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Abstract:

Obesity constitutes a health problem of increasing worldwide prevalence. Among the health detriments caused by obesity, reproduction is disrupted. However, the mechanisms involved in this disruption are not fully understood. Animals fed a cafeteria diet constitute the model for the study of obesity that most closely reflects Western diet habits. The aims of this study were to evaluate whether a cafeteria diet affects ovarian function and to contribute to the understanding of the mechanisms involved. For that purpose, 22-day-old female Wistar rats were fed ad libitum with a standard diet (control group; n = 20) or cafeteria diet (CAF group; n = 20). The cafeteria diet induced obesity and hyperglycaemia, without altering serum triglycerides, cholesterol or C-reactive protein concentrations. This diet also altered ovarian function: the rats showed prolonged dioestrous phases, decreased serum oestradiol concentrations and increased number of antral atretic follicles. Moreover, follicular cysts were detected in the CAF group, concomitantly with a decrease in the number of anti-Müllerian hormone immunoreactive pre-antral follicles and COX-2-positive antral and pre-ovulatory follicles. The authors conclude that a cafeteria diet reduces ovarian reserve, induces the presence of follicular cysts and disturbs the ovulatory process, leading to the delayed pregnancy observed in these animals. © 2015 Reproductive Healthcare Ltd.

Registro:

Documento: Artículo
Título:Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets
Autor:Bazzano, M.V.; Torelli, C.; Pustovrh, M.C.; Paz, D.A.; Elia, E.M.
Filiación:Laboratorio de Biología Del Desarrollo, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET-UBA), Cdad. Universitaria, Pabellón 2, Buenos Aires, Argentina
Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Buenos Aires, Argentina
Departamento de Morfología, Escuela de Ciencias Básicas, Universidad Del Valle, Cali, Colombia
Palabras clave:anti-Müllerian hormone; fertility; follicular cyst; folliculogenesis; C reactive protein; cholesterol; cyclooxygenase 2; estradiol; Muellerian inhibiting factor; triacylglycerol; cholesterol; cyclooxygenase 2; Muellerian inhibiting factor; triacylglycerol; animal experiment; Article; cafeteria diet; cholesterol blood level; controlled study; diet; diet induced obesity; estradiol blood level; estrus cycle; female; female fertility; follicle cyst; hyperglycemia; immunoreactivity; nonhuman; obesity; ovarian reserve; ovary function; pregnancy; rat; triacylglycerol blood level; adverse effects; animal; blood; complication; Infertility, Female; metabolism; obesity; ovary; Western diet; Wistar rat; Animals; Anti-Mullerian Hormone; Cholesterol; Cyclooxygenase 2; Diet, Western; Female; Hyperglycemia; Infertility, Female; Obesity; Ovary; Pregnancy; Rats; Rats, Wistar; Triglycerides
Año:2015
Volumen:31
Número:5
Página de inicio:655
Página de fin:667
DOI: http://dx.doi.org/10.1016/j.rbmo.2015.08.004
Título revista:Reproductive BioMedicine Online
Título revista abreviado:Reprod. BioMed. Online
ISSN:14726483
CODEN:RBOEA
CAS:C reactive protein, 9007-41-4; cholesterol, 57-88-5; estradiol, 50-28-2; Muellerian inhibiting factor, 80497-65-0; Anti-Mullerian Hormone; Cholesterol; Cyclooxygenase 2; Triglycerides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14726483_v31_n5_p655_Bazzano

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Citas:

---------- APA ----------
Bazzano, M.V., Torelli, C., Pustovrh, M.C., Paz, D.A. & Elia, E.M. (2015) . Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets. Reproductive BioMedicine Online, 31(5), 655-667.
http://dx.doi.org/10.1016/j.rbmo.2015.08.004
---------- CHICAGO ----------
Bazzano, M.V., Torelli, C., Pustovrh, M.C., Paz, D.A., Elia, E.M. "Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets" . Reproductive BioMedicine Online 31, no. 5 (2015) : 655-667.
http://dx.doi.org/10.1016/j.rbmo.2015.08.004
---------- MLA ----------
Bazzano, M.V., Torelli, C., Pustovrh, M.C., Paz, D.A., Elia, E.M. "Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets" . Reproductive BioMedicine Online, vol. 31, no. 5, 2015, pp. 655-667.
http://dx.doi.org/10.1016/j.rbmo.2015.08.004
---------- VANCOUVER ----------
Bazzano, M.V., Torelli, C., Pustovrh, M.C., Paz, D.A., Elia, E.M. Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets. Reprod. BioMed. Online. 2015;31(5):655-667.
http://dx.doi.org/10.1016/j.rbmo.2015.08.004