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Abstract:

Cytokines regulate many cellular responses such as proliferation, differentiation and survival and play regulatory roles in numerous organ systems. The cytokines of the IL-6 family use the membrane glycoprotein gp130 as a signal transducer and signal through the JAK/STAT pathway. As they share a common signal transducer they show some functional redundancy but also exhibit specific biological activities. Considering that gp130 is ubiquitously expressed, the time and place at which gp130 functions in vivo appears to be determined by spatially and chronologically regulated expression of specific cytokine-binding receptor chains or cytokines themselves. The study of transgenic and knock-out mice for different members of the gp130 signaling cascade has revealed they are critical in embryo development and play a role in physiological responses as diverse as hematopoiesis, the inflammatory response, nervous system development and survival and myocardial and pituitary proliferation. gp130 cytokines have also been implicated in cellular transformation and the pathophysiology of many tumors. Recently, two new families of proteins that function as negative regulators of cytokine signaling, SOCS and PIAS, have been extensively studied and could be new targets for the treatment of pathologies originated by gp130 signaling disregulation. The ubiquitin-proteosome pathway and the new ubiquitin-like protein SUMO-1 seem to play an important role in SOCS and PIAS mediated inhibition but the mechanisms still remain to be elucidated.

Registro:

Documento: Artículo
Título:Intracellular Proteins and Mechanisms Involved in the Control of gp130/JAK/STAT Cytokine Signaling
Autor:Carbia-Nagashima, A.; Arzt, E.
Filiación:Depto. de Fisiol./Biol. Molec./Cel., Fac. de Cie. Exact. y Nat. (FCEN), Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Cytokine; gp130; JAK; PIAS; SOCS; STAT; cell protein; cytokine; cytokine receptor; glycoprotein gp 130; interleukin 6; Janus kinase; proteasome; protein inhibitor of activated STAT; STAT protein; SUMO 1 protein; suppressor of cytokine signaling; ubiquitin; unclassified drug; animal cell; cell differentiation; cell proliferation; cell survival; cell transformation; embryo development; heart muscle cell; hematopoiesis; human; human cell; hypophysis cell; inflammation; knockout mouse; nervous system development; nonhuman; protein expression; protein family; protein function; regulatory mechanism; review; signal transduction; transgenic mouse; tumor; Animals; Cytokines; DNA-Binding Proteins; Humans; Neural Cell Adhesion Molecules; Protein-Tyrosine Kinases; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Animalia; Janus; Mus musculus
Año:2004
Volumen:56
Número:2
Página de inicio:83
Página de fin:88
DOI: http://dx.doi.org/10.1080/15216540410001668064
Título revista:IUBMB Life
Título revista abreviado:IUBMB Life
ISSN:15216543
CODEN:IULIF
CAS:Janus kinase, 161384-16-3; proteasome, 140879-24-9; SUMO 1 protein, 182213-10-1; ubiquitin, 60267-61-0; cell adhesion molecule F11; Cytokines; DNA-Binding Proteins; Neural Cell Adhesion Molecules; Protein-Tyrosine Kinases, EC 2.7.1.112; STAT1 protein, human; STAT1 Transcription Factor; STAT3 protein, human; STAT3 Transcription Factor; Trans-Activators
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_15216543_v56_n2_p83_CarbiaNagashima.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15216543_v56_n2_p83_CarbiaNagashima

Referencias:

