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Abstract:

Factors such as charge, aggregation and lipophilicity influence photosensitiser localisation. The lipophilic octasubstituted sensitiser 2,3,9,10,16,17,23,24-octakis(decyloxy)phthalocyaninato zinc(II) was incorporated into liposomes of dimyristoyl-L-α-phosphatidylcholine (DMPC), non-ionic micelles of Tween 80 and the hydrosoluble polymer Solutol® HS 15 in order to investigate how these different environments affect the photophysical properties and phototoxicity of the photosensitiser. Fluorescence quantum yields and singlet molecular oxygen generation are enhanced in the presence of Solutol® HS 15. Phototoxicities were calculated by employing a concentration of 10-7 M of the dye against the Hcp-2 cell line, which showed a viability of 53 and 30% in DMPC and Solutol® HS 15, respectively. After 24 h of photodynamic therapy with 15 min irradiation, apoptotic and necrotic cells were observed. © The Royal Society of Chemistry and Owner Societies 2003.

Registro:

Documento: Artículo
Título:A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles
Autor:Rodriguez, M.E.; Morán, F.; Bonansea, A.; Monetti, M.; Fernández, D.A.; Strassert, C.A.; Rivarola, V.; Awruch, J.; Dicelio, L.E.
Filiación:Departamento de Quimica Inorgánica, Analitica y Quimica Fisica, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina
Departamento de Biologiá Molecular, Universidad Nacional de Rio Cuarto, Ruta 8 Km 601, 5800 Rio Cuarto, Córdoba, Argentina
Palabras clave:2,3,9,10,16,17,23,24 octakis(decyloxy)phthalocyaninato zinc; dimyristoylphosphatidylcholine; liposome; photosensitizing agent; polymer; polysorbate 80; singlet oxygen; solutol hs 15; unclassified drug; zinc derivative; dimyristoylphosphatidylcholine; liposome; organometallic compound; photosensitizing agent; polymer; apoptosis; article; cell death; cell viability; controlled study; drug mechanism; drug structure; HEp 2 cell; human; human cell; irradiation; lipophilicity; micelle; photodynamic therapy; phototoxicity; priority journal; biology; cell line; cell survival; chemistry; comparative study; drug effect; necrosis; photochemistry; photochemotherapy; Apoptosis; Cell Line; Cell Survival; Dimyristoylphosphatidylcholine; Humans; Liposomes; Micelles; Necrosis; Organometallic Compounds; Photobiology; Photochemistry; Photochemotherapy; Photosensitizing Agents; Polymers
Año:2003
Volumen:2
Número:10
Página de inicio:988
Página de fin:994
DOI: http://dx.doi.org/10.1039/b303428n
Título revista:Photochemical and Photobiological Sciences
Título revista abreviado:Photochem. Photobiol. Sci.
ISSN:1474905X
CODEN:PPSHC
CAS:dimyristoylphosphatidylcholine, 13699-48-4, 18194-24-6; polysorbate 80, 8050-83-7, 9005-65-6; Dimyristoylphosphatidylcholine, 13699-48-4; Liposomes; Micelles; Organometallic Compounds; Photosensitizing Agents; Polymers
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1474905X_v2_n10_p988_Rodriguez

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Citas:

---------- APA ----------
Rodriguez, M.E., Morán, F., Bonansea, A., Monetti, M., Fernández, D.A., Strassert, C.A., Rivarola, V.,..., Dicelio, L.E. (2003) . A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles. Photochemical and Photobiological Sciences, 2(10), 988-994.
http://dx.doi.org/10.1039/b303428n
---------- CHICAGO ----------
Rodriguez, M.E., Morán, F., Bonansea, A., Monetti, M., Fernández, D.A., Strassert, C.A., et al. "A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles" . Photochemical and Photobiological Sciences 2, no. 10 (2003) : 988-994.
http://dx.doi.org/10.1039/b303428n
---------- MLA ----------
Rodriguez, M.E., Morán, F., Bonansea, A., Monetti, M., Fernández, D.A., Strassert, C.A., et al. "A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles" . Photochemical and Photobiological Sciences, vol. 2, no. 10, 2003, pp. 988-994.
http://dx.doi.org/10.1039/b303428n
---------- VANCOUVER ----------
Rodriguez, M.E., Morán, F., Bonansea, A., Monetti, M., Fernández, D.A., Strassert, C.A., et al. A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles. Photochem. Photobiol. Sci. 2003;2(10):988-994.
http://dx.doi.org/10.1039/b303428n