Navegar

Colección

Datos Estadísticas

Artículo

Petroni, A.; Deluchi, G.; Pryluka, D.; Rotryng, F.; Bortolozzi, R.; Lopardo, G.; Bouzas, M.B.; Zapiola, I.; Garone, D.; Rodríguez, C.; Chiocconi, E.; Lázaro, M.E.; Murano, F.; Maranzana, A.; Oliva, S.M.; Aparicio, M.; Beltrán, M.; Benetucci, J.A. "Update on primary HIV-1 resistance in Argentina: Emergence of mutations conferring high-level resistance to nonnucleoside reverse transcriptase inhibitors in drug-naive patients" (2006) Journal of Acquired Immune Deficiency Syndromes. 42(4):506-510
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Here we present a survey including 52 drug-naive recently HIV-1-infected subjects from Buenos Aires City and province (79%) and 3 other regions in Argentina (21%). Recent infections were established from previous negative serology (32/52), indeterminate Western blot (12/52), or acute retroviral syndrome after high-risk HIV exposure (8/52) within 9 months before genotyping (median time, 4.2 months). Genotyping was performed from plasma by sequencing both protease and reverse transcriptase. Phylogenetic analysis combined with bootscanning resulted in 21 subtype B sequences and 31 B/F recombinants (RecBF). On protease, minor resistance-related mutations were found in both subtype B and RecBF with low frequencies. The substitution L89M, recently suggested as a resistance-related mutation in some subtype F viruses, was observed in 1 RecBF. On reverse transcriptase, major resistance-related mutations were found in 4 of 52 (7.7%) patients from different health centers: M41L (subtype B) and K103N±P225H (1 RecBF and 2 subtype B). The greater than 5% resistance threshold found indicates a need for sentinel resistance surveillances calling for an update in the current resistance testing guidelines in Argentina. Copyright © 2006 by Lippincott Williams & Wilkins.

Registro:

Documento: Artículo
Título:Update on primary HIV-1 resistance in Argentina: Emergence of mutations conferring high-level resistance to nonnucleoside reverse transcriptase inhibitors in drug-naive patients
Autor:Petroni, A.; Deluchi, G.; Pryluka, D.; Rotryng, F.; Bortolozzi, R.; Lopardo, G.; Bouzas, M.B.; Zapiola, I.; Garone, D.; Rodríguez, C.; Chiocconi, E.; Lázaro, M.E.; Murano, F.; Maranzana, A.; Oliva, S.M.; Aparicio, M.; Beltrán, M.; Benetucci, J.A.
Filiación:Fundación de Ayuda Al Inmunodeficiente, Buenos Aires, Argentina
Centro Medicus, Buenos Aires, Argentina
Hospital Juan Bautista Alberdi, Rosario, Provincia de Santa Fe, Argentina
Centro de Estudios Infectológicos, Buenos Aires, Argentina
Unidad de Virología, Hospital Muñiz, Buenos Aires, Argentina
Hospital Houssay, Vicente López, Argentina
Hospital Cosme Argerich, Buenos Aires, Argentina
Hospital Provincial de Neuquén, Provincia de Neuquén, Argentina
Hospital Zonal de Bariloche, Provincia de Río Negro, Argentina
Hospital Cordero, San Fernando, Argentina
Hospital Muñiz, Buenos Aires, Argentina
Hospital Artémides Zatti, Viedma, Argentina
Hospital Municipal de San Isidro, Provincia de Buenos Aires, Argentina
Laboratorio de Retrovirus Y Virus Asociados, Hospital Muñiz, Pabellón de FUNDAI, Uspallata 2272, (C1282AEN), Buenos Aires, Argentina
Palabras clave:Argentina; B/F recombinant viruses; HIV-1 primary resistance; K103N; L89M; M41L; proteinase; recombinant enzyme; RNA directed DNA polymerase; RNA directed DNA polymerase inhibitor; adult; amino acid sequence; amino acid substitution; Argentina; controlled study; exposure; female; gene mutation; genotype; health survey; high risk population; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; major clinical study; male; nucleotide sequence; phylogeny; priority journal; review; serology; virus resistance; Western blotting; Argentina; Base Sequence; DNA Primers; Female; HIV Infections; HIV-1; Humans; Male; Mutation; Phylogeny; Polymorphism, Genetic; Recombination, Genetic; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction
Año:2006
Volumen:42
Número:4
Página de inicio:506
Página de fin:510
DOI: http://dx.doi.org/10.1097/01.qai.0000222285.44460.e2
Título revista:Journal of Acquired Immune Deficiency Syndromes
Título revista abreviado:J. Acquired Immune Defic. Syndr.
ISSN:15254135
CODEN:JJASF
CAS:proteinase, 9001-92-7; RNA directed DNA polymerase, 37213-50-6, 9068-38-6; DNA Primers; Reverse Transcriptase Inhibitors
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15254135_v42_n4_p506_Petroni

Referencias:

  • Weinstock, H.S., Zaidi, I., Heneine, W., The epidemiology of antiretroviral drug resistance among drug-naive HIV-1-infected persons in 10 US cities (2004) J Infect Dis, 189, pp. 2174-2180
  • Soares, M.A., Brindeiro, R.M., Tanuri, A., Primary HIV-1 drug resistance in Brazil (2004) AIDS, 18 (3 SUPPL.), pp. S9-S13
  • Wensing, A.M.J., Van De Vijver, D.A., Angarano, G., Prevalence of drug-resistant HIV-1 variants in untreated individuals in Europe: Implications for clinical management (2005) J Infect Dis, 192, pp. 958-966
  • (2005) Boletín Sobre El VIH/SIDA en la Argentina, 24. , http://www.msal.gov.ar/htm/site/sida/site/datos-epid-boletines.asp, Programa Nacional de Lucha contra los Retrovirus del Humano, SIDA y ETS
  • Kijak, G.H., Pampuro, S.E., Avila, M.M., Resistance profiles to antiretroviral drugs in HIV-1 drug-naive patients in Argentina (2001) Antivir Ther, 6, pp. 71-77
  • (2003) Guidelines for Surveillance of HIV Drug Resistance, , http://www.phppo.cdc.gov/dls/ila/cd/who-afro/resisguide12_12.pdf
  • Masciotra, S., Livellara, B., Belloso, W., Evidence of a high frequency of HIV-1 subtype F infections in a heterosexual population in Buenos Aires, Argentina (2000) AIDS Res Hum Retroviruses, 16, pp. 1007-1014
  • Thomson, M.M., Villahermosa, M.L., Vázquez-de-Parga, E., Widespread circulation of a B/F intersubtype recombinant form among HIV-1-infected individuals in Buenos Aires, Argentina (2000) AIDS, 14, pp. 897-899
  • Avila, M.M., Pando, M.A., Carrion, G., Two HIV-1 epidemics in Argentina: Different genetic subtypes associated with different risk groups (2002) J Acquir Immune Defic Syndr, 29, pp. 422-426
  • Petroni, A., Deluchi, G., Zanotto, P., B/F intersubtype recombinants of HIV-1 in Argentina: Impact on genotypic patterns associated with antiretroviral drug resistance [693] (2004) 11th Conference on Retroviruses and Opportunistic Infections, , San Francisco, CA
  • Espinosa, A., Vignoles, M., Gómez Carrillo, M., Intersubtype BF recombinants of HIV-1 in a population of injecting drug users in Argentina (2004) J Acquir Immune Defic Syndr, 36, pp. 630-636
  • Quarleri, J.F., Rubio, A., Carobene, M., HIV type 1 BF recombinant strains exhibit different pol gene mosaic patterns: Descriptive analysis from 284 patients under treatment failure (2004) AIDS Res Hum Retroviruses, 20, pp. 1100-1107
  • Carr, J.K., Avila, M., Gomez Carrillo, M., Diverse BF recombinants have spread widely since the introduction of HIV-1 into South America (2001) AIDS, 15, pp. F41-F47
  • Thomson, M.M., Delgado, E., Herrero, I., Diversity of mosaic structures and common ancestry of human immunodeficiency virus type 1 BF intersubtype recombinant viruses from Argentina revealed by analysis of near full-length genome sequences (2002) J Gen Virol, 83, pp. 107-119
  • Johnson, V.A., Brun-Vézinet, F., Clotet, B., Update of the drug resistance mutations in HIV-1: 2005 (2005) Top HIV Med, 13, pp. 51-57
  • Calazans, A., Brindeiro, R., Brindeiro, P., Low accumulation of L90M in protease from subtype F HIV-1 with resistance to protease inhibitors is caused by the L89M polymorphism (2005) J Infect Dis, 191, pp. 1961-1970
  • Dilernia, D.A., Lourtau, L., Marone, R., Prevalence of drug-resistance associated mutations among newly diagnosed HIV-1 infected individuals at two voluntary testing centers in the city of Buenos Aires, Argentina [WePe4.1C14] (2005) 3rd IAS Conference on HIV Pathogenesis and Treatment, , Rio de Janeiro, Brazil
  • De Mendoza, C., Rodríguez, C., Colomina, J., Resistance to nonnucleoside reverse-transcriptase inhibitors and prevalence of HIV type 1 non-B subtypes are increasing among persons with recent infection in Spain (2005) Clin Infect Dis, 41, pp. 1350-1354

Citas:

---------- APA ----------
Petroni, A., Deluchi, G., Pryluka, D., Rotryng, F., Bortolozzi, R., Lopardo, G., Bouzas, M.B.,..., Benetucci, J.A. (2006) . Update on primary HIV-1 resistance in Argentina: Emergence of mutations conferring high-level resistance to nonnucleoside reverse transcriptase inhibitors in drug-naive patients. Journal of Acquired Immune Deficiency Syndromes, 42(4), 506-510.
http://dx.doi.org/10.1097/01.qai.0000222285.44460.e2
---------- CHICAGO ----------
Petroni, A., Deluchi, G., Pryluka, D., Rotryng, F., Bortolozzi, R., Lopardo, G., et al. "Update on primary HIV-1 resistance in Argentina: Emergence of mutations conferring high-level resistance to nonnucleoside reverse transcriptase inhibitors in drug-naive patients" . Journal of Acquired Immune Deficiency Syndromes 42, no. 4 (2006) : 506-510.
http://dx.doi.org/10.1097/01.qai.0000222285.44460.e2
---------- MLA ----------
Petroni, A., Deluchi, G., Pryluka, D., Rotryng, F., Bortolozzi, R., Lopardo, G., et al. "Update on primary HIV-1 resistance in Argentina: Emergence of mutations conferring high-level resistance to nonnucleoside reverse transcriptase inhibitors in drug-naive patients" . Journal of Acquired Immune Deficiency Syndromes, vol. 42, no. 4, 2006, pp. 506-510.
http://dx.doi.org/10.1097/01.qai.0000222285.44460.e2
---------- VANCOUVER ----------
Petroni, A., Deluchi, G., Pryluka, D., Rotryng, F., Bortolozzi, R., Lopardo, G., et al. Update on primary HIV-1 resistance in Argentina: Emergence of mutations conferring high-level resistance to nonnucleoside reverse transcriptase inhibitors in drug-naive patients. J. Acquired Immune Defic. Syndr. 2006;42(4):506-510.
http://dx.doi.org/10.1097/01.qai.0000222285.44460.e2