181-3193
  • Krzeminski, M., Singh, T., Andre, S., Human galectin-3 (Mac-2 antigen): Defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region (2011) Biochim Biophys Acta, 1810, pp. 150-161
  • Vokhmyanina, O.A., Rapoport, E.M., Andre, S., Comparative study of the glycan specificities of cell-bound human tandemrepeat- type galectin-4, -8 and -9 (2012) Glycobiology, 22, pp. 1207-1217
  • Wu, A.M., Singh, T., Liu, J.H., Adhesion/growth-regulatory galectins: Insights into their ligand selectivity using natural glycoproteins and glycotopes (2011) Adv Exp Med Biol, 705, pp. 117-141
  • Al-Ansari, S., Zeebregts, C.J., Slart, R.H., Peppelenbosch, M., Tio, R.A., Galectins in atherosclerotic disease (2009) Trends Cardiovasc Med, 19, pp. 164-169
  • Liu, X., Feng, Q., Chen, Y., Proteomics-based identification of differentially-expressed proteins including galectin-1 in the blood plasma of type 2 diabetic patients (2009) J Proteome Res, 8, pp. 1255-1262
  • Weigert, J., Neumeier, M., Wanninger, J., Serum galectin-3 is elevated in obesity and negatively correlates with glycosylated hemoglobin in type 2 diabetes (2010) J Clin Endocrinol Metab, 95, pp. 1404-1411
  • de Boer, R.A., Yu, L., van Veldhuisen, D.J., Galectin-3 in cardiac remodeling and heart failure (2010) Curr Heart Fail Rep, 7, pp. 1-8
  • Sharma, U.C., Pokharel, S., van Brakel, T.J., Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction (2004) Circulation, 110, pp. 3121-3128
  • van Kimmenade, R.R., Januzzi Jr., J.L., Ellinor, P.T., Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure (2006) J Am Coll Cardiol, 48, pp. 1217-1224
  • Freitag, N., Tirado-Gonzalez, I., Barrientos, G., Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia (2013) Proc Natl Acad Sci U S A, 110, pp. 11451-11456
  • Ramhorst, R.E., Giribaldi, L., Fraccaroli, L., Galectin-1 confers immune privilege to human trophoblast: Implications in recurrent fetal loss (2012) Glycobiology, 22, pp. 1374-1386
  • Blois, S.M., Ilarregui, J.M., Tometten, M., A pivotal role for galectin-1 in fetomaternal tolerance (2007) Nat Med, 13, pp. 1450-1457
  • Odegard, R.A., Vatten, L.J., Nilsen, S.T., Salvesen, K.A., Austgulen, R., Preeclampsia and fetal growth (2000) Obstet Gynecol, 96, pp. 950-955
  • Sammar, M., Nisemblat, S., Fleischfarb, Z., Placentabound and body fluid PP13 and its mRNA in normal pregnancy compared to preeclampsia, HELLP and preterm delivery (2011) Placenta, 32 (SUPPL.), pp. S30-S36
  • Hittelet, A., Legendre, H., Nagy, N., Upregulation of galectins-1 and -3 in human colon cancer and their role in regulating cell migration (2003) Int J Cancer, 103, pp. 370-379
  • Schoeppner, H.L., Raz, A., Ho, S.B., Bresalier, R.S., Expression of an endogenous galactose-binding lectin correlates with neoplastic progression in the colon (1995) Cancer, 75, pp. 2818-2826
  • Zaia, P.L., Oshima, C.T., de Oliveira, L.F., Andrade, S.P.L., Manoukian, F.N., Immunoexpression of galectin-3 in colorectal cancer and its relationship with survival (2011) J Gastrointest Cancer, 42, pp. 217-221
  • Watanabe, M., Takemasa, I., Kaneko, N., Clinical significance of circulating galectins as colorectal cancer markers (2011) Oncol Rep, 25, pp. 1217-1226
  • Wiseman, S.M., Melck, A., Masoudi, H., Molecular phenotyping of thyroid tumors identifies a marker panel for differentiated thyroid cancer diagnosis (2008) Ann Surg Oncol, 15, pp. 2811-3826
  • Chiu, C.G., Strugnell, S.S., Griffith, O.L., Diagnostic utility of galectin-3 in thyroid cancer (2010) Am J Pathol, 176, pp. 2067-2081
  • Compagno, D., Laderach, D.J., Gentilini, L., Jaworski, F.M., Rabinovich, G.A., Delineating the galectin signature of the tumor microenvironment (2013) Oncoimmunology, 2, pp. e23565
  • van den Brule, F.A., Waltregny, D., Liu, F.T., Castronovo, V., Alteration of the cytoplasmic/nuclear expression pattern of galectin-3 correlates with prostate carcinoma progression (2000) Int J Cancer, 89, pp. 361-367
  • Carlsson, M.C., Cederfur, C., Schaar, V., Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients (2011) PLoS One, 6, pp. e26560
  • Giordano, M., Croci, D.O., Rabinovich, G.A., Galectins in hematological malignancies (2013) Curr Opin Hematol, 20, pp. 327-335
  • Boscher, C., Dennis, J.W., Nabi, I.R., Glycosylation, galectins and cellular signaling (2011) Curr Opin Cell Biol, 23, pp. 383-392

Citas:

---------- APA ----------
Compagno, D., Jaworski, F.M., Gentilini, L., Contrufo, G., Pérez, I.G., Elola, M.T., Pregi, N.,..., Laderach, D.J. (2014) . Galectins: Major signaling modulators inside and outside the cell. Current Molecular Medicine, 14(5), 630-651.
http://dx.doi.org/10.2174/1566524014666140603101953
---------- CHICAGO ----------
Compagno, D., Jaworski, F.M., Gentilini, L., Contrufo, G., Pérez, I.G., Elola, M.T., et al. "Galectins: Major signaling modulators inside and outside the cell" . Current Molecular Medicine 14, no. 5 (2014) : 630-651.
http://dx.doi.org/10.2174/1566524014666140603101953
---------- MLA ----------
Compagno, D., Jaworski, F.M., Gentilini, L., Contrufo, G., Pérez, I.G., Elola, M.T., et al. "Galectins: Major signaling modulators inside and outside the cell" . Current Molecular Medicine, vol. 14, no. 5, 2014, pp. 630-651.
http://dx.doi.org/10.2174/1566524014666140603101953
---------- VANCOUVER ----------
Compagno, D., Jaworski, F.M., Gentilini, L., Contrufo, G., Pérez, I.G., Elola, M.T., et al. Galectins: Major signaling modulators inside and outside the cell. Curr. Mol. Med. 2014;14(5):630-651.
http://dx.doi.org/10.2174/1566524014666140603101953