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Abstract:

We have devised a new caged GABA based on ruthenium bipyridyl coordination chemistry. This phototrigger delivers GABA upon irradiation with wavelengths up to 532 nm undergoing heterolytic photocleavage, in a clean and very fast (a few nanoseconds) photoreaction. With an absorptivity coefficient εMAX = 5300 M-1 cm-1 at 447 nm and a quantum efficiency φ ∼ 0.09, RuBiGABA-2 is among the most active caged-GABAs, especially at long wavelengths. This highly hydrophilic caged GABA can be synthesized in a simple one-pot reaction. The synthesis, chemical characterization and photochemical properties are presented. Finally, the usefulness of this caged compound is demonstrated by photodelivering free GABA on leech motoneurons. © 2013 The Royal Society of Chemistry and Owner Societies.

Registro:

Documento: Artículo
Título:RuBiGABA-2: A hydrophilic caged GABA with long wavelength sensitivity
Autor:Filevich, O.; Etchenique, R.
Filiación:Departamento de Química Inorgánica, Analítica y Química Física, Universidad de Buenos Aires, Pabellón 2, (C1428EHA) Buenos Aires, Argentina
Palabras clave:2,2' bipyridine; 4 aminobutyric acid; bis(bipyridyl)ruthenium(II); drug derivative; GABAergic receptor affecting agent; organometallic compound; phosphine derivative; 2,2' bipyridine; 4 aminobutyric acid; GABAergic receptor affecting agent; organometallic compound; phosphine derivative; animal; article; chemical phenomena; chemistry; cytology; drug effect; ganglion; leech; light; photolysis; analogs and derivatives; drug effects; 2,2'-Dipyridyl; Animals; GABA Agents; gamma-Aminobutyric Acid; Ganglia; Hydrophobic and Hydrophilic Interactions; Leeches; Light; Organometallic Compounds; Phosphines; Photolysis; 2,2'-Dipyridyl; Animals; GABA Agents; gamma-Aminobutyric Acid; Ganglia; Hydrophobic and Hydrophilic Interactions; Leeches; Light; Organometallic Compounds; Phosphines; Photolysis
Año:2013
Volumen:12
Número:9
Página de inicio:1565
Página de fin:1570
DOI: http://dx.doi.org/10.1039/c3pp25248e
Título revista:Photochemical and Photobiological Sciences
Título revista abreviado:Photochem. Photobiol. Sci.
ISSN:1474905X
CODEN:PPSHC
CAS:2,2' bipyridine, 366-18-7; 4 aminobutyric acid, 28805-76-7, 56-12-2; 2,2'-Dipyridyl, 551W113ZEP; GABA Agents; Organometallic Compounds; Phosphines; bis(bipyridyl)ruthenium(II); gamma-Aminobutyric Acid, 56-12-2; 2,2'-Dipyridyl; bis(bipyridyl)ruthenium(II); GABA Agents; gamma-Aminobutyric Acid; Organometallic Compounds; Phosphines
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1474905X_v12_n9_p1565_Filevich

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Citas:

---------- APA ----------
Filevich, O. & Etchenique, R. (2013) . RuBiGABA-2: A hydrophilic caged GABA with long wavelength sensitivity. Photochemical and Photobiological Sciences, 12(9), 1565-1570.
http://dx.doi.org/10.1039/c3pp25248e
---------- CHICAGO ----------
Filevich, O., Etchenique, R. "RuBiGABA-2: A hydrophilic caged GABA with long wavelength sensitivity" . Photochemical and Photobiological Sciences 12, no. 9 (2013) : 1565-1570.
http://dx.doi.org/10.1039/c3pp25248e
---------- MLA ----------
Filevich, O., Etchenique, R. "RuBiGABA-2: A hydrophilic caged GABA with long wavelength sensitivity" . Photochemical and Photobiological Sciences, vol. 12, no. 9, 2013, pp. 1565-1570.
http://dx.doi.org/10.1039/c3pp25248e
---------- VANCOUVER ----------
Filevich, O., Etchenique, R. RuBiGABA-2: A hydrophilic caged GABA with long wavelength sensitivity. Photochem. Photobiol. Sci. 2013;12(9):1565-1570.
http://dx.doi.org/10.1039/c3pp25248e