Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis were observed. Griseofulvin (Gris) develops an experimental EPP with hepatic manifestations in mice such as PROTO IX accumulation followed by cellular damage as wells as necrotic and inflammatory processes. The antioxidant defense system was also altered. The aim was to evaluate the possible protective effect of different antioxidant compounds: trolox (Tx), ascorbic acid (Asc), the combination Tx and Asc, melatonin (Mel), and the polyphenols: ellagic acid, quercetin, chlorogenic acid, caffeic acid, gallic acid, and ferulic acid on liver damage and oxidative stress markers in a mouse model of EPP. Coadministration of Gris with Tx, Asc, and its combination, or Mel mainly affected heme biosynthetic pathway, resulting in a decrease in ALA-S activity which was increased by Gris, while the tested polyphenols exerted a protective effect on oxidative stress, decreasing lipid peroxidation and the activity of some antioxidant enzymes. In conclusion, antioxidant compounds can only protect partially against the liver damage induced by Gris, reducing oxidative stress or acting on heme regulation. © 2014 M. del C. Martinez et al.

Registro:

Documento: Artículo
Título:Protective action of antioxidants on hepatic damage induced by griseofulvin
Autor:Martinez, M.D.C.; Afonso, S.G.; Buzaleh, A.M.; Batlle, A.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Guiraldes 2160 Pab II, 1428 Buenos Aires, Argentina
Centro de Investigaciones Sobre Porfirinas y Porfirias (CIPYP), CONICET, Universidad de Buenos Aires, Avenida, Córdoba 2351 1er subsuelo, 1120 Buenos Aires, Argentina
Palabras clave:antifungal agent; antioxidant; biological marker; glutathione; griseofulvin; heme; superoxide dismutase; animal; article; disease model; male; metabolism; mouse; toxic hepatitis; Animals; Antifungal Agents; Antioxidants; Biological Markers; Disease Models, Animal; Drug-Induced Liver Injury; Glutathione; Griseofulvin; Heme; Male; Mice; Superoxide Dismutase
Año:2014
Volumen:2014
DOI: http://dx.doi.org/10.1155/2014/982358
Título revista:The Scientific World Journal
Título revista abreviado:Sci. World J.
ISSN:1537744X
CAS:glutathione, 70-18-8; griseofulvin, 126-07-8; heme, 14875-96-8; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1537744X_v2014_n_p_Martinez

Referencias:

  • Batlle, A., (1997) Porfirinas y Porfirias. Aspectos Clínicos, , Buenos Aires, Argentina Bioquímicos y Biología Molecular
  • Lecha, M., Puy, H., Deybach, J.-C., Erythropoietic protoporphyria (2009) Orphanet Journal of Rare Diseases, 4 (1). , 2-s2.0-70349330944 10.1186/1750-1172-4-19
  • Thunell, S., Harper, P., Brun, A., Porphyrins, porphyrin metabolism and porphyrias. IV. Pathophysiology of erythyropoietic protoporphyria - Diagnosis, care and monitoring of the patient (2000) Scandinavian Journal of Clinical and Laboratory Investigation, 60 (7), pp. 581-604. , DOI 10.1080/003655100448347
  • Cox, T.M., Kadish, K.M., Smith, K.M., Guilard, R., Protoporphyria (2003) The Porphyrin Handbook. Medical Aspects of Porphyrias, 14, pp. 121-149. , chapter 90 San Diego, Calif, USA Academic Press
  • Meerman, L., Erythropoietic protoporphyria. An overview with emphasis on the liver (2000) Scandinavian Journal of Gastroenterology, Supplement, 35 (232), pp. 79-85
  • Bruguera, M., Herrero, C., Liver disease in erythropoietic protoporphyria (2005) Gastroenterologia y Hepatologia, 28 (10), pp. 632-636. , 103.414