  • Arzt, E., Pereda, M.P., Castro, C.P., Pagotto, U., Renner, U., Stalla, G.K., Pathophysiological role of the cytokine network in the anterior pituitary gland (1999) Front. Neuroendocrinol., 20, pp. 71-95
  • Hirano, T., Interleukin-6 (1994) The Cytokine Handbook, pp. 145-168. , (Thomson, A. W., ed.). Academic Press, Osaka
  • Kishimoto, T., Taga, T., Akira, S., Cytokine signal transduction (1994) Cell, 76, pp. 253-262
  • Kishimoto, T., Akira, S., Mazaki, M., Taga, T., Interleukin-6 family of cytokines and gp130 (1995) Blood, 86, pp. 1243-1253
  • Ray, D., Melmed, S., Pituitary cytokine and growth factor expression and action (1997) Endocrine Rev., 18, pp. 206-228
  • Heinrich, P.C., Behrmann, I., Muller-Newen, G., Schaper, F., Graeve, L., Interleukin-6-type cytokine signalling throgh the gp130/Jak/STAT pathway (1998) Biochem. J., 334, pp. 297-314
  • Barton, V.A., Hall, M.A., Hudson, K.R., Heath, J.K., Interleukin-11 signals through the formation of a hexameric receptor complex (2000) J. Biol. Chem., 275, pp. 36197-36203
  • Levy, D.E., Darnell Jr., J.E., Stats: Transcriptional control and biological impact (2002) Nat. Rev. Mol. Cell. Biol., 3, pp. 651-662
  • Hirano, T., Ishihara, K., Hibi, M., Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors (2000) Oncogene, 19, pp. 2548-2556
  • Yoshida, K., Taga, T., Saito, M., Suematsu, S., Kumanogoh, A., Tanaka, T., Fujiwara, H., Nakahata, T., Targeted disruption of gp 130, a common signal transducer for the interleukin-6 family, leads to myocardial and hematological disorders (1996) Proc. Natl. Acad. Sci., 93, pp. 407-411
  • Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., Akira, S., Targeted disruption of the mouse Stat3 gene leads to early embryonic lathality (1997) Proc. Natl. Acad. Sci., 94, pp. 3801-3804
  • Rodig, S.J., Meraz, M.A., White, J.M., Lampe, P.A., Riley, J.K., Arthur, C.D., Kind, K.L., Pennica, D., Disruption of the JaK1 gene demostrates obligatory and nonredundant roles of the JaKs in cytokine-induced biologic responses (1998) Cell, 93, pp. 373-383
  • Hirota, H., Yoshida, K., Kishimoto, T., Taga, T., Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice (1995) Proc. Natl. Acad. Sci. USA, 92, pp. 4862-4866
  • Betz, U.A., Bloch, W., Van Den Broek, M., Yoshida, K., Taga, T., Kishimoto, T., Addicks, K., Muller, W., Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects (1998) J. Exp. Med., 188, pp. 1955-1965
  • Nandurkar, H.H., Robb, L., Tarlinton, D., Barnett, L., Kontgen, F., Begley, C.G., Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis (1997) Blood, 90, pp. 2148-2159
  • Robb, L., Li, R., Hartley, L., Nandurkar, H.H., Koentgen, F., Begley, C.G., Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation (1998) Nat. Med., 4, pp. 303-308
  • Bernad, A., Kopf, M., Kulbacki, R., Weich, N., Koehler, G., Gutierrez-Ramos, J.C., Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system (1994) Immunity, 1, pp. 725-731
  • Poli, V., Balena, R., Fattori, E., Markatos, A., Yamamoto, M., Tanaka, H., Ciliberto, G., Costantini, F., Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion (1994) EMBO J., 13, pp. 1189-1196
  • Cressman, D.E., Greenbaum, L.E., DeAngelis, R.A., Ciliberto, G., Furth, E.E., Poli, V., Taub, R., Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice (1996) Science, 274, pp. 1379-1383
  • Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Kohler, G., Impaired immune and acute-phase responses in interleukin-6-deficient mice (1994) Nature, 368, pp. 339-342
  • Fattori, E., Cappelletti, M., Costa, P., Sellitto, C., Cantoni, L., Carelli, M., Faggioni, R., Poli, V., Defective inflammatory response in interleukin 6-deficient mice (1994) J. Exp. Med., 180, pp. 1243-1250
  • Escary, J.L., Perreau, J., Dumenil, D., Ezine, S., Brulet, P., Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation (1993) Nature, 363, pp. 361-364
  • Stewart, C.L., Kaspar, P., Brunet, L.J., Bhatt, H., Gadi, I., Kontgen, F., Abbondanzo, S.J., Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor (1992) Nature, 359, pp. 76-79
  • Masu, Y., Wolf, E., Holtmann, B., Sendtner, M., Brem, G., Thoenen, H., Disruption of the CNTF gene results in motor neuron degeneration (1993) Nature, 365, pp. 27-32
  • Uchiyama, H., Barut, B.A., Mohrbacher, A.F., Chauhan, D., Anderson, K.C., Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion (1993) Blood, 82, pp. 3712-3720
  • Kallen, K.J., The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases (2002) Biochim. Biophys. Acta, 1592, pp. 323-343
  • Arzt, E., Buric, R., Stelzer, G., Stalla, J., Sauer, J., Renner, U., Stalla, G.K., Interleukin involvement in anterior pituitary cell growth regulation: Effects of interleukin-2 (IL-2) and IL-6 (1993) Endocrinology, 132, pp. 459-467
  • Arzt, E., gp130 cytokine signaling in the pituitary gland: A paradigm for cytokine-neuro-endocrine pathways (2001) J. Clin. Invest., 108, pp. 1729-1733
  • Perez Castro, C., Nagashima, A.C., Pereda, M.P., Goldberg, V., Chervin, A., Largen, P., Renner, U., Arzt, E., The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines (2000) Endocrinology, 141, pp. 1746-1753
  • Castro, C.P., Giacomini, D., Nagashima, A.C., Onofri, C., Graciarena, M., Kobayashi, K., Paez-Pereda, M., Arzt, E., Reduced expression of the cytokine transducer gp130 inhibits hormone secretion, cell growth, and tumor development of pituitary lactosomatotrophic GH3 cells (2003) Endocrinology, 144, pp. 693-700
  • Bowman, T., Garcia, R., Turkson, J., Jove, R., STATs in oncogenesis (2000) Oncogene, 19, pp. 2474-2488
  • Bromberg, J.F., Wrzeszczynska, M.H., Devgan, G., Zhao, Y., Pestell, R.G., Albanese, C., Darnell Jr., J.E., Stat3 as an oncogene (1999) Cell, 98, pp. 295-303
  • David, M., Chen, H.E., Goelz, S., Larner, A.C., Neel, B.G., Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1 (1995) Mol. Cell. Biol., 15, pp. 7050-7058
  • Jiao, H., Berrada, K., Yang, W., Tabrizi, M., Platanias, L.C., Yi, T., Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1 (1996) Mol. Cell. Biol., 16, pp. 6985-6992
  • Ohtani, T., Ishihara, K., Atsumi, T., Nishida, K., Kaneko, Y., Miyata, T., Itoh, S., Fukada, T., Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses (2000) Immunity, 12, pp. 95-105
  • Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fujitani, Y., Yamaguchi, T., Nakajima, K., Hirano, T., Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in anti-apoptosis (1996) Immunity, 5, pp. 449-460
  • Starr, R., Willson, T.A., Viney, E.M., Murray, L.J., Rayner, J.R., Jenkins, B.J., Gonda, T.J., Hilton, D.J., A family of cytokine-inducible inhibitors of signalling (1997) Nature, 387, pp. 917-921
  • Endo, T.A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Misawa, H., A new protein containing an SH2 domain that inhibits JAK kinases (1997) Nature, 387, pp. 921-924
  • Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., Nishimoto, N., Kishimoto, T., Structure and function of a new STAT-induced STAT inhibitor (1997) Nature, 387, pp. 924-929
  • Hilton, D.J., Richardson, R.T., Alexander, W.S., Viney, E.M., Willson, T.A., Sprigg, N.S., Starr, R., Nicola, N.A., Twenty proteins containing a C-terminal SOCS box form five structural classes (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 114-119
  • Nicholson, S.E., Willson, T.A., Farley, A., Starr, R., Zhang, J.G., Baca, M., Alexander, W.S., Nicola, N.A., Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction (1999) EMBO J., 18, pp. 375-385
  • Nicholson, S.E., De Souza, D., Fabri, L.J., Corbin, J., Willson, T.A., Zhang, J.G., Silva, A., Nash, A.D., Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130 (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 6493-6498
  • Krebs, D.L., Hilton, D.J., SOCS: Physiological suppressors of cytokine signaling (2000) J. Cell. Sci., 113 (PART 16), pp. 2813-2819
  • Kamizono, S., Hanada, T., Yasukawa, H., Minoguchi, S., Kato, R., Minoguchi, M., Hattori, K., Morita, S., The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2 (2001) J. Biol. Chem., 276, pp. 12530-12538
  • Haan, S., Ferguson, P., Sommer, U., Hiremath, M., McVicar, D.W., Heinrich, P.C., Johnston, J.A., Cacalano, N.A., Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation (2003) J. Biol. Chem., 278, pp. 31972-31979
  • Shuai, K., Modulation of STAT signaling by STAT-interacting proteins (2000) Oncogene, 19, pp. 2638-2644
  • Johnson, E.S., Gupta, A.A., An E3-like factor that promotes SUMO conjugation to the yeast septins (2001) Cell, 106, pp. 735-744
  • Rogers, R.S., Horvath, C.M., Matunis, M.J., SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation (2003) J. Biol. Chem., 278, pp. 30091-30097
  • Melchior, F., SUMO-nonclassical ubiquitin (2000) Annu. Rev. Cell. Dev. Biol., 16, pp. 591-626
  • Yoshikawa, H., Matsubara, K., Qian, G.S., Jackson, P., Groopman, J.D., Manning, J.E., Harris, C.C., Herman, J.G., SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity (2001) Nat. Genet., 28, pp. 29-35
  • Zhang, Q., Raghunath, P.N., Xue, L., Majewski, M., Carpentieri, D.F., Odum, N., Morris, S., Wasik, M.A., Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma (2002) J. Immunol., 168, pp. 466-474

Citas:

---------- APA ----------
Carbia-Nagashima, A. & Arzt, E. (2004) . Intracellular Proteins and Mechanisms Involved in the Control of gp130/JAK/STAT Cytokine Signaling. IUBMB Life, 56(2), 83-88.
http://dx.doi.org/10.1080/15216540410001668064
---------- CHICAGO ----------
Carbia-Nagashima, A., Arzt, E. "Intracellular Proteins and Mechanisms Involved in the Control of gp130/JAK/STAT Cytokine Signaling" . IUBMB Life 56, no. 2 (2004) : 83-88.
http://dx.doi.org/10.1080/15216540410001668064
---------- MLA ----------
Carbia-Nagashima, A., Arzt, E. "Intracellular Proteins and Mechanisms Involved in the Control of gp130/JAK/STAT Cytokine Signaling" . IUBMB Life, vol. 56, no. 2, 2004, pp. 83-88.
http://dx.doi.org/10.1080/15216540410001668064
---------- VANCOUVER ----------
Carbia-Nagashima, A., Arzt, E. Intracellular Proteins and Mechanisms Involved in the Control of gp130/JAK/STAT Cytokine Signaling. IUBMB Life. 2004;56(2):83-88.
http://dx.doi.org/10.1080/15216540410001668064