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Abstract:

The multiple steps that contribute to gene expression in the metazoan but in theory does not necessarily imply coupling of transcription with process-nucleus are highly integrated and regulated. Most of pre-mRNA processing is believed to occur co-transcriptionally and choices regarding alternative processing reactions are influenced by transcription. Several articles published in the last year unveiled a connection between chromatin structure and the splicing process, strengthening a view in which the dynamic of intragenic chromatin modifications has an important role regulating alternative splicing (AS) choices. We have recently shown that both neuronal cell depolarization and the use of double stranded small RNAs targeting intragenic regions can modulate AS through chromatin remodeling, taking advantage of the kinetic coupling between splicing and transcription. Here, we discuss the many ways in which intragenic chromatin can participate in alternative splicing regulation. © 2010 Landes Bioscience.

Registro:

Documento: Artículo
Título:Intragenic chromatin modifications: A new layer in alternative splicing regulation
Autor:Schor, I.E.; Alló, M.; Kornblihtt, A.R.
Filiación:Laboratorio de Fisiología, Biologia Molecular; Departamento de Fisiologia; Biologia Molecular y Celular; IFIBYNE-CONICET, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
Palabras clave:Alternative splicing; Histone modifications; Intragenic chromatin; Noncoding RNA; Nucleosome positioning; SiRNA; Transcription; Transcriptional gene silencing; double stranded RNA; messenger RNA; chromatin; small interfering RNA; alternative RNA splicing; article; cell nucleus; chromatin; chromatin assembly and disassembly; depolarization; DNA modification; DNA sequence; exon; gene expression; gene targeting; metazoon; nerve cell; nonhuman; nucleosome; RNA processing; RNA splicing; RNA transcription; Adenoviridae; animal; chromatin; chromatin assembly and disassembly; genetics; human; metabolism; transcription elongation; Metazoa; Adenoviridae; Alternative Splicing; Animals; Chromatin; Chromatin Assembly and Disassembly; Humans; RNA, Small Interfering; Transcription Elongation, Genetic
Año:2010
Volumen:5
Número:3
Página de inicio:174
Página de fin:179
DOI: http://dx.doi.org/10.4161/epi.5.3.11316
Título revista:Epigenetics
Título revista abreviado:Epigenetics
ISSN:15592294
CAS:Chromatin; RNA, Small Interfering
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15592294_v5_n3_p174_Schor

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Citas:

---------- APA ----------
Schor, I.E., Alló, M. & Kornblihtt, A.R. (2010) . Intragenic chromatin modifications: A new layer in alternative splicing regulation. Epigenetics, 5(3), 174-179.
http://dx.doi.org/10.4161/epi.5.3.11316
---------- CHICAGO ----------
Schor, I.E., Alló, M., Kornblihtt, A.R. "Intragenic chromatin modifications: A new layer in alternative splicing regulation" . Epigenetics 5, no. 3 (2010) : 174-179.
http://dx.doi.org/10.4161/epi.5.3.11316
---------- MLA ----------
Schor, I.E., Alló, M., Kornblihtt, A.R. "Intragenic chromatin modifications: A new layer in alternative splicing regulation" . Epigenetics, vol. 5, no. 3, 2010, pp. 174-179.
http://dx.doi.org/10.4161/epi.5.3.11316
---------- VANCOUVER ----------
Schor, I.E., Alló, M., Kornblihtt, A.R. Intragenic chromatin modifications: A new layer in alternative splicing regulation. Epigenetics. 2010;5(3):174-179.
http://dx.doi.org/10.4161/epi.5.3.11316