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Abstract:

Herein we describe the characteristic features of the Anp32 family represented by the cerebellar leucine-rich repeat protein (Lanp) and the cerebellar developmental-regulated protein 1 (Cpd1). The Anp32 family consists of 32 evolutionarily-conserved proteins and is included within the superfamily of leucine-rich repeat (LRR) proteins characterized by the presence of tandem arrays of a LRR, a structural motif implicated in the mediation of protein-protein interactions. We describe three novel human Anp32 proteins, reveal the evolutionary relationships of the members of the Anp32 family, provide insights into their biochemical and structural properties, and review their macromolecular interactions, substrate specificities, tissue distribution/expression patterns, and physiological and pathological roles. Recent findings indicate a conserved role of members of the Anp32 family during evolution in the modulation of cell signalling and transduction of gene expression to regulate the morphology and dynamics of the cytoskeleton, cell adhesion, neural development or cerebellar morphogenesis. © 2005 Taylor & Francis Group Ltd.

Registro:

Documento: Artículo
Título:The Anp32 family of proteins containing leucine-rich repeats
Autor:Matilla, A.; Radrizzani, M.
Filiación:Institute of Child Health, University College London, London, United Kingdom
Fundación Instituto Leloir, IIB-FCEyN-UBA, Buenos Aires, Argentina
Ctro. Nac. de Genet. Medica (ANLIS), Buenos Aires, Argentina
Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
Palabras clave:Anp32; Cpd1; Lanp; Leucine-rich repeats; Signal transduction; adenine; cytosine; leucine; nuclear protein; protein anp32; protein cpd1; protein lanp; regulator protein; unclassified drug; amino acid sequence; cell adhesion; cell structure; cerebellum; cytoskeleton; evolution; gene expression; human; morphogenesis; nervous system development; nucleotide sequence; priority journal; protein expression; protein function; protein localization; protein motif; protein protein interaction; review; sequence analysis; signal transduction; structure analysis; tandem repeat; tissue distribution; Amino Acid Sequence; Animals; Cerebellum; Humans; Molecular Sequence Data; Nerve Tissue Proteins; Neurodegenerative Diseases; Nuclear Proteins; Phylogeny; Protein Structure, Tertiary; Proteins; Sequence Alignment; Sequence Homology, Amino Acid
Año:2005
Volumen:4
Número:1
Página de inicio:7
Página de fin:18
DOI: http://dx.doi.org/10.1080/14734220410019020
Título revista:Cerebellum
Título revista abreviado:Cerebellum
ISSN:14734222
CODEN:CEREC
CAS:adenine, 22177-51-1, 2922-28-3, 73-24-5; cytosine, 71-30-7; leucine, 61-90-5, 7005-03-0; Anp32e protein, mouse; leucine-rich repeat proteins; Nerve Tissue Proteins; Nuclear Proteins; Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14734222_v4_n1_p7_Matilla

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Citas:

---------- APA ----------
Matilla, A. & Radrizzani, M. (2005) . The Anp32 family of proteins containing leucine-rich repeats. Cerebellum, 4(1), 7-18.
http://dx.doi.org/10.1080/14734220410019020
---------- CHICAGO ----------
Matilla, A., Radrizzani, M. "The Anp32 family of proteins containing leucine-rich repeats" . Cerebellum 4, no. 1 (2005) : 7-18.
http://dx.doi.org/10.1080/14734220410019020
---------- MLA ----------
Matilla, A., Radrizzani, M. "The Anp32 family of proteins containing leucine-rich repeats" . Cerebellum, vol. 4, no. 1, 2005, pp. 7-18.
http://dx.doi.org/10.1080/14734220410019020
---------- VANCOUVER ----------
Matilla, A., Radrizzani, M. The Anp32 family of proteins containing leucine-rich repeats. Cerebellum. 2005;4(1):7-18.
http://dx.doi.org/10.1080/14734220410019020