Friend, D.M.; Devarakonda, K.; O'Neal, T.J.; Skirzewski, M.; Papazoglou, I.; Kaplan, A.R.; Liow, J.-S.; Guo, J.; Rane, S.G.; Rubinstein, M.; Alvarez, V.A.; Hall, K.D.; Kravitz, A.V."Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity" (2017) Cell Metabolism. 25(2):312-321
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Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association are unknown. We hypothesized that deficits in dopamine signaling contribute to physical inactivity in obesity. To investigate this, we quantified multiple aspects of dopamine signaling in lean and obese mice. We found that D2-type receptor (D2R) binding in the striatum, but not D1-type receptor binding or dopamine levels, was reduced in obese mice. Genetically removing D2Rs from striatal medium spiny neurons was sufficient to reduce motor activity in lean mice, whereas restoring Gi signaling in these neurons increased activity in obese mice. Surprisingly, although mice with low D2Rs were less active, they were not more vulnerable to diet-induced weight gain than control mice. We conclude that deficits in striatal D2R signaling contribute to physical inactivity in obesity, but inactivity is more a consequence than a cause of obesity. © 2017


Documento: Artículo
Título:Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity
Autor:Friend, D.M.; Devarakonda, K.; O'Neal, T.J.; Skirzewski, M.; Papazoglou, I.; Kaplan, A.R.; Liow, J.-S.; Guo, J.; Rane, S.G.; Rubinstein, M.; Alvarez, V.A.; Hall, K.D.; Kravitz, A.V.
Filiación:National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, United States
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, United States
National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, United States
National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, United States
Section of Molecular Neurobiology, Eunice Shriver Kennedy National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, CONICET, C1428ADN Buenos Aires, Argentina
Department of Physiology, Molecular and Cellular Biology, FCEN, Universidad de Buenos Aires, C1428EGA Buenos Aires, Argentina
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, United States
Palabras clave:D2; dopamine; exercise; obese; obesity; physical activity; striatum; weight loss; dopamine; dopamine 2 receptor; protein binding; animal experiment; animal model; Article; basal ganglion; controlled study; corpus striatum; diet induced obesity; mouse; nerve cell; nonhuman; physical inactivity; priority journal; signal transduction; weight gain; action potential; adverse effects; animal; animal experiment; basal ganglion; C57BL mouse; lipid diet; male; metabolism; mouse mutant; movement (physiology); obesity; pathophysiology; physiology; Action Potentials; Animals; Basal Ganglia; Corpus Striatum; Diet, High-Fat; Male; Mice, Inbred C57BL; Mice, Obese; Movement; Neurons; Obesity; Physical Conditioning, Animal; Protein Binding; Receptors, Dopamine D2; Weight Gain
Página de inicio:312
Página de fin:321
Título revista:Cell Metabolism
Título revista abreviado:Cell Metab.
CAS:dopamine, 51-61-6, 62-31-7; Receptors, Dopamine D2


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---------- APA ----------
Friend, D.M., Devarakonda, K., O'Neal, T.J., Skirzewski, M., Papazoglou, I., Kaplan, A.R., Liow, J.-S.,..., Kravitz, A.V. (2017) . Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity. Cell Metabolism, 25(2), 312-321.
---------- CHICAGO ----------
Friend, D.M., Devarakonda, K., O'Neal, T.J., Skirzewski, M., Papazoglou, I., Kaplan, A.R., et al. "Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity" . Cell Metabolism 25, no. 2 (2017) : 312-321.
---------- MLA ----------
Friend, D.M., Devarakonda, K., O'Neal, T.J., Skirzewski, M., Papazoglou, I., Kaplan, A.R., et al. "Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity" . Cell Metabolism, vol. 25, no. 2, 2017, pp. 312-321.
---------- VANCOUVER ----------
Friend, D.M., Devarakonda, K., O'Neal, T.J., Skirzewski, M., Papazoglou, I., Kaplan, A.R., et al. Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity. Cell Metab. 2017;25(2):312-321.