  • Shapiro, S.H., Wessely, Z., Ultrastructural changes of intrahepatic bile ductules in griseofulvin fed mice (1984) Annals of Clinical and Laboratory Science, 14 (1), pp. 69-77
  • Tanaka, K., Ohgami, T., Nonaka, S., Experimental murine protoporphyria induced by griseofulvin (GF): The relationship between hepatic porphyrin levels and liver function test values in mice treated with GF (1993) Journal of Dermatology, 20 (9), pp. 545-553
  • Polo, C.F., Buzaleh, A.M., Vazquez, E.S., Afonso, S.G., Navone, N.M., Del Carmen Batlle, A.M., Griseofulvin-induced hepatopathy due to abnormalities in heme pathways (1997) General Pharmacology, 29 (2), pp. 207-210. , DOI 10.1016/S0306-3623(96)00406-5, PII S0306362396004065
  • Inafuku, K., Takamiyagi, A., Oshiro, M., Kinjo, T., Nakashima, Y., Nonaka, S., Alteration of mRNA levels of δ-aminolevulinic acid synthase, ferrochelatase and heme oxygenase-1 in griseofulvin induced protoporphyria mice (1999) Journal of Dermatological Science, 19 (3), pp. 189-198. , DOI 10.1016/S0923-1811(98)00073-5, PII S0923181198000735
  • Martinez, M.D.C., Afonso, S.G., Meiss, R.P., Buzaleh, A.M., Batlle, A., Hepatic damage and oxidative stress induced by griseofulvin in mice (2009) Cellular and Molecular Biology, 55 (2), pp. 127-139. , 2-s2.0-68549098248 10.1170/T862
  • Thunell, S., Andersson, D., Harper, P., Henrichson, A., Floderus, Y., UlfLindh, Effects of administration of antioxidants in acute intermittent porphyria (1997) European Journal of Clinical Chemistry and Clinical Biochemistry, 35 (6), pp. 427-433
  • Princ, F.G., Maxit, A.G., Cardalda, C., Batlle, A., Juknat, A.A., In vivo protection by melatonin against δ-aminolevulinic acid-induced oxidative damage and its antioxidant effect on the activity of haem enzymes (1998) Journal of Pineal Research, 24 (1), pp. 1-8. , DOI 10.1111/j.1600-079X.1998.tb00359.x
  • Alemzadeh, R., Feehan, T., Variable effects of beta-carotene therapy in a child with erythropoietic protoporphyria (2004) European Journal of Pediatrics, 163 (9), pp. 547-549. , DOI 10.1007/s00431-004-1453-6
  • Anderson, K.E., Porphyria cutanea tarda: A possible role for ascorbic acid (2007) Hepatology, 45 (1), pp. 6-8. , DOI 10.1002/hep.21514
  • Szekely, E., Vereckei, A., Almasi, A., Rapavi, E., Tasnadi, Gy., Varnai, K., Pallai, Zs., Blazovics, A., Effects of vitamin E administration on the hemorheological status and redox homeostasis of patients with porphyria cutanea tarda treated with phlebotomy (2007) Clinical Hemorheology and Microcirculation, 36 (1), pp. 13-23
  • Ferrer, M.D., Tauler, P., Sureda, A., Palacín, C., Tur, J.A., Pons, A., Variegate porphyria induces plasma and neutrophil oxidative stress: Effects of dietary supplementation with vitamins e and C (2010) British Journal of Nutrition, 103 (1), pp. 69-76. , 2-s2.0-75549088242 10.1017/S0007114509991413
  • Brigelius-Flohe, R., Traber, M.G., Vitamin E: Function and metabolism (1999) FASEB Journal, 13 (10), pp. 1145-1155
  • Cuzzocrea, S., Thiemermann, C., Salvemini, D., Potential therapeutic effect of antioxidant therapy in shock and inflammation (2004) Current Medicinal Chemistry, 11 (9), pp. 1147-1162
  • Poljsak, B., Raspor, P., The antioxidant and pro-oxidant activity of vitamin C and trolox in vitro: A comparative study (2008) Journal of Applied Toxicology, 28 (2), pp. 183-188. , DOI 10.1002/jat.1264
