A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa. © 2012 Copyright Taylor and Francis Group, LLC.
| Documento: | Artículo |
| Título: | Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus |
| Autor: | Careaga, V.P.; Bueno, C.; Muniain, C.; Alché, L.; Maier, M.S. |
| Filiación: | UMYMFOR (CONICET - UBA), Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Pabellón 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Pabellón 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina Laboratorio de Ecología Química y Biodiversidad Acuática, Instituto de Investigación e Ingeniería Ambiental, Universidad Nacional de San Martín, Peatonal Belgrano 3563 1, 1650 San Martín, Buenos Aires, Argentina |
| Idioma: | Inglés |
| Palabras clave: | antiproliferative; cytotoxic; Pseudocnus dubiosus leoninus; sulphated triterpene glycosides |
| Año: | 2012 |
| DOI: | http://dx.doi.org/10.1080/14786419.2012.751596 |
| Título revista: | Natural Product Research |
| Título revista abreviado: | Nat. Prod. Res. |
| ISSN: | 14786419 |
| CODEN: | NPRAA |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14786419_v_n_p_Careaga |
