Artículo

Cochón, A.C.; San Martín De Viale, L.C.; Billi De Catabbi, S.C. "Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent" (2001) Comparative Biochemistry and Physiology - C Toxicology and Pharmacology. 130(2):199-207
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Abstract:

Hexachlorobenzene (HCB) alters phospholipid and heme metabolisms in the liver and Harderian gland. The effects of HCB on phospholipid metabolism, in an organ considered to be non-responsive to its porphyrinogenic effects, remain to be studied. Therefore, as the brain is an organ with this feature, this paper analyzes the effects of HCB on brain phospholipid composition in order to investigate if there is any relationship between HCB-induced porphyrin metabolism disruption and phospholipid alterations. For this purpose, a time-course study of HCB effects on brain phospholipids was performed in two strains of rats differing in their susceptibility to acquire hepatic porphyria: Chbb THOM (low); and Wistar (high). This paper shows for the first time that rat brain phospholipids are affected by HCB exposure. Comparative studies show that HCB-induced disturbances in brain phospholipid patterns are time and strain-dependent. Thus, whereas major phospholipids, phosphatidylcholine and phosphatidylethanolamine were more altered in Wistar rats, minor phospholipids, phosphatidylinositol and phosphatidylserine were more affected in Chbb THOM rats. HCB intoxication led to a sphingomyelin/phosphatidylcholine molar ratio lower than the normal, in both strains. As was expected, brain porphyrin content was not altered by HCB intoxication in either strain. It can be concluded that HCB is able to alter brain phospholipid metabolism in a strain-dependent fashion, and in the absence of alterations in brain heme metabolism. In addition, HCB-induced disturbances in brain phospholipids were not related to the degree of hepatic porphyria achieved by the rats. © 2001 Elsevier Science Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent
Autor:Cochón, A.C.; San Martín De Viale, L.C.; Billi De Catabbi, S.C.
Filiación:Laboratorio De Porfirias Experimentales Y Metabolismo del Hemo, Departamento De Química Biológica, Ciudad Universitaria, Nuñez, 1428, Buenos Aires, Argentina
O'Higgins 4332, Cap. Fed. 1429, Buenos Aires, Argentina
Palabras clave:Brain; Hexachlorobenzene; Phospholipid; Porphyria; Porphyrin; Rat; heme; hexachlorobenzene; phosphatidylcholine; phosphatidylethanolamine; phosphatidylinositol; phosphatidylserine; phospholipid; porphyrin; sphingomyelin; animal experiment; animal model; animal tissue; article; brain level; concentration response; controlled study; disease severity; female; hepatic porphyria; intoxication; lipid composition; metabolic disorder; nonhuman; phospholipid metabolism; porphyrin metabolism; priority journal; rat; strain difference; time; Animals; Brain; Female; Hexachlorobenzene; Organ Size; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Phospholipids; Porphyrias; Porphyrins; Rats; Rats, Wistar; Species Specificity; Sphingomyelins
Año:2001
Volumen:130
Número:2
Página de inicio:199
Página de fin:207
DOI: http://dx.doi.org/10.1016/S1532-0456(01)00240-X
Título revista:Comparative Biochemistry and Physiology - C Toxicology and Pharmacology
Título revista abreviado:Comp. Biochem. Physiol. C Toxicol. Pharmacol.
ISSN:15320456
CODEN:CBPPF
CAS:Hexachlorobenzene, 118-74-1; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Phospholipids; Porphyrins; Sphingomyelins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15320456_v130_n2_p199_Cochon

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Citas:

---------- APA ----------
Cochón, A.C., San Martín De Viale, L.C. & Billi De Catabbi, S.C. (2001) . Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent. Comparative Biochemistry and Physiology - C Toxicology and Pharmacology, 130(2), 199-207.
http://dx.doi.org/10.1016/S1532-0456(01)00240-X
---------- CHICAGO ----------
Cochón, A.C., San Martín De Viale, L.C., Billi De Catabbi, S.C. "Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent" . Comparative Biochemistry and Physiology - C Toxicology and Pharmacology 130, no. 2 (2001) : 199-207.
http://dx.doi.org/10.1016/S1532-0456(01)00240-X
---------- MLA ----------
Cochón, A.C., San Martín De Viale, L.C., Billi De Catabbi, S.C. "Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent" . Comparative Biochemistry and Physiology - C Toxicology and Pharmacology, vol. 130, no. 2, 2001, pp. 199-207.
http://dx.doi.org/10.1016/S1532-0456(01)00240-X
---------- VANCOUVER ----------
Cochón, A.C., San Martín De Viale, L.C., Billi De Catabbi, S.C. Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2001;130(2):199-207.
http://dx.doi.org/10.1016/S1532-0456(01)00240-X