  • Wu, T.-W., Hashimoto, N., Au, J.-X., Wu, J., Mickle, D.A.G., Carey, D., Trolox protects rat hepatocytes against oxyradical damage and the ischemic rat liver from reperfusion injury (1991) Hepatology, 13 (3), pp. 575-580. , 2-s2.0-0025897521 10.1016/0270-9139(91)90314-L
  • Kam Ming Ko, K.M.K., Pak Kin Yick, P.K.Y., Poon, M.K.T., Siu Po Ip, S.P.I., Prooxidant and antioxidant effects of trolox on ferric ion-induced oxidation of erythrocyte membrane lipids (1994) Molecular and Cellular Biochemistry, 141 (1), pp. 65-70. , 2-s2.0-0028595950 10.1007/BF00935592
  • Carr, A., Frei, B., Does vitamin C act as a pro-oxidant under physiological conditions? (1999) FASEB Journal, 13 (9), pp. 1007-1024
  • Kojo, S., Vitamin C: Basic metabolism and its function as an index of oxidative stress (2004) Current Medicinal Chemistry, 11 (8), pp. 1041-1064. , DOI 10.2174/0929867043455567
  • Ng, T.B., Liu, F., Zhao, L., Antioxidative and free radical scavenging activities of pineal indoles (2000) Journal of Neural Transmission, 107 (11), pp. 1243-1251. , 2-s2.0-0033746310 10.1007/s007020070014
  • Reiter, R.J., Tan, D.-X., Osuna, C., Gitto, E., Actions of melatonin in the reduction of oxidative stress: A review (2000) Journal of Biomedical Science, 7 (6), pp. 444-458. , 2-s2.0-0033768749
  • Manach, C., Scalbert, A., Morand, C., Remesy, C., Jimenez, L., Polyphenols: Food sources and bioavailability (2004) American Journal of Clinical Nutrition, 79 (5), pp. 727-747
  • Scalbert, A., Johnson, I.T., Saltmarsh, M., Polyphenols: Antioxidants and beyond (2005) The American Journal of Clinical Nutrition, 81 (1), pp. 215S-217S. , 2-s2.0-13844255694
  • Nichenametla, S.N., Taruscio, T.G., Barney, D.L., Exon, J.H., A review of the effects and mechanisms of polyphenolics in cancer (2006) Critical Reviews in Food Science and Nutrition, 46 (2), pp. 161-183. , 2-s2.0-33644617730 10.1080/10408390591000541
  • Polo, C.F., Frisardi, A.L., Resnik, E.R., Schoua, A.E.M., Del Batlle, C.A.M., Factors influencing fluorescence spectra of free porphyrins (1988) Clinical Chemistry, 34 (4), pp. 757-760. , 2-s2.0-0023942211
  • Marver, H.S., Tschudy, D.P., Perlroth, M.G., Collins, A., Delta-aminolevulinic acid synthetase. I. Studies in liver homogenates (1966) The Journal of Biological Chemistry, 193 (12), pp. 2803-2809. , 2-s2.0-0014027721
  • Ohkawa, H., Ohishi, N., Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction (1979) Analytical Biochemistry, 95 (2), pp. 351-358. , DOI 10.1016/0003-2697(79)90738-3
  • Rossi, R., Cardaioli, E., Scaloni, A., Amiconi, G., Di Simplicio, P., Thiol groups in proteins as endogenous reductants to determine glutathione-protein mixed disulphides in biological systems (1995) Biochimica et Biophysica Acta, 1243 (2), pp. 230-238. , 2-s2.0-0028872559 10.1016/0304-4165(94)00133-I
  • Habig, W.H., Pabst, M.J., Jakoby, W.B., Glutathione S transferases. The first enzymatic step in mercapturic acid formation (1974) The Journal of Biological Chemistry, 249 (22), pp. 7130-7139. , 2-s2.0-0016275313
  • Pinto, R.E., Bartley, W., The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates (1969) Biochemical Journal, 112 (1), pp. 109-115. , 2-s2.0-0014478046
  • Paoletti, F., Aldinucci, D., Mocali, A., Caparrini, A., A sensitive spectrophotometric method for the determination of superoxide dismutase activity in tissue extracts (1986) Analytical Biochemistry, 154 (2), pp. 536-541
  • Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent (1951) The Journal of Biological Chemistry, 193 (1), pp. 265-275. , 2-s2.0-71849104860
  • Frater, Y., Brady, A., Lock, E.A., De Matteis, F., Formation of N-methyl protoporphyrin in chemically-induced protoporphyria (1993) Archives of Toxicology, 67 (3), pp. 179-185. , 2-s2.0-0027477884
  • Bellingham, R.M.A., Gibbs, A.H., De Matteis, F., Lian, L.-Y., Roberts, G.C.K., Determination of the structure of an N-substituted protoporphyrin isolated from the livers of griseofulvin-fed mice (1995) Biochemical Journal, 307 (2), pp. 505-512. , 2-s2.0-0028903562
  • Wu, T.-W., Hashimoto, N., Wu, J., Carey, D., Li, R.-K., Mickle, D.A.G., Weisel, R.D., The cytoprotective effect of Trolox demonstrated with three types of human cells (1990) Biochemistry and Cell Biology, 68 (10), pp. 1189-1194
  • Burton, G.W., Ingold, K.U., Thompson, K.E., An improved procedure for the isolation of ghost membranes from human red blood cells (1981) Lipids, 16 (12), p. 946. , 2-s2.0-0019750550 10.1007/BF02535005
  • Gerez, E., Vazquez, E., Caballero, F., Polo, C., Batlle, A., Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal (1997) General Pharmacology, 29 (4), pp. 569-573. , DOI 10.1016/S0306-3623(96)00574-5, PII S0306362396005745
  • Hardeland, R., Pandi-Perumal, S.R., Melatonin, a potent agent in antioxidative defense: Actions as a natural food constituent, gastrointestinal factor, drug and prodrug (2005) Nutrition and Metabolism, 2, p. 22. , http://www.nutritionandmetabolism.com/content/pdf/1743-7075-2-22.pdf, DOI 10.1186/1743-7075-2-22
  • Tan, D.-X., Manchester, L.C., Terron, M.P., Flores, L.J., Reiter, R.J., One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species? (2007) Journal of Pineal Research, 42 (1), pp. 28-42. , DOI 10.1111/j.1600-079X.2006.00407.x
  • Tseng, T.-H., Wang, C.-J., Kao, E.-S., Chu, H.-Y., Hibiscus protocatechuic acid protects against oxidative damage induced by tert-butylhydroperoxide in rat primary hepatocytes (1996) Chemico-Biological Interactions, 101 (2), pp. 137-148. , DOI 10.1016/0009-2797(96)03721-0
  • Raneva, V., Shimasaki, H., Ishida, Y., Ueta, N., Niki, E., Antioxidative activity of 3,4-dihydroxyphenylacetic acid and caffeic acid in rat plasma (2001) Lipids, 36 (10), pp. 1111-1116
  • Sroka, Z., Cisowski, W., Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids (2003) Food and Chemical Toxicology, 41 (6), pp. 753-758. , DOI 10.1016/S0278-6915(02)00329-0

Citas:

---------- APA ----------
Martinez, M.D.C., Afonso, S.G., Buzaleh, A.M. & Batlle, A. (2014) . Protective action of antioxidants on hepatic damage induced by griseofulvin. The Scientific World Journal, 2014.
http://dx.doi.org/10.1155/2014/982358
---------- CHICAGO ----------
Martinez, M.D.C., Afonso, S.G., Buzaleh, A.M., Batlle, A. "Protective action of antioxidants on hepatic damage induced by griseofulvin" . The Scientific World Journal 2014 (2014).
http://dx.doi.org/10.1155/2014/982358
---------- MLA ----------
Martinez, M.D.C., Afonso, S.G., Buzaleh, A.M., Batlle, A. "Protective action of antioxidants on hepatic damage induced by griseofulvin" . The Scientific World Journal, vol. 2014, 2014.
http://dx.doi.org/10.1155/2014/982358
---------- VANCOUVER ----------
Martinez, M.D.C., Afonso, S.G., Buzaleh, A.M., Batlle, A. Protective action of antioxidants on hepatic damage induced by griseofulvin. Sci. World J. 2014;2014.
http://dx.doi.org/10.1155/2014/982358