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Abstract:

The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding proteins or lectins. Galectins, a family of animal lectins that bind N-acetyllactosamine- containing glycans, have many roles in diverse immune cell processes, including those relevant to pathogen recognition, shaping the course of adaptive immune responses and fine-tuning the inflammatory response. How do galectins translate glycan-encoded information into tolerogenic or inflammatory cell programmes? An improved understanding of the mechanisms underlying these functions will provide further opportunities for developing new therapies based on the immunoregulatory properties of this multifaceted protein family. © 2009 Macmillan Publishers Limited.

Registro:

Documento: Artículo
Título:Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation
Autor:Rabinovich, G.A.; Toscano, M.A.
Filiación:Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Ciudad de Buenos Aires, Argentina
Departamento de Química Biológica, Facultad DeCiencias Exactas y Naturales, Ciudad de Buenos Aires, Argentina
Palabras clave:ecalectin; galectin; galectin 1; galectin 10; galectin 11; galectin 12; galectin 13; galectin 15; galectin 2; galectin 3; galectin 5; galectin 6; galectin 7; galectin 8; glycan; glycoprotein; interleukin 6; lectin; toll like receptor; unclassified drug; adaptive immunity; allergy; autoimmune disease; autoimmunity; cell survival; chronic inflammation; cytokine release; dendritic cell; homeostasis; host pathogen interaction; human; immune response; immunity; immunocompetent cell; immunological tolerance; immunoregulation; lymphocyte function; nonhuman; priority journal; protein interaction; protein structure; regulatory T lymphocyte; review; T lymphocyte; T lymphocyte activation; Animals; Disease; Galectins; Homeostasis; Humans; Immune Tolerance; Inflammation; Polysaccharides
Año:2009
Volumen:9
Número:5
Página de inicio:338
Página de fin:352
DOI: http://dx.doi.org/10.1038/nri2536
Título revista:Nature Reviews Immunology
Título revista abreviado:Nat. Rev. Immunol.
ISSN:14741733
CODEN:NRIAB
CAS:galectin 1, 258495-34-0; galectin 3, 208128-56-7; galectin 8, 220452-97-1; toll like receptor, 409141-78-2; Galectins; Polysaccharides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14741733_v9_n5_p338_Rabinovich

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Citas:

---------- APA ----------
Rabinovich, G.A. & Toscano, M.A. (2009) . Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation. Nature Reviews Immunology, 9(5), 338-352.
http://dx.doi.org/10.1038/nri2536
---------- CHICAGO ----------
Rabinovich, G.A., Toscano, M.A. "Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation" . Nature Reviews Immunology 9, no. 5 (2009) : 338-352.
http://dx.doi.org/10.1038/nri2536
---------- MLA ----------
Rabinovich, G.A., Toscano, M.A. "Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation" . Nature Reviews Immunology, vol. 9, no. 5, 2009, pp. 338-352.
http://dx.doi.org/10.1038/nri2536
---------- VANCOUVER ----------
Rabinovich, G.A., Toscano, M.A. Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation. Nat. Rev. Immunol. 2009;9(5):338-352.
http://dx.doi.org/10.1038/nri2536