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Abstract:

Herein we describe the synthesis of a set of heterocyclic analogues of topiramate as possible therapeutic agents for epileptic seizure treatment. The new compounds and their precursors were characterized by physical, as well as spectroscopic techniques. We verified that the preferential conformation in solution of the carbohydrate ring is twist-boat. The stereochemistry of the new asymmetric centre, generated during the heterocyclizations, was proposed using NOESY experiment. These novel compounds could help to elucidate the mechanism of action of the commercial drug used for this disease. © ARKAT-USA, Inc.

Registro:

Documento: Artículo
Título:Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization
Autor:Alho, M.A.M.; D'Accorso, N.
Filiación:Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR-CONICET), Departamento de Química Orgánica, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina
Palabras clave:D-fructose; Heterocyclic rings; Spectroscopic data; Topiramate
Año:2011
Volumen:2011
Número:7
Página de inicio:136
Página de fin:148
DOI: http://dx.doi.org/10.3998/ark.5550190.0012.712
Título revista:Arkivoc
Título revista abreviado:Arkivoc
ISSN:1551-701
CODEN:AGFUA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1551-701_v2011_n7_p136_Alho

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Citas:

---------- APA ----------
Alho, M.A.M. & D'Accorso, N. (2011) . Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization. Arkivoc, 2011(7), 136-148.
http://dx.doi.org/10.3998/ark.5550190.0012.712
---------- CHICAGO ----------
Alho, M.A.M., D'Accorso, N. "Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization" . Arkivoc 2011, no. 7 (2011) : 136-148.
http://dx.doi.org/10.3998/ark.5550190.0012.712
---------- MLA ----------
Alho, M.A.M., D'Accorso, N. "Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization" . Arkivoc, vol. 2011, no. 7, 2011, pp. 136-148.
http://dx.doi.org/10.3998/ark.5550190.0012.712
---------- VANCOUVER ----------
Alho, M.A.M., D'Accorso, N. Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization. Arkivoc. 2011;2011(7):136-148.
http://dx.doi.org/10.3998/ark.5550190.0012.712