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Abstract:

Galectins are a family of evolutionarily conserved animal lectins with pleiotropic functions and widespread distribution. Fifteen members have been identified in a wide variety of cells and tissues. Through recognition of cell surface glycoproteins and glycolipids, these endogenous lectins can trigger a cascade of intracellular signaling pathways capable of modulating cell differentiation, proliferation, survival, and migration. These cellular events are critical in a variety of biological processes including embryogenesis, angiogenesis, neurogenesis, and immunity and are substantially altered during tumorigenesis, neurodegeneration, and inflammation. In addition, galectins can modulate intracellular functions and this effect involves direct interactions with distinct signaling pathways. In this review, we discuss current knowledge on the intracellular signaling pathways triggered by this multifunctional family of β-galactoside-binding proteins in selected physiological and pathological settings. Understanding the "galectin signalosome" will be essential to delineate rational therapeutic strategies based on the specific control of galectin expression and function. © 2009 IUBMB.

Registro:

Documento: Artículo
Título:Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings
Autor:Laderach, D.J.; Compagno, D.; Toscano, M.A.; Croci, D.O.; Dergan-Dylon, S.; Salatino, M.; Rabinovich, G.A.
Filiación:Facultad de Ciencias Exactas Y Naturales, Departamento de Química Biológica, Universidad de Buenos Aires, Buenos Aires C1428, Argentina
Laboratorio de Inmunopatología, Instituto de Biología Y Medicina Experimental, Consejo Nacional de Investigaciones Científicas Y Técnicas, Buenos Aires C1428, Argentina
Palabras clave:Apoptosis; Differentiation; Galectins; Immune regulation; Oncogenesis; Signaling pathways; galaptin; galectin; glycan; galectin; polysaccharide; cell adhesion; cell differentiation; cell proliferation; cell transformation; connective tissue; embryo development; hematopoietic system; nervous tissue; protein expression; protein function; protein interaction; review; signal transduction; tumor cell; animal; hematopoiesis; human; metabolism; neoplasm; pathophysiology; physiology; signal transduction; Animalia; Animals; Galectins; Hematopoiesis; Humans; Neoplasms; Polysaccharides; Signal Transduction
Año:2010
Volumen:62
Número:1
Página de inicio:1
Página de fin:13
DOI: http://dx.doi.org/10.1002/iub.281
Título revista:IUBMB Life
Título revista abreviado:IUBMB Life
ISSN:15216543
CODEN:IULIF
CAS:galaptin, 118251-01-7; Galectins; Polysaccharides
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_15216543_v62_n1_p1_Laderach.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15216543_v62_n1_p1_Laderach

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Citas:

---------- APA ----------
Laderach, D.J., Compagno, D., Toscano, M.A., Croci, D.O., Dergan-Dylon, S., Salatino, M. & Rabinovich, G.A. (2010) . Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings. IUBMB Life, 62(1), 1-13.
http://dx.doi.org/10.1002/iub.281
---------- CHICAGO ----------
Laderach, D.J., Compagno, D., Toscano, M.A., Croci, D.O., Dergan-Dylon, S., Salatino, M., et al. "Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings" . IUBMB Life 62, no. 1 (2010) : 1-13.
http://dx.doi.org/10.1002/iub.281
---------- MLA ----------
Laderach, D.J., Compagno, D., Toscano, M.A., Croci, D.O., Dergan-Dylon, S., Salatino, M., et al. "Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings" . IUBMB Life, vol. 62, no. 1, 2010, pp. 1-13.
http://dx.doi.org/10.1002/iub.281
---------- VANCOUVER ----------
Laderach, D.J., Compagno, D., Toscano, M.A., Croci, D.O., Dergan-Dylon, S., Salatino, M., et al. Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings. IUBMB Life. 2010;62(1):1-13.
http://dx.doi.org/10.1002/iub.281