Artículo
Salatino, M.; Girotti, M.R.; Rabinovich, G.A. "Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer" (2018) Cancer Cell. 33(2):155-157
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Abstract:
The clinical efficacy of therapies targeting the PD-1/PD-L1 pathway is still limited. In this issue of Cancer Cell, Li and colleagues identify a PD-L1 glycosylation-based mechanism in triple-negative breast cancer that fosters immunosuppression by enhancing interactions with PD-1. Targeting glycosylated PD-L1 with a drug-conjugated antibody opens new avenues for treatment. The clinical efficacy of therapies targeting the PD-1/PD-L1 pathway is still limited. In this issue of Cancer Cell, Li and colleagues identify a PD-L1 glycosylation-based mechanism in triple-negative breast cancer that fosters immunosuppression by enhancing interactions with PD-1. Targeting glycosylated PD-L1 with a drug-conjugated antibody opens new avenues for treatment. © 2018 Elsevier Inc.
Registro:
| Documento: | Artículo |
| Título: | Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer |
| Autor: | Salatino, M.; Girotti, M.R.; Rabinovich, G.A. |
| Filiación: | Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490, Buenos Aires, C1428ADN, Argentina Laboratorio de Inmuno-Oncología Traslacional, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490, Buenos Aires, C1428ADN, Argentina Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, Buenos Aires, C1428EGA, Argentina |
| Palabras clave: | asparagine linked oligosaccharide; epidermal growth factor; glycan; glycogen synthase kinase; transcription factor 4; polysaccharide; programmed death 1 ligand 1; cancer immunotherapy; cytotoxicity; ectopic expression; endocytosis; glycosylation; human; immunosuppressive treatment; lysosome; nonhuman; priority journal; protein protein interaction; Short Survey; treatment response; triple negative breast cancer; tumor microenvironment; tumor rejection; upregulation; immunotherapy; B7-H1 Antigen; Humans; Immunotherapy; Polysaccharides; Triple Negative Breast Neoplasms |
| Año: | 2018 |
| Volumen: | 33 |
| Número: | 2 |
| Página de inicio: | 155 |
| Página de fin: | 157 |
| DOI: | http://dx.doi.org/10.1016/j.ccell.2018.01.015 |
| Título revista: | Cancer Cell |
| Título revista abreviado: | Cancer Cell |
| ISSN: | 15356108 |
| CODEN: | CCAEC |
| CAS: | epidermal growth factor, 59459-45-9, 62229-50-9; glycogen synthase kinase, 9059-09-0; B7-H1 Antigen; Polysaccharides |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15356108_v33_n2_p155_Salatino |
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Citas:
---------- APA ----------
Salatino, M., Girotti, M.R. & Rabinovich, G.A. (2018) . Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer. Cancer Cell, 33(2), 155-157.http://dx.doi.org/10.1016/j.ccell.2018.01.015
---------- CHICAGO ----------
Salatino, M., Girotti, M.R., Rabinovich, G.A. "Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer" . Cancer Cell 33, no. 2 (2018) : 155-157.http://dx.doi.org/10.1016/j.ccell.2018.01.015
---------- MLA ----------
Salatino, M., Girotti, M.R., Rabinovich, G.A. "Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer" . Cancer Cell, vol. 33, no. 2, 2018, pp. 155-157.http://dx.doi.org/10.1016/j.ccell.2018.01.015
---------- VANCOUVER ----------
Salatino, M., Girotti, M.R., Rabinovich, G.A. Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer. Cancer Cell. 2018;33(2):155-157.http://dx.doi.org/10.1016/j.ccell.2018.01.015
