Artículo

Cánepa, E.T.; Scassa, M.E.; Ceruti, J.M.; Marazita, M.C.; Carcagno, A.L.; Sirkin, P.F.; Ogara, M.F. "INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions" (2007) IUBMB Life. 59(7):419-426
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Abstract:

The cyclin D-Cdk4-6/INK4/Rb/E2F pathway plays a key role in controlling cell growth by integrating multiple mitogenic and antimitogenic stimuli. The members of INK4 family, comprising p16INK4a, p15INK4b, p18INK4c, and p19INK4d, block the progression of the cell cycle by binding to either Cdk4 or Cdk6 and inhibiting the action of cyclin D. These INK4 proteins share a similar structure dominated by several ankyrin repeats. Although they appear to be structurally redundant and equally potent as inhibitors, the INK4 family members are differentially expressed during mouse development. The striking diversity in the pattern of expression of INK4 genes suggested that this family of cell cycle inhibitors might have cell lineage-specific or tissue-specific functions. The INK4 proteins are commonly lost or inactivated by mutations in diverse types of cancer, and they represent established or candidate tumor suppressors. Apart from their capacity to arrest cells in the G1-phase of the cell cycle they have been shown to participate in an increasing number of cellular processes. Given their emerging roles in fundamental physiological as well as pathological processes, it is interesting to explore the diverse roles for the individual INK4 family members in different functions other than cell cycle regulation. Extensive studies, over the past few years, uncover the involvement of INK4 proteins in senescence, apoptosis, DNA repair, and multistep oncogenesis. We will focus the discussion here on these unexpected issues. © 2007 IUBMB.

Registro:

Documento: Artículo
Título:INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
Autor:Cánepa, E.T.; Scassa, M.E.; Ceruti, J.M.; Marazita, M.C.; Carcagno, A.L.; Sirkin, P.F.; Ogara, M.F.
Filiación:Laboratorio de Biología Molecular, Departamento de Química Biológica, Universidad de Buenos Aires, Argentina
Laboratorio de Biología Molecular, Departamento de Química Biológica, Universidad de Buenos Aires, 1428 Ciudad de Buenos Aires, Argentina
Palabras clave:Apoptosis; Cancer; Cell cycle; DNA repair; INK4; Senescence; ankyrin; cyclin D; cyclin dependent kinase 4; cyclin dependent kinase 6; cyclin dependent kinase inhibitor 2B; cyclin dependent kinase inhibitor 2C; cyclin dependent kinase inhibitor 2D; protein p16INK4a; scleroprotein; transcription factor E2F1; apoptosis; carcinogenesis; cell cycle arrest; cell cycle G1 phase; cell cycle regulation; cell growth; cell lineage; DNA repair; genetic variability; human; mitogenesis; nonhuman; protein binding; protein expression; protein function; protein structure; review; senescence; tissue specificity; tumor suppressor gene; Animals; Apoptosis; Cell Aging; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor Proteins; DNA Repair; Humans; Multigene Family; Mammalia
Año:2007
Volumen:59
Número:7
Página de inicio:419
Página de fin:426
DOI: http://dx.doi.org/10.1080/15216540701488358
Título revista:IUBMB Life
Título revista abreviado:IUBMB Life
ISSN:15216543
CODEN:IULIF
CAS:cyclin D, 146587-97-5; cyclin dependent kinase 4, 147014-97-9; Cyclin-Dependent Kinase 4, EC 2.7.1.37; Cyclin-Dependent Kinase Inhibitor Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15216543_v59_n7_p419_Canepa

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Citas:

---------- APA ----------
Cánepa, E.T., Scassa, M.E., Ceruti, J.M., Marazita, M.C., Carcagno, A.L., Sirkin, P.F. & Ogara, M.F. (2007) . INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions. IUBMB Life, 59(7), 419-426.
http://dx.doi.org/10.1080/15216540701488358
---------- CHICAGO ----------
Cánepa, E.T., Scassa, M.E., Ceruti, J.M., Marazita, M.C., Carcagno, A.L., Sirkin, P.F., et al. "INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions" . IUBMB Life 59, no. 7 (2007) : 419-426.
http://dx.doi.org/10.1080/15216540701488358
---------- MLA ----------
Cánepa, E.T., Scassa, M.E., Ceruti, J.M., Marazita, M.C., Carcagno, A.L., Sirkin, P.F., et al. "INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions" . IUBMB Life, vol. 59, no. 7, 2007, pp. 419-426.
http://dx.doi.org/10.1080/15216540701488358
---------- VANCOUVER ----------
Cánepa, E.T., Scassa, M.E., Ceruti, J.M., Marazita, M.C., Carcagno, A.L., Sirkin, P.F., et al. INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions. IUBMB Life. 2007;59(7):419-426.
http://dx.doi.org/10.1080/15216540701488358