Artículo

Moreno, F.; Sinaki, B.; Fandiño, A.; Dussel, V.; Orellana, L.; Chantada, G. "A population-based study of retinoblastoma incidence and survival in Argentine children" (2014) Pediatric Blood and Cancer. 61(9):1610-1615
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Abstract:

Background: An increased incidence of retinoblastoma in some developing countries has been reported but no conclusive data are available from population-based studies at national level. Purpose: To report the incidence and survival of retinoblastoma in Argentina from the National Pediatric Cancer Registry (ROHA) and the influence of socio-economical indicators on outcome. Procedure: Cases reported to the ROHA (2000-2009) were analyzed. Incidence rates were calculated using National Vital Statistics and survival was estimated. The extended human development index (EHDI) was used as a socio-economical indicator. Results: With 438 patients reported, an incidence of 5.0 cases per million children 0-14 years old (95% CI 3.5-6.4) was calculated. Median age at diagnosis was significantly higher for children from provinces with lower EHDI; (24 vs. 35 months for unilateral, (P=0.003) and 9 versus 11.5 months for bilateral retinoblastoma (P=0.027). The 3-year probability of survival was 0.87 and 0.94 for unilateral and bilateral retinoblastoma, respectively. Residents in provinces with higher EHDI had a better 3-year survival (0.93 vs. 0.77 for lower EHDI, P<0.0001). Probability of survival was higher for patients treated at tertiary level institutions (P=0.0015). The combination of low EHDI residence province with no treatment at a tertiary institution was associated with the worst survival outcome. For both, unilateral and bilateral disease, children who died were in average diagnosed at older age. Conclusions: The incidence of retinoblastoma in Argentina is comparable to that of developed countries. Retinoblastoma is diagnosed later and survival is lower in the less developed areas of the country. © 2014 Wiley Periodicals, Inc.

Registro:

Documento: Artículo
Título:A population-based study of retinoblastoma incidence and survival in Argentine children
Autor:Moreno, F.; Sinaki, B.; Fandiño, A.; Dussel, V.; Orellana, L.; Chantada, G.
Filiación:Registro Onco-pediatrico Hospitalario Argentino ROHA, Hospital-based Pediatric Cancer Registry from Argentina, Instituto Nacional del Cáncer, Buenos Aires, Argentina
Department of Pediatrics, New York Medical College, New York, NY, United States
Ophthalmology Service, Hospital JP Garrahan, Buenos Aires, Argentina
Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina
Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, MA, United States
Instituto de Cálculo, University of Buenos Aires, Buenos Aires, Argentina
Hematology-Oncology Service, Hospital JP Garrahan, Buenos Aires, Argentina
Palabras clave:Cancer; Children; Retinoblastoma; Survival; adolescent; Argentina; article; cancer incidence; cancer survival; child; developed country; female; human; major clinical study; male; mortality; preschool child; priority journal; resident; retinoblastoma; school child; socioeconomics; tertiary care center; cancer; children; retinoblastoma; survival; Adolescent; Argentina; Child; Child, Preschool; Cohort Studies; Female; Follow-Up Studies; Humans; Incidence; Infant; Infant, Newborn; Male; Prognosis; Registries; Retinal Neoplasms; Retinoblastoma; Survival Rate
Año:2014
Volumen:61
Número:9
Página de inicio:1610
Página de fin:1615
DOI: http://dx.doi.org/10.1002/pbc.25048
Título revista:Pediatric Blood and Cancer
Título revista abreviado:Pediatr. Blood Cancer
ISSN:15455009
CODEN:PBCEA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15455009_v61_n9_p1610_Moreno

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Citas:

---------- APA ----------
Moreno, F., Sinaki, B., Fandiño, A., Dussel, V., Orellana, L. & Chantada, G. (2014) . A population-based study of retinoblastoma incidence and survival in Argentine children. Pediatric Blood and Cancer, 61(9), 1610-1615.
http://dx.doi.org/10.1002/pbc.25048
---------- CHICAGO ----------
Moreno, F., Sinaki, B., Fandiño, A., Dussel, V., Orellana, L., Chantada, G. "A population-based study of retinoblastoma incidence and survival in Argentine children" . Pediatric Blood and Cancer 61, no. 9 (2014) : 1610-1615.
http://dx.doi.org/10.1002/pbc.25048
---------- MLA ----------
Moreno, F., Sinaki, B., Fandiño, A., Dussel, V., Orellana, L., Chantada, G. "A population-based study of retinoblastoma incidence and survival in Argentine children" . Pediatric Blood and Cancer, vol. 61, no. 9, 2014, pp. 1610-1615.
http://dx.doi.org/10.1002/pbc.25048
---------- VANCOUVER ----------
Moreno, F., Sinaki, B., Fandiño, A., Dussel, V., Orellana, L., Chantada, G. A population-based study of retinoblastoma incidence and survival in Argentine children. Pediatr. Blood Cancer. 2014;61(9):1610-1615.
http://dx.doi.org/10.1002/pbc.25048