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Abstract:

The non-obese diabetic (NOD) mouse model of autoimmune sialadenitis offers the possibility of studying the L-arginine/nitric oxide signaling pathway in salivary glands in basal and neurotransmitter-stimulated conditions and, thus, of analyzing the neural control of the secretory process in the target organ. The purpose of this study was to explore putative alterations in the activity and expression of nitric oxide synthase (NOS) in submandibular glands of NOD mice in relation to parotid glands and unrelated tissues. Here we report that NOD mice with incipient signs of secretory dysfunction presented a marked decrease in basal and vasoactive intestinal peptide (VIP)-stimulated NOS activity and a differential expression of NOS I in submandibular glands compared to control BALB/c mice. Similar alterations in NOS I were found in parotid glands but not in brain or spleen of NOD mice. No differences between NOD and controls appeared in NOS II and NOS III expression in any of the tissues studied. © 2001 Academic Press.

Registro:

Documento: Artículo
Título:Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice
Autor:Rosignoli, F.; Goren, N.B.; Pérez Leirós, C.
Filiación:Departamento De Química Biológica, Facultad De Ciencias Exactas Y Naturales, Universidad De Buenos Aires-CONICET, Buenos Aires, Argentina
Facultad De Ciencias Exactas Y Naturales, Universidad De Buenos Aires-CONICET, Centro De Estudios Farmacológicos Y Botánicos-CONICET, Buenos Aires, Argentina
Palabras clave:Autoimmune sialadenitis; Nitric oxide synthase; NOD; NOS isoforms; Salivary glands; VIP; autoantibody; nitric oxide synthase; animal experiment; animal model; article; autoimmunity; controlled study; enzyme activity; flow rate; inflammatory cell; lymphocyte proliferation; mouse; neurotransmitter release; nonhuman; priority journal; salivation; sialoadenitis; Sjoegren syndrome; submandibular gland; target cell; translation regulation
Año:2001
Volumen:101
Número:1
Página de inicio:86
Página de fin:93
DOI: http://dx.doi.org/10.1006/clim.2001.5097
Título revista:Clinical Immunology
Título revista abreviado:Clin. Immunol.
ISSN:15216616
CODEN:CLIIF
CAS:nitric oxide synthase, 125978-95-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15216616_v101_n1_p86_Rosignoli

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Citas:

---------- APA ----------
Rosignoli, F., Goren, N.B. & Pérez Leirós, C. (2001) . Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice. Clinical Immunology, 101(1), 86-93.
http://dx.doi.org/10.1006/clim.2001.5097
---------- CHICAGO ----------
Rosignoli, F., Goren, N.B., Pérez Leirós, C. "Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice" . Clinical Immunology 101, no. 1 (2001) : 86-93.
http://dx.doi.org/10.1006/clim.2001.5097
---------- MLA ----------
Rosignoli, F., Goren, N.B., Pérez Leirós, C. "Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice" . Clinical Immunology, vol. 101, no. 1, 2001, pp. 86-93.
http://dx.doi.org/10.1006/clim.2001.5097
---------- VANCOUVER ----------
Rosignoli, F., Goren, N.B., Pérez Leirós, C. Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice. Clin. Immunol. 2001;101(1):86-93.
http://dx.doi.org/10.1006/clim.2001.5097