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Caterino, M.; Petruk, A.A.; Vergara, A.; Ferraro, G.; Marasco, D.; Doctorovich, F.; Estrin, D.A.; Merlino, A. "Mapping the protein-binding sites for iridium(III)-based CO-releasing molecules" (2016) Dalton Transactions. 45(30):12206-12214
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Abstract:

A combination of mass spectrometry, Raman microspectroscopy, circular dichroism and X-ray crystallography has been used to obtain detailed information on the reaction of an iridium-based CO-releasing molecule (Ir-CORM), Cs2IrCl5CO, with a model protein, bovine pancreatic ribonuclease. The results show that Ir-compound fragments bind to the N-terminal amine and close to histidine and methionine side chains, and the CO ligand is retained for a long time. The data provide helpful information for identifying protein targets for Ir-CORMs and for studying the mechanism that allows them to exhibit their interesting biological properties. © The Royal Society of Chemistry 2016.

Registro:

Documento: Artículo
Título:Mapping the protein-binding sites for iridium(III)-based CO-releasing molecules
Autor:Caterino, M.; Petruk, A.A.; Vergara, A.; Ferraro, G.; Marasco, D.; Doctorovich, F.; Estrin, D.A.; Merlino, A.
Filiación:Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte sant'Angelo, Via Cintia, Napoli, I-80126, Italy
Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE-CONICET, University of Buenos Aires, Ciudad Universitaria, Pab. 2C1428EHA, Argentina
CNR Institute of Biostructures and Bioimages, Via Mezzocannone 16, Napoli, Italy
Department of Pharmacy, University of Naples Federico II, Italy
Palabras clave:Amino acids; Binding sites; Bins; Biochemistry; Crystallography; Dichroism; Iridium; Mass spectrometry; Molecules; Proteins; Biological properties; Bovine pancreatic ribonuclease; Model proteins; N-terminals; Protein targets; Protein-binding sites; Raman microspectroscopy; Side-chains; X ray crystallography; carbon monoxide; iridium; protein; protein binding; binding site; chemical structure; chemistry; circular dichroism; mass spectrometry; Raman spectrometry; X ray crystallography; Binding Sites; Carbon Monoxide; Circular Dichroism; Crystallography, X-Ray; Iridium; Mass Spectrometry; Molecular Structure; Protein Binding; Proteins; Spectrum Analysis, Raman
Año:2016
Volumen:45
Número:30
Página de inicio:12206
Página de fin:12214
DOI: http://dx.doi.org/10.1039/c6dt01685e
Título revista:Dalton Transactions
Título revista abreviado:Dalton Trans.
ISSN:14779226
CODEN:DTARA
CAS:carbon monoxide, 630-08-0; iridium, 13967-67-4, 7439-88-5; protein, 67254-75-5; Carbon Monoxide; Iridium; Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14779226_v45_n30_p12206_Caterino

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Citas:

---------- APA ----------
Caterino, M., Petruk, A.A., Vergara, A., Ferraro, G., Marasco, D., Doctorovich, F., Estrin, D.A.,..., Merlino, A. (2016) . Mapping the protein-binding sites for iridium(III)-based CO-releasing molecules. Dalton Transactions, 45(30), 12206-12214.
http://dx.doi.org/10.1039/c6dt01685e
---------- CHICAGO ----------
Caterino, M., Petruk, A.A., Vergara, A., Ferraro, G., Marasco, D., Doctorovich, F., et al. "Mapping the protein-binding sites for iridium(III)-based CO-releasing molecules" . Dalton Transactions 45, no. 30 (2016) : 12206-12214.
http://dx.doi.org/10.1039/c6dt01685e
---------- MLA ----------
Caterino, M., Petruk, A.A., Vergara, A., Ferraro, G., Marasco, D., Doctorovich, F., et al. "Mapping the protein-binding sites for iridium(III)-based CO-releasing molecules" . Dalton Transactions, vol. 45, no. 30, 2016, pp. 12206-12214.
http://dx.doi.org/10.1039/c6dt01685e
---------- VANCOUVER ----------
Caterino, M., Petruk, A.A., Vergara, A., Ferraro, G., Marasco, D., Doctorovich, F., et al. Mapping the protein-binding sites for iridium(III)-based CO-releasing molecules. Dalton Trans. 2016;45(30):12206-12214.
http://dx.doi.org/10.1039/c6dt01685e