Artículo

Pinho, G.L.L.; Moura Da Rosa, C.; Yunes, J.S.; Luquet, C.M.; Bianchini, A.; Monserrat, J.M. "Toxic effects of microcystins in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Grapsidae)" (2003) Comparative Biochemistry and Physiology - C Toxicology and Pharmacology. 135(4):459-468
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Abstract:

Microcystins are toxins produced by cyanobacteria, being toxic to aquatic fauna. It was evaluated alternative mechanisms of microcystins toxicity, including oxidative stress and histopathology in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Grapsidae). Microcystins was administered to crabs (MIC group) over 1 week, whereas the control (CTR group) received the saline from cyanobacteria culture medium. At day 7, catalase activity was higher in the MIC than in the CTR group, although a decrease of activity was verified in both groups with respect to time 0. Glutathione-S-transferase activity augmented in MIC with respect to CTR, suggesting a higher conjugation rate of the toxins with glutathione. No differences were detected in the superoxide dismutase activity. Lipid peroxidation remained stable in both groups. Histopathological analyses showed that the number of B cells decreased significantly in the CTR as a possible effect of starvation, while no significant change was observed in the MIC group. The hepatopancreas from the MIC group exhibited some necrotic tubules and melanin-like deposits. Overall, results showed that some enzymes of the antioxidant defense system were activated after microcystins exposure, this response being able to maintain lipid peroxidation levels, but insufficient to completely prevent histological damage. © 2003 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Toxic effects of microcystins in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Grapsidae)
Autor:Pinho, G.L.L.; Moura Da Rosa, C.; Yunes, J.S.; Luquet, C.M.; Bianchini, A.; Monserrat, J.M.
Filiación:Depto. de Cie. Fisiológicas, Fund. Univ. Federal Do Rio Grande, R. Eng Alfredo Huch 475, Rio Grande 96201-900, Brazil
Programa de Pós, Graduacao Em Cie. Fisologicas, Fisiologia Animal Comparada, Brazil
Unidade Pesquisa Em Cianobacterias, Fund. Univ. Federal Do Rio Grande, Rio Grande 96201-900, Brazil
Laboratório de Histologia, Fac. de Ciencias Exactas Y Naturales, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
Palabras clave:B cells; Catalase; Chasmagnathus granulatus; Estuarine crab; Glutathione-S-transferase; Histopathology; Microcystins; Oxidative stress; catalase; cyanoginosin; glutathione transferase; superoxide dismutase; animal experiment; animal model; animal tissue; article; B lymphocyte; controlled study; crab; enzyme activity; hepatopancreas; histopathology; lipid peroxidation; liver toxicity; lymphocyte count; male; minimum inhibitory concentration; nonhuman; oxidative stress; priority journal; Animals; Bacterial Toxins; Catalase; Cyanobacteria; Decapoda (Crustacea); Glutathione Transferase; Hepatopancreas; Histocytochemistry; Lipid Peroxides; Male; Melanins; Microcystins; Necrosis; Oxidative Stress; Peptides, Cyclic; Superoxide Dismutase; Chasmagnathus granulata; Cyanobacteria; Decapoda (Crustacea); Grapsidae
Año:2003
Volumen:135
Número:4
Página de inicio:459
Página de fin:468
DOI: http://dx.doi.org/10.1016/S1532-0456(03)00147-9
Título revista:Comparative Biochemistry and Physiology - C Toxicology and Pharmacology
Título revista abreviado:Comp. Biochem. Physiol. C Toxicol. Pharmacol.
ISSN:15320456
CODEN:CBPPF
CAS:catalase, 9001-05-2; glutathione transferase, 50812-37-8; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; Bacterial Toxins; Catalase, EC 1.11.1.6; Glutathione Transferase, EC 2.5.1.18; Lipid Peroxides; Melanins; microcystin, 77238-39-2; Microcystins; Peptides, Cyclic; Superoxide Dismutase, EC 1.15.1.1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15320456_v135_n4_p459_Pinho

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Citas:

---------- APA ----------
Pinho, G.L.L., Moura Da Rosa, C., Yunes, J.S., Luquet, C.M., Bianchini, A. & Monserrat, J.M. (2003) . Toxic effects of microcystins in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Grapsidae). Comparative Biochemistry and Physiology - C Toxicology and Pharmacology, 135(4), 459-468.
http://dx.doi.org/10.1016/S1532-0456(03)00147-9
---------- CHICAGO ----------
Pinho, G.L.L., Moura Da Rosa, C., Yunes, J.S., Luquet, C.M., Bianchini, A., Monserrat, J.M. "Toxic effects of microcystins in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Grapsidae)" . Comparative Biochemistry and Physiology - C Toxicology and Pharmacology 135, no. 4 (2003) : 459-468.
http://dx.doi.org/10.1016/S1532-0456(03)00147-9
---------- MLA ----------
Pinho, G.L.L., Moura Da Rosa, C., Yunes, J.S., Luquet, C.M., Bianchini, A., Monserrat, J.M. "Toxic effects of microcystins in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Grapsidae)" . Comparative Biochemistry and Physiology - C Toxicology and Pharmacology, vol. 135, no. 4, 2003, pp. 459-468.
http://dx.doi.org/10.1016/S1532-0456(03)00147-9
---------- VANCOUVER ----------
Pinho, G.L.L., Moura Da Rosa, C., Yunes, J.S., Luquet, C.M., Bianchini, A., Monserrat, J.M. Toxic effects of microcystins in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Grapsidae). Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2003;135(4):459-468.
http://dx.doi.org/10.1016/S1532-0456(03)00147-9