Artículo
Steyn, F.J.; Ngo, S.T.; Chen, V.P.; Bailey-Downs, L.C.; Xie, T.Y.; Ghadami, M.; Brimijoin, S.; Freeman, W.M.; Rubinstein, M.; Low, M.J.; Stout, M.B. "17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior" (2018) Aging Cell. 17(1)
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Abstract:
Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
Registro:
| Documento: | Artículo |
| Título: | 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior |
| Autor: | Steyn, F.J.; Ngo, S.T.; Chen, V.P.; Bailey-Downs, L.C.; Xie, T.Y.; Ghadami, M.; Brimijoin, S.; Freeman, W.M.; Rubinstein, M.; Low, M.J.; Stout, M.B. |
| Filiación: | University of Queensland Centre for Clinical Research, Faculty of Medicine, Brisbane, QLD, Australia Department of Neurology, Royal Brisbane & Women's Hospital, Brisbane, QLD, Australia Wesley Medical Research, Auchenflower, QLD, Australia Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD, Australia Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United States Department of Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, United States |
| Palabras clave: | 17α-estradiol; aging; food intake; hypothalamus; obesity; pro-opiomelanocortin; 17alpha estradiol; glucose; insulin; proopiomelanocortin; animal experiment; appetite; arcuate nucleus; Article; body mass; caloric intake; controlled study; feeding behavior; food intake; gene; gene expression; genetic transcription; glucose blood level; homeostasis; hypothalamus; insulin blood level; male; metabolic balance; mouse; nonhuman; obesity; Pomc gene; priority journal; protein expression; satiety |
| Año: | 2018 |
| Volumen: | 17 |
| Número: | 1 |
| DOI: | http://dx.doi.org/10.1111/acel.12703 |
| Título revista: | Aging Cell |
| Título revista abreviado: | Aging Cell |
| ISSN: | 14749718 |
| CODEN: | ACGEC |
| CAS: | 17alpha estradiol, 57-91-0; glucose, 50-99-7, 84778-64-3; insulin, 9004-10-8; proopiomelanocortin, 66796-54-1 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14749718_v17_n1_p_Steyn |
Referencias:
- Benoit, S.C., Air, E.L., Coolen, L.M., Strauss, R., Jackman, A., Clegg, D.J., Woods, S.C., The catabolic action of insulin in the brain is mediated by melanocortins (2002) The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 22, pp. 9048-9052
- Bumaschny, V.F., Yamashita, M., Casas-Cordero, R., Otero-Corchon, V., de Souza, F.S., Rubinstein, M., Low, M.J., Obesity-programmed mice are rescued by early genetic intervention (2012) The Journal of Clinical Investigation, 122, pp. 4203-4212
- Butera, P.C., Beikirch, R.J., Willard, D.M., Changes in ingestive behaviors and body weight following intracranial application of 17 alpha-estradiol (1990) Physiology & Behavior, 47, pp. 1291-1293
- Chhabra, K.H., Adams, J.M., Fagel, B., Lam, D.D., Qi, N., Rubinstein, M., Low, M.J., Hypothalamic POMC deficiency improves glucose tolerance despite insulin resistance by increasing glycosuria (2016) Diabetes, 65, pp. 660-672
- Cowley, M.A., Smart, J.L., Rubinstein, M., Cerdan, M.G., Diano, S., Horvath, T.L., Low, M.J., Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus (2001) Nature, 411, pp. 480-484
- de Souza, F.S., Santangelo, A.M., Bumaschny, V., Avale, M.E., Smart, J.L., Low, M.J., Rubinstein, M., Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting (2005) Molecular and Cellular Biology, 25, pp. 3076-3086
- Dirks, A.J., Leeuwenburgh, C., Caloric restriction in humans: potential pitfalls and health concerns (2006) Mechanisms of Ageing and Development, 127, pp. 1-7
- Franchini, L.F., Lopez-Leal, R., Nasif, S., Beati, P., Gelman, D.M., Low, M.J., Rubinstein, M., Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons (2011) Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 15270-15275
- Harrison, D.E., Strong, R., Allison, D.B., Ames, B.N., Astle, C.M., Atamna, H., Miller, R.A., Acarbose, 17-alpha-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males (2014) Aging Cell, 13, pp. 273-282
- Lam, D.D., de Souza, F.S., Nasif, S., Yamashita, M., Lopez-Leal, R., Otero-Corchon, V., Low, M.J., Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold (2015) PLoS Genetics, 11
- Stout, M.B., Steyn, F.J., Jurczak, M.J., Camporez, J.G., Zhu, Y., Hawse, J.R., Kirkland, J.L., 17alpha-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization (2017) Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 72, pp. 3-15
- Strong, R., Miller, R.A., Antebi, A., Astle, C.M., Bogue, M., Denzel, M.S., Harrison, D.E., Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an alpha-glucosidase inhibitor or a Nrf2-inducer (2016) Aging Cell, 15, pp. 872-884
- Waters, D.L., Ward, A.L., Villareal, D.T., Weight loss in obese adults 65 years and older: a review of the controversy (2013) Experimental Gerontology, 48, pp. 1054-1061
- Zhan, C., Zhou, J., Feng, Q., Zhang, J.E., Lin, S., Bao, J., Luo, M., Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively (2013) The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 33, pp. 3624-3632
Citas:
---------- APA ----------
Steyn, F.J., Ngo, S.T., Chen, V.P., Bailey-Downs, L.C., Xie, T.Y., Ghadami, M., Brimijoin, S.,..., Stout, M.B. (2018) . 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. Aging Cell, 17(1).http://dx.doi.org/10.1111/acel.12703
---------- CHICAGO ----------
Steyn, F.J., Ngo, S.T., Chen, V.P., Bailey-Downs, L.C., Xie, T.Y., Ghadami, M., et al. "17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior" . Aging Cell 17, no. 1 (2018).http://dx.doi.org/10.1111/acel.12703
---------- MLA ----------
Steyn, F.J., Ngo, S.T., Chen, V.P., Bailey-Downs, L.C., Xie, T.Y., Ghadami, M., et al. "17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior" . Aging Cell, vol. 17, no. 1, 2018.http://dx.doi.org/10.1111/acel.12703
---------- VANCOUVER ----------
Steyn, F.J., Ngo, S.T., Chen, V.P., Bailey-Downs, L.C., Xie, T.Y., Ghadami, M., et al. 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. Aging Cell. 2018;17(1).http://dx.doi.org/10.1111/acel.12703
