Artículo

Sabatini, S.E.; Rocchetta, I.; Nahabedian, D.E.; Luquet, C.M.; Eppis, M.R.; Bianchi, L.; Ríos De Molina, M.D.C. "Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis" (2011) Comparative Biochemistry and Physiology - C Toxicology and Pharmacology. 154(4):391-398
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Abstract:

The aim of this work was to study the oxidative stress effects and histological alterations caused by dietary copper on the filter-feeding freshwater mussel Diplodon chilensis. Bivalves were fed during 6 weeks with the green algae Scenedesmus vacuolatus previously exposed to copper. Metal concentration in algae cultures and bivalve digestive gland was measured by TXRF. A maximum accumulation of 0.49 μg Cu/mg protein was detected at week 6. Also at this week, the hepatosomatic index (HSI) showed the highest decrease (50%) in response to Cu exposure. SOD and GST activities were significantly increased at weeks 4, 5 and 6, reaching an activity on average 50% higher than in controls for GST. CAT activity and GSH increased significantly at weeks 5 and 6. Despite this response, oxidative damage measured as TBARS and carbonyl groups contents increased significantly at weeks 4, 5 and 6, respectively. Digestive tubule and duct atrophy and cell-type replacement in treated mussels were observed by histological studies. The presence of intracellular rhodanine-positive granules, suggests copper accumulation in intracellular vacuoles of digestive cells. © 2011 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis
Autor:Sabatini, S.E.; Rocchetta, I.; Nahabedian, D.E.; Luquet, C.M.; Eppis, M.R.; Bianchi, L.; Ríos De Molina, M.D.C.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428, Buenos Aires, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Rivadavia, 1917 Buenos Aires, Argentina
Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428, Buenos Aires, Argentina
Laboratorio de Ecotoxicología Acuática, INIBIOMA (CONICET-UNCo), Pasaje de la Paz 235 San Martín de los Andes, 8370, Neuquén, Argentina
U. A. Combustibles Nucleares, C.A.C. Comisión Nacional de Energía Atómica, Av. Gral. Paz 1499, 1650, Pcia, Buenos Aires, Argentina
Palabras clave:Antioxidant defenses; Dietary copper; Diplodon chilensis; Metal bioaccumulation; Oxidative stress; copper; fresh water; rhodanine; article; bivalve; Chlorophyceae; controlled study; dietary intake; exocrine gland; freshwater species; histology; nonhuman; oxidative stress; priority journal; Scenedesmus; Animals; Bivalvia; Catalase; Copper; Fresh Water; Glutathione; Lipid Peroxidation; Oxidative Stress; Scenedesmus; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; algae; Bivalvia; Chlorophyta; Diplodon chilensis; Scenedesmus vacuolatus
Año:2011
Volumen:154
Número:4
Página de inicio:391
Página de fin:398
DOI: http://dx.doi.org/10.1016/j.cbpc.2011.07.009
Título revista:Comparative Biochemistry and Physiology - C Toxicology and Pharmacology
Título revista abreviado:Comp. Biochem. Physiol. C Toxicol. Pharmacol.
ISSN:15320456
CODEN:CBPPF
CAS:copper, 15158-11-9, 7440-50-8; rhodanine, 141-84-4; Catalase, 1.11.1.6; Copper, 7440-50-8; Glutathione, 70-18-8; Superoxide Dismutase, 1.15.1.1; Thiobarbituric Acid Reactive Substances
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15320456_v154_n4_p391_Sabatini

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Citas:

---------- APA ----------
Sabatini, S.E., Rocchetta, I., Nahabedian, D.E., Luquet, C.M., Eppis, M.R., Bianchi, L. & Ríos De Molina, M.D.C. (2011) . Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis. Comparative Biochemistry and Physiology - C Toxicology and Pharmacology, 154(4), 391-398.
http://dx.doi.org/10.1016/j.cbpc.2011.07.009
---------- CHICAGO ----------
Sabatini, S.E., Rocchetta, I., Nahabedian, D.E., Luquet, C.M., Eppis, M.R., Bianchi, L., et al. "Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis" . Comparative Biochemistry and Physiology - C Toxicology and Pharmacology 154, no. 4 (2011) : 391-398.
http://dx.doi.org/10.1016/j.cbpc.2011.07.009
---------- MLA ----------
Sabatini, S.E., Rocchetta, I., Nahabedian, D.E., Luquet, C.M., Eppis, M.R., Bianchi, L., et al. "Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis" . Comparative Biochemistry and Physiology - C Toxicology and Pharmacology, vol. 154, no. 4, 2011, pp. 391-398.
http://dx.doi.org/10.1016/j.cbpc.2011.07.009
---------- VANCOUVER ----------
Sabatini, S.E., Rocchetta, I., Nahabedian, D.E., Luquet, C.M., Eppis, M.R., Bianchi, L., et al. Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2011;154(4):391-398.
http://dx.doi.org/10.1016/j.cbpc.2011.07.009