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Abstract:

Hyaluronic acid (HA) hydrogels were structured in the form of porous monoliths by means of the ice-segregation-induced self-assembly (ISISA) method coupled with freeze-drying. Physical and chemical parameters were explored in order to fine-tune the microstructure and the incidence on both swelling and dissolution behavior in aqueous media. Gentamicin-loaded HA matrices with tuned drug release properties were also prepared; their inherent properties and behavior in solution are discussed in the framework of thermal analysis and scanning electron microscopy inspection. © 2012 American Chemical Society.

Registro:

Documento: Artículo
Título:Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties
Autor:Minaberry, Y.; Chiappetta, D.A.; Sosnik, A.; Jobbágy, M.
Filiación:INQUIMAE-DQIAQF, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pab. II, C1428EHA, Buenos Aires, Argentina
Group of Biomaterials and Nanotechnology for Improved Medicines (BIONIMED), Department of Pharmaceutical Technology, University of Buenos Aires, Buenos Aires, Argentina
National Science Research Council (CONICET), Argentina
Centro Interdisciplinario de Nanociencia y Nanotecnología, Argentina
Palabras clave:Aqueous media; Dissolution behavior; Drug release properties; Hyaluronic acids; Physical and chemical parameters; Porous monoliths; Scanning electron microscopy; Thermoanalysis; Organic acids; gentamicin; hyaluronic acid; article; chemical structure; drug release; extracellular matrix; freeze drying; hydrogel; physical parameters; priority journal; scanning electron microscopy; thermal analysis; tuned swelling; Drug Carriers; Gentamicins; Hyaluronic Acid; Hydrogels; Microspheres; Nanostructures
Año:2013
Volumen:14
Número:1
Página de inicio:1
Página de fin:9
DOI: http://dx.doi.org/10.1021/bm300814h
Título revista:Biomacromolecules
Título revista abreviado:Biomacromolecules
ISSN:15257797
CODEN:BOMAF
CAS:gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; hyaluronic acid, 31799-91-4, 9004-61-9, 9067-32-7; Drug Carriers; Gentamicins; Hyaluronic Acid, 9004-61-9; Hydrogels
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15257797_v14_n1_p1_Minaberry

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Citas:

---------- APA ----------
Minaberry, Y., Chiappetta, D.A., Sosnik, A. & Jobbágy, M. (2013) . Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties. Biomacromolecules, 14(1), 1-9.
http://dx.doi.org/10.1021/bm300814h
---------- CHICAGO ----------
Minaberry, Y., Chiappetta, D.A., Sosnik, A., Jobbágy, M. "Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties" . Biomacromolecules 14, no. 1 (2013) : 1-9.
http://dx.doi.org/10.1021/bm300814h
---------- MLA ----------
Minaberry, Y., Chiappetta, D.A., Sosnik, A., Jobbágy, M. "Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties" . Biomacromolecules, vol. 14, no. 1, 2013, pp. 1-9.
http://dx.doi.org/10.1021/bm300814h
---------- VANCOUVER ----------
Minaberry, Y., Chiappetta, D.A., Sosnik, A., Jobbágy, M. Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties. Biomacromolecules. 2013;14(1):1-9.
http://dx.doi.org/10.1021/bm300814h