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Abstract:

Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells. © 2012 IOP Publishing Ltd.

Registro:

Documento: Artículo
Título:Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
Autor:Uriu, K.; Ares, S.; Oates, A.C.; Morelli, L.G.
Filiación:Theoretical Biology Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany
Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, 01187 Dresden, Germany
Grupo Interdisciplinar de Sistemas Complejos (GISC), Madrid, Spain
Departamento de Física, FCEyN, UBA, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Logic of Genomic Systems Laboratory, Centro Nacional de Biotecnología, CSIC, Calle Darwin 3, 28049 Madrid, Spain
Palabras clave:animal; article; biological model; biological rhythm; cell communication; cell motion; computer simulation; human; morphogenesis; signal transduction; Animals; Biological Clocks; Cell Communication; Cell Movement; Computer Simulation; Humans; Models, Biological; Morphogenesis; Signal Transduction
Año:2012
Volumen:9
Número:3
DOI: http://dx.doi.org/10.1088/1478-3975/9/3/036006
Título revista:Physical Biology
Título revista abreviado:Phys. Biol.
ISSN:14783967
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14783967_v9_n3_p_Uriu

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Citas:

---------- APA ----------
Uriu, K., Ares, S., Oates, A.C. & Morelli, L.G. (2012) . Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions. Physical Biology, 9(3).
http://dx.doi.org/10.1088/1478-3975/9/3/036006
---------- CHICAGO ----------
Uriu, K., Ares, S., Oates, A.C., Morelli, L.G. "Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions" . Physical Biology 9, no. 3 (2012).
http://dx.doi.org/10.1088/1478-3975/9/3/036006
---------- MLA ----------
Uriu, K., Ares, S., Oates, A.C., Morelli, L.G. "Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions" . Physical Biology, vol. 9, no. 3, 2012.
http://dx.doi.org/10.1088/1478-3975/9/3/036006
---------- VANCOUVER ----------
Uriu, K., Ares, S., Oates, A.C., Morelli, L.G. Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions. Phys. Biol. 2012;9(3).
http://dx.doi.org/10.1088/1478-3975/9/3/